Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A.

Autor: Diego VP; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Luu BW; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas.; Haplogenics Corporation, Brownsville, Texas., Hofmann M; CSL Behring GmbH, Research, Marburg, Germany., Dinh LV; Haplogenics Corporation, Brownsville, Texas., Almeida M; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Powell JS; CSL Behring, Med Affairs, King of Prussia, Pennsylvania., Rajalingam R; Immunogenetics and Transplantation Laboratory, Department of Surgery, School of Medicine, University of California at San Francisco, California., Peralta JM; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Kumar S; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Sauna ZE; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapeutics, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland., Kellerman R; Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, North Carolina., Park Y; Department of Laboratory Medicine and Pathology, University of North Carolina at Chapel Hill, North Carolina., Key NS; Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, North Carolina.; Department of Laboratory Medicine and Pathology, University of North Carolina at Chapel Hill, North Carolina., Escobar MA; Division of Hematology, Department of Medicine, McGovern School of Medicine, University of Texas Health Sciences Center at Houston, Texas., Huynh H; CSL Limited Research, Bio21 Institute, Melbourne, Australia., Verhagen AM; CSL Limited Research, Bio21 Institute, Melbourne, Australia., Williams-Blangero S; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Lehmann PV; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio.; Cellular Technology Ltd, Shaker Heights, Ohio., Maraskovsky E; CSL Limited Research, Bio21 Institute, Melbourne, Australia., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas., Howard TE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas.; Haplogenics Corporation, Brownsville, Texas.; Department of Pathology and Lab Medicine, VA Valley Coastal Bend Healthcare Center, Harlingen, Texas.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Jan; Vol. 18 (1), pp. 201-216.

CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia.

Autor: Alayoubi, Abdulfatah M., Khawaji, Zakaria Y., Mohammed, Mohammed A., Mercier, François E.

Publikováno v: Annals of Hematology; Jun2024, Vol. 103 Issue 6, p1805-1817, 13p

The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes.

Autor: Porcheddu, Valeria, Lhomme, Gautier, Giraudet, Re´mi, Correia, Evelyne, Maillère, Bernard

Publikováno v: Frontiers in Immunology; 2024, p1-12, 12p

Single Nucleotide Polymorphisms : Human Variation and a Coming Revolution in Biology and Medicine

Autor: Zuben E. Sauna, Chava Kimchi-Sarfaty

This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has explod