Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Luwei Tao"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Several breast cancers may originate from mammary luminal cells and inactivating mutations of p53 are present in most triple-negative breast cancers. Here, the authors show that loss of p53 from luminal cells in mice results in their clonal expansion
Externí odkaz:
https://doaj.org/article/1f5356261f8642e39f9eb48de118f875
Publikováno v:
Stem Cell Reports, Vol 5, Iss 1, Pp 60-74 (2015)
It has been shown that the mammary luminal lineage could be maintained by luminal stem cells or long-lived progenitors, but their identity and role in breast cancer remain largely elusive. By lineage analysis using Wap-Cre mice, we found that, in nul
Externí odkaz:
https://doaj.org/article/fc4e337a806d4764b34e270338ffabb2
Publikováno v:
Stem Cell Reports, Vol 2, Iss 6, Pp 770-779 (2014)
Lineage tracing using Cre/lox transgenic mice provides a powerful tool for studying normal mammary epithelial cell (MEC) development and the cellular origins of mammary tumors under physiological settings. However, generation of new transgenic mice f
Externí odkaz:
https://doaj.org/article/a80b47c993f64a67845b7a8ed369b738
Prognostic Value of KRAS Mutation Subtypes and PD-L1 Expression in Patients With Lung Adenocarcinoma
Autor:
Ruoyu Miao, Akriti G Jain, Chung-Che Chang, Luwei Tao, Amanda Allen, Mark A. Socinski, Tarek Mekhail, Cheng Fang, Jian Guan, Yuan Du, Lingbin Meng, Brenda L. Rzeszutko, Jingxin Sun
Publikováno v:
Clinical Lung Cancer. 22:e506-e511
Background The prognostic value of different KRAS (Kirsten rat sarcoma viral oncogene) mutation subtypes and their association with programmed death ligand 1 (PD-L1) expression in lung adenocarcinoma (LADC) remain unclear. We examined the association
Autor:
Yue Jin, Ying Xie, Zhe Li, Xin Hu, Youzhong Wan, Dongxi Xiang, Luwei Tao, Luca Pinello, Yu Zhang, Guo-Cheng Yuan
Publikováno v:
Oncogene
LSD1 (KDM1A) is a histone demethylase that plays both oncogenic and tumor suppressor roles in breast cancer. However, the exact contexts under which it plays these opposite functions remain largely elusive. By characterizing its role in luminal breas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Most breast cancers may have a luminal origin. TP53 is one of the most frequently mutated genes in breast cancers. However, how p53 deficiency contributes to breast tumorigenesis from luminal cells remains elusive. Here we report that induced p53 los
Autor:
Ning Dai, Dongxi Xiang, Vladimir V. Botchkarev, Kelvin Xi Zhang, Anushka Dongre, Qing Chen, Norman Sachs, Ben Liu, Helena J. Randle, Hans Clevers, Zhe Li, Allison P. Clark, Ying Xie, David M. Livingston, Luwei Tao, Hua Wang, Aina He
Publikováno v:
Cell, 178(1), 135-151.e19. Elsevier B.V.
Cell
Cell
Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs), BRCA1 interacts with multiple proteins, including NUMB and HES1, to form complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035fabaee94f6b0cd59cd83bc0e451d0
https://pure.knaw.nl/portal/en/publications/0c13fdbc-f487-49e0-b405-e868b174f1e3
https://pure.knaw.nl/portal/en/publications/0c13fdbc-f487-49e0-b405-e868b174f1e3
Publikováno v:
J Vis Exp
Breast cancer is a heterogeneous disease, possibly due to complex interactions between different cells of origins and oncogenic events. Mouse models are instrumental in gaining insights into these complex processes. Although many mouse models have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acfa53ab4247380a6fb13c9f24c63fa
https://europepmc.org/articles/PMC6711171/
https://europepmc.org/articles/PMC6711171/
Autor:
Jian Guan, Xiang Zhu, Renching Wang, Mohammed Wazir, Salama Mohamed, Shahram Mori, Syed Askari Hasan, Akriti G Jain, Chung-Che Chang, Luwei Tao, Sherrie L. Perkins
Publikováno v:
Cureus
Background The inhibition of programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) signaling pathway has been shown to be an effective targeted therapy in fighting both solid organ cancers and hematological malignancies. PD-L1 expres
Publikováno v:
Cureus
Fibrous dysplasia (FD) is a benign bone disorder, in which normal bone structure is replaced by fibrous connective tissue. Polyostotic FD is also related to McCune-Albright syndrome with possible endocrine disorder and Cafe-au-lait macules. Although