Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lutz Wiesner"'
Autor:
Sarah Campion, Amy Inselman, Belinda Hayes, Costanza Casiraghi, David Joseph, Fabrizio Facchinetti, Fabrizio Salomone, Georg Schmitt, Julia Hui, Karen Davis-Bruno, Karen Van Malderen, LaRonda Morford, Luc De Schaepdrijver, Lutz Wiesner, Stephanie Kourula, Suna Seo, Susan Laffan, Vijay Urmaliya, Connie Chen
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity,
Externí odkaz:
https://doaj.org/article/2b780bb945cf480c8f579328eb912ef4
Evaluation of Juvenile Animal Studies for Pediatric CNS-Targeted Compounds: A Regulatory Perspective
Autor:
Jan Willem van der Laan, Nico C B de Jager, Cláudio Gouveia Roque, Isabel Vieira, Jacqueline Carleer, Karen van Malderen, Dinah Duarte, Fabien Lavergne, Lutz Wiesner, Gunter F. Egger
Publikováno v:
International Journal of Toxicology. SAGE Publications Inc.
Central nervous system (CNS)-targeted products are an important category of pediatric pharmaceuticals. In view of the significant postnatal maturation of the CNS, juvenile animal studies (JAS) are performed to support pediatric development of these n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772751dcdf430b1d2b9540c59ad95ea5
https://pubmed.ncbi.nlm.nih.gov/31662008
https://pubmed.ncbi.nlm.nih.gov/31662008
Publikováno v:
Pedobiologia. 47:646-650
Summary Strong pathogenic effects, including immunotoxicity and carcinogenesis of xenobiotics like TCDD and PCBs, in mammals are mainly mediated by the aryl hydrocarbon receptor (AHR). AHR-homologs have recently been shown for Caenorhabditis elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c24fa77838eb927f850a644254cff65
https://doi.org/10.1016/s0031-4056(04)70249-8
https://doi.org/10.1016/s0031-4056(04)70249-8
Publikováno v:
Hydrobiologia. 443:137-145
The present investigation was performed on zebra mussels, Dreissena polymorpha (Pallas), which were sampled from the Kleines Haff. As a part of the Oder estuary, the Kleines Haff acts as a sink for the load of the river Oder. Mussel shells and mussel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5192f83dc9d25c7ec1c660e43085c524
https://doi.org/10.1023/a:1017508523148
https://doi.org/10.1023/a:1017508523148
Publikováno v:
Pedobiologia. Oct/Dec2003, Vol. 47 Issue 5/6, p646-650. 5p.