Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Lutz Tautz"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Protein phosphorylation is an integral part of many cellular processes, not only in eukaryotes but also in bacteria. The discovery of both prokaryotic protein kinases and phosphatases has created interest in generating antibacterial therapeu
Externí odkaz:
https://doaj.org/article/5a91c53812b74b23ac61e202d9003bca
Publikováno v:
Bio-Protocol, Vol 12, Iss 18 (2022)
Disturbance of the dynamic balance between protein tyrosine phosphorylation and dephosphorylation, modulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), is known to be crucial for the development of many human disease
Externí odkaz:
https://doaj.org/article/29a2d535c559425ba91407d3f30490be
Autor:
Lester J Lambert, Stefan Grotegut, Maria Celeridad, Palak Gosalia, Laurent JS De Backer, Andrey A Bobkov, Sumeet Salaniwal, Thomas DY Chung, Fu-Yue Zeng, Ian Pass, Paul J Lombroso, Nicholas DP Cosford, Lutz Tautz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4417 (2021)
Many human diseases are the result of abnormal expression or activation of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Not surprisingly, more than 30 tyrosine kinase inhibitors (TKIs) are currently in clinical use and pr
Externí odkaz:
https://doaj.org/article/5454ee00a74b4221be0bed42fc927bef
Autor:
Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J. Lambert, Maria Celeridad, Ming Zhao, Karina Barbosa, Laurent J.S. De Backer, Elizabeth Kwong, Palak Gosalia, Socorro Rodiles, John Holleran, Robert Ardecky, Stefan Grotegut, Steven Olson, John H. Hutchinson, Elena B. Pasquale, Kristiina Vuori, Aniruddha J. Deshpande, Nicholas D.P. Cosford, Lutz Tautz
Publikováno v:
The Journal of Biological Chemistry
Disturbance of the dynamic balance between tyrosine phosphorylation and dephosphorylation of signaling molecules, controlled by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is known to lead to the development of cancer. While mo
Autor:
Jian Xu, Manavi Chatterjee, Tyler D Baguley, Jonathan Brouillette, Pradeep Kurup, Debolina Ghosh, Jean Kanyo, Yang Zhang, Kathleen Seyb, Chimezie Ononenyi, Ethan Foscue, George M Anderson, Jodi Gresack, Gregory D Cuny, Marcie A Glicksman, Paul Greengard, TuKiet T Lam, Lutz Tautz, Angus C Nairn, Jonathan A Ellman, Paul J Lombroso
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001923 (2014)
STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38
Externí odkaz:
https://doaj.org/article/464c724e9a9e498caf07c3427d02b23b
Autor:
Sumeet Salaniwal, Nicholas D. P. Cosford, Maria Celeridad, Andrey A. Bobkov, Paul J. Lombroso, Palak Gosalia, Fu Yue Zeng, Stefan Grotegut, Ian Pass, Laurent J.S. De Backer, Lutz Tautz, Thomas D.Y. Chung, Lester J. Lambert
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4417, p 4417 (2021)
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4417, p 4417 (2021)
Many human diseases are the result of abnormal expression or activation of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Not surprisingly, more than 30 tyrosine kinase inhibitors (TKIs) are currently in clinical use and pr
Autor:
Nicole A Bakas, Lester J. Lambert, Nicholas D. P. Cosford, Mitchell Vamos, Huiyu Ren, Apirat Chaikuad, Reuben J. Shaw, Carina Wimer, Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Sonja N. Brun, Allison S. Limpert, Stefan Knapp
Publikováno v:
J Med Chem
Inhibition of autophagy, the major cellular recycling pathway in mammalian cells, is a promising strategy for the treatment of triple-negative breast cancer (TNBC). We previously reported SBI-0206965, a small molecule inhibitor of unc-51-like autopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4b2f1d43e7a3f43e170153e08bf32
https://europepmc.org/articles/PMC8064294/
https://europepmc.org/articles/PMC8064294/
Autor:
Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Nicholas D. P. Cosford, Lester J. Lambert, Celeste Romero
Publikováno v:
J Vis Exp
The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by the PTPN11 proto-oncogene, is a key mediator of receptor tyrosine kinase (RTK)-driven cell signaling, promoting cell survival and proliferation. In addition, SHP2 is recruite
Autor:
Dongmei Wu, Yuhong Pang, Yuehai Ke, Jianxiu Yu, Zhao He, Lutz Tautz, Tomas Mustelin, Sheng Ding, Ziwei Huang, Gen-Sheng Feng
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4914 (2009)
Recent studies have suggested distinctive biological properties and signaling mechanisms between human and mouse embryonic stem cells (hESCs and mESCs). Herein we report that Shp2, a protein tyrosine phosphatase with two SH2 domains, has a conserved
Externí odkaz:
https://doaj.org/article/d180a52e15cb4d95a246f4e111b84cb2
Autor:
Eduard Sergienko, Lester J. Lambert, Celeste Romero, Socorro Rodiles, Laurent J.S. De Backer, Douglas J. Sheffler, Elena B. Pasquale, Lutz Tautz, Stefan Grotegut, Nicholas D. P. Cosford, Dhanya Raveendra-Panickar, John Holleran, Maria Celeridad
Publikováno v:
J Biol Chem
The nonreceptor protein-tyrosine phosphatase (PTP) SHP2 is encoded by the proto-oncogene PTPN11 and is a ubiquitously expressed key regulator of cell signaling, acting on a number of cellular processes and components, including the Ras/Raf/Erk, PI3K/