Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lutz Nickau"'
Autor:
Lutz Nickau, Monika Anja Teermann
Publikováno v:
team.konkret. 15:17-21
Autor:
Karl-Heinz Baringhaus, Jurgen A. Horz, Lutz Nickau, Siegfried Schulz, Alfons Enhsen, Ernst Petzinger, Eugen Falk, Hoffmann Axel, Georg Neckermann, Günther Wess, Werner Kramer, Stefan Müllner, Heiner Glombik
Publikováno v:
Hepatology. 22:1801-1811
To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors HR 780 and lovastatin (syn. mevinolin) were conjugated with the bile acids cholic acid, taurocholic acid, an
Autor:
Ernst Petzinger, Klaus Bock, Axel Hoffman, Günther Wess, Dietrich Gantz, Georg Neckermann, Stephen D. Turley, Werner Kramer, Siefried Schulz, Lutz Nickau, Eugen Falk, Alfons Enhsen, John M. Dietschy
Publikováno v:
Biochimica et biophysica acta. 1227(3)
The target organ for HMG-CoA reductase inhibitors to decrease cholesterol biosynthesis in hypercholesterolemic patients is the liver. Since bile acids undergo an enterohepatic circulation showing a strict organotropism for the liver and the small int