An Interpretable Classification Model Using Gluten-Specific TCR Sequences Shows Diagnostic Potential in Coeliac Disease.

Autor: Fowler A; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool L69 3GF, UK., FitzPatrick M; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Shanmugarasa A; School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK., Ibrahim ASF; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Kockelbergh H; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool L69 3GF, UK., Yang HC; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Williams-Walker A; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Luu Hoang KN; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Evans S; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Provine N; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Klenerman P; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK., Soilleux EJ; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

Publikováno v: Biomolecules [Biomolecules] 2023 Nov 25; Vol. 13 (12). Date of Electronic Publication: 2023 Nov 25.

TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer.

Autor: Beatson RE; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Parente-Pereira AC; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Halim L; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Cozzetto D; Translational Bioinformatics, NIHR Biomedical Research Centre, Guy's and St. Thomas's NHS Foundation Trust and King's College London, London SE1 9RT, UK., Hull C; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Whilding LM; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Martinez O; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Taylor CA; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Obajdin J; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Luu Hoang KN; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Draper B; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Iqbal A; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK.; Cancer Bioinformatics, King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Hardiman T; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK.; Cancer Bioinformatics, King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Zabinski T; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Man F; King's College London, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London SE1 7EH, UK., de Rosales RTM; King's College London, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, London SE1 7EH, UK., Xie J; Bayer Healthcare Innovation Center, Mission Bay, 455 Mission Bay Boulevard South, San Francisco, CA 94158, USA., Aswad F; Bayer Healthcare Innovation Center, Mission Bay, 455 Mission Bay Boulevard South, San Francisco, CA 94158, USA., Achkova D; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Joseph CR; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Ciprut S; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Adami A; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Roider HG; Bayer AG, Müllerstrasse 178, 13342 Berlin, Germany., Hess-Stumpp H; Bayer AG, Müllerstrasse 178, 13342 Berlin, Germany., Győrffy B; Department of Bioinformatics, Semmelweis University, Budapest H1085, Hungary.; Cancer Biomarker Research Group, Research Center for Natural Science, Budapest H1117, Hungary., Quist J; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK.; Cancer Bioinformatics, King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Grigoriadis A; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK.; Cancer Bioinformatics, King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Sommer A; Bayer AG, Müllerstrasse 178, 13342 Berlin, Germany., Tutt ANJ; King's College London, Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Davies DM; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK., Maher J; King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London SE1 9RT, UK.; Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD, UK.; Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.; Leucid Bio, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2021 Dec 21; Vol. 2 (12), pp. 100473. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2021).