Impact of elexacaftor/tezacaftor/ivacaftor on lung function, nutritional status, pulmonary exacerbation frequency and sweat chloride in people with cystic fibrosis: real-world evidence from the German CF RegistryResearch in context

Autor: Sivagurunathan Sutharsan, Stefanie Dillenhoefer, Matthias Welsner, Florian Stehling, Folke Brinkmann, Manuel Burkhart, Helmut Ellemunter, Anna-Maria Dittrich, Christina Smaczny, Olaf Eickmeier, Matthias Kappler, Carsten Schwarz, Sarah Sieber, Susanne Naehrig, Lutz Naehrlich, Klaus Tenbrock, Claus Pfannenstiel, Dirk Steffen, Jochen Meister, Britta Welzenbach, Anette Scharschinger, Markus Kratz, Maike Pincus, Tobias Tenenbaum, Mirjam Stahl, Kerstin Landwehr, Stefanie Dillenhöfer, Hans Kössel, Petra Kaiser, Manfred Käding, Simone Stolz, Stefan Blaas, Jutta Hammermann, Monika Gappa, Antje Schuster, Dana Spittel, Sabine Zirlik, Sabina Schmitt, Joachim Bargon, Malte Cremer, Sebastian Fähndrich, Andrea Heinzmann, Lutz Nährlich, Stefan Kuhnert, Sebastian Schmidt, Bettina Wollschläger, Anna Nolde, Inka Held, Wolfgang Kamin, Felix C. Ringshausen, Sabine Wege, Olaf Sommerburg, Norbert Geier, Sara Lisa Fleser, Heinrike Wilkens, Michael Lorenz, Paul Vöhringer, Martin Schebek, Christian Timke, Ingrid Bobis, Thomas Nüßlein, Doris Dieninghoff, Ernst Rietschel, Bastian Klinkhammer, Freerk Prenzel, Alexandra Wald, Axel Kempa, Eva Lücke, Ines Adams, Krystyna Poplawska, Simone Lehmkühler, Monika Bauck, Anne Pfülb, Rainald Fischer, Gudrun Schopper, Susanne Nährig, Matthias Griese, Jörg Grosse, Peter Küster, Birte KinderHolger Köster, Susanne Büsing, Margarethe Pohl, Andreas Artlich, Alexander Kiefer, Manfred Ballmann, Nikola Gjorgjevski, Markus A. Rose, Friederike Ruf, Rolf Mahlberg, Wolfgang Thomas, Ute Graepler, Sebastian Bode, hilipp Meyn, Josef Rosenecker, Cordula Koerner, Klaus-Michael Keller, Tina Teßmer, Helge Hebestreit, Gerhild Lohse

Publikováno v: The Lancet Regional Health. Europe, Vol 32, Iss , Pp 100690- (2023)

Summary: Background: Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) improves multiple clinical outcomes in people with cystic fibrosis (pwCF) with at least one F508del allele. This study evaluated the real-world impact of ETI on lung function,

Externí odkaz: https://doaj.org/article/cb7f1132ad9145b4909f1a838def4b95

Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients

Autor: Nils Wetzstein, Margo Diricks, Thomas A. Kohl, Thomas A. Wichelhaus, Sönke Andres, Laura Paulowski, Carsten Schwarz, Astrid Lewin, Jan Kehrmann, Barbara C. Kahl, Karl Dichtl, Christian Hügel, Olaf Eickmeier, Christina Smaczny, Annika Schmidt, Stefan Zimmermann, Lutz Nährlich, Sylvia Hafkemeyer, Stefan Niemann, Florian P. Maurer, Michael Hogardt

Publikováno v: Microbiology Spectrum, Vol 10, Iss 4 (2022)

ABSTRACT Infections due to Mycobacterium abscessus are a major cause of mortality and morbidity in cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved in person-to-person transmissions. In 2016, dominant global

Externí odkaz: https://doaj.org/article/6738412af9304c97bcbb8f38b2a682f1

Lung transplantation for end-stage cystic fibrosis before and after the availability of elexacaftor–tezacaftor–ivacaftor, Germany, 2012–2021

Autor: Felix C. Ringshausen, Annette Sauer-Heilborn, Tina Büttner, Anna-Maria Dittrich, Nicolaus Schwerk, Fabio Ius, Lutz Nährlich, Tobias Welte, Mark Greer

Publikováno v: European Respiratory Journal. 61:2201402

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7a9c9582c19c2cef4a01c49aca78f3
https://doi.org/10.1183/13993003.01402-2022

SARS-CoV-2 Antibodies in Children: A One-Year Seroprevalence Study From June 2020 to May 2021 in Germany

Autor: Anna-Lisa Sorg, Leon Bergfekd, Marietta Jank, Victor M. Corman, Ilia Semmler, Anna Görtz, Andreas Beyerlein, Eva Verjans, Norbert Wagner, Horst von Bernuth, Fabian Lander, Katharina Weil, Markus Hufnagel, Ute Spiekerkoetter, Chao Cho-Ming, Lutz Nährlich, Ania C. Muntau, Ulf Schulze-Sturm, Gesine Hansen, Martin Wetzke, Anna-Maria Jung, Tim Niehues, Susanne Fricke-Otto, Ulrich von Both, Johannes Hübner, Uta Behrends, Johannes G. Liese, Christian Schwerk, Christian Drosten, Rüdiger von Kries, Horst Schroten

Publikováno v: SSRN Electronic Journal.

Background: Investigating the role of children in the COVID-19 pandemic is pivotal to prevent the virus spreading. In most cases, children infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) develop non-specific symptoms or are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::370a95954bdb1e1debdf381c0da0e9e2
https://doi.org/10.2139/ssrn.3965378

The global impact of SARS-CoV-2 in 181 people with cystic fibrosis

Autor: Bell, Scott C, Reid, David, Wark, Peter, Braeckel, Eva Van, Gohy, Sophie, Knoop, Christiane, Pirson, Jessica, Wachter, Elke De, Dupont, Lieven, Hanssens, Laurence, Nowé, Vicky, Lequesne, Monique, Athanazio, Rodrigo A, Meneses, Daniela G, Boussaud, Véronique, Brinchault, Graziella, Coirier-Duet, Emmanuelle, Dubus, Jean-Christophe, Grenet, Dominique, Miranda, Sandra de, Beaumont, Laurence, Kanaan, Reem, Lauraens, Muriel, Martin, Clémence, Martin, Marie Mittaine, Prévotat, Anne, Reynaud-Gaubert, Martine, Sermet-Gaudelus, Isabelle, Tatopoulos, Aurelie, Chiron, Raphael, Dalphin, Marie-Laure, Gerardin, Michele, Weiss, Laurence, Wizla, Nathalie, Ramel, Sophie, Plant, Barry, Gunaratnam, Cedric, Jackson, Abaigeal, Casciaro, Rosaria, Lucca, Francesca, Daccò, Valeria, Folino, Anna, Manca, Antonio, Messore, Barbara, Morlacchi, Letizia, Pisi, Giovanna, Poli, Piercarlo, Amato, Annalisa, Ferrari, Gianluca, de Winter- de Groot, Karin, Luijk, Bart, Wesseling, Geertjan, Kondratyeva, Elena, Zhekayte, Elena, Amelina, Elena, Mukhina, Mariya, Simonova, Olga, Alvarez-Fernandez, Antonio, Sole-Jover, Amparo, Cortell-Aznar, Isidoro, Giron-Moreno, Rosa, Lopez-Neyra, Alejandro, Ramos-Cancelo, Isabel, Lzaro-Carrasco, Maite, Ruiz de Valbuena, Marta, Prados-Sanchez, Concepcin, Costa-Colomer, Jordi, Gartner, Silvia, Diab-Caceres, Layla, Gilljam, Marita, Lindberg, Ulrika, Diemer, Stefanie, Allenby, Mark, J Bourke, Stephen, C Charman, Susan, Collinson, Janet, Dempsey, Owen, Denniston, Sarah, Desai, Maya, Duckers, Jamie, Etherington, Christine, Gunn, Elaine, Higton, Alex, Ho, Timothy, Hull, Jeremy, Jones, Andrew, Ian Ketchell, Robert, Madge, Susan L., Maitra, Anirban, Mujtaba, Ghulam, Nash, Edward, Nazareth, Dilip, OBrien, Christopher, Onyon, Claire, Orchard, Christopher, Peckham, Daniel, Rodgers, Helen, Shafi, Nadia, Simmonds, Nicholas, Southern, Kevin, Walshaw, Martin, Watson, Danie, L Whitehouse, Joanna, McClenaghan, Elliot, Cosgriff, Rebecca, Brownlee, Keith, Ahern, Susannah, Burgel, Pierre-Régis, Byrnes, Catherine A, Colombo, Carla, Corvol, Harriet, Cheng, Stephanie Y, Daneau, Géraldine, Elbert, Alexander, Faro, Albert, Goss, Christopher H, Gulmans, Vincent, Gutierrez, Hector, de Monestrol, Isabelle, Jung, Andreas, Justus, Lutz Nährlich, Kashirskaya, Nataliya, Marshall, Bruce C, McKone, Edward, Middleton, Peter G, Mondejar-Lopez, Pedro, Pastor-Vivero, M Dolores, Padoan, Rita, Rizvi, Samar, Ruseckaite, Rasa, Salvatore, Marco, Stephenson, Anne L., Filho, Luiz Vicente R da Silva, Melo, Joel, Zampoli, Marco, Carr, Siobhán B

Publikováno v: In Journal of Cystic Fibrosis November 2020 19(6):868-871