Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lutz Mueller"'
Autor:
Natan Bar-Chama, Bakri Elsheikh, Channa Hewamadduma, Carol Jean Guittari, Ksenija Gorni, Lutz Mueller
Publikováno v:
Neurology and Therapy, Vol 13, Iss 4, Pp 933-947 (2024)
Abstract Spinal muscular atrophy (SMA) is a neuromuscular disease caused by deletions or mutations in the survival of motor neuron 1 (SMN1) gene resulting in reduced levels of SMN protein. SMN protein is produced by cells throughout the body, and evi
Externí odkaz:
https://doaj.org/article/f5bd081ed8f9402d83371c6ecdf5ed7a
Autor:
Olga Holubovska, Pavlo Babich, Alla Mironenko, Jens Milde, Yuriy Lebed, Holger Stammer, Lutz Mueller, Aartjan J. W. te Velthuis, Victor Margitich, Andrew Goy
Publikováno v:
Advances in Respiratory Medicine, Vol 92, Iss 3, Pp 202-217 (2024)
Enisamium is an orally available therapeutic that inhibits influenza A virus and SARS-CoV-2 replication. We evaluated the clinical efficacy of enisamium treatment combined with standard care in adult, hospitalized patients with moderate COVID-19 requ
Externí odkaz:
https://doaj.org/article/202cc218d64f4e9fb9263966c5a3df1f
Autor:
Maik Haupt, Nadja Jäkel, Maria Wachsmuth, Michael Stadler, Dietrich Beelen, Juergen Finke, Nael Alakel, Philipp Hemmati, Stefan Schönland, Wolfgang Bethge, Gerald Wulf, Daniel Wolff, Johanna Maria Tischer, Eva Wagner-Drouet, Anna Brandt, Nicolaus Kröger, Vladan Vucinic, Ben-Niklas Bärmann, Monika Brüggemann, Cora Gromann, Carsten Müller-Tidow, Nicola Gökbuget, Lutz Mueller
Publikováno v:
HemaSphere, Vol 7, p e85305e4 (2023)
Externí odkaz:
https://doaj.org/article/07366d2930ca47bcb5fbec29c886e435
Autor:
Eleonore Haltner-Ukomadu, Svitlana Gureyeva, Oleksii Burmaka, Andriy Goy, Lutz Mueller, Grygorii Kostyuk, Victor Margitich
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 1, p 3 (2018)
An investigation into the biopharmaceutics classification and a study of the in vitro bioavailability (permeability and solubility) of the antiviral compound enisamium iodide (4-(benzylcarbamoyl)-1-methylpyridinium iodide) were carried out. The solub
Externí odkaz:
https://doaj.org/article/aa8a88dce0c7441da1070f99cb5751cc
Publikováno v:
The Handbook of Medicinal Chemistry ISBN: 9781788018982
RNA as a drug target offers a wealth of opportunities to therapeutically modulate numerous cellular processes, including those linked to the so-called “undruggable” protein targets. Of particular interest is the modulation of the natural process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a873f6591c39f7929a54ddf6f4fe35
https://doi.org/10.1039/9781788018982-00830
https://doi.org/10.1039/9781788018982-00830
Autor:
Agnès Poirier, Heidemarie Kletzl, Cordula Stillhart, Stephen Fowler, Kenichi Umehara, Andreas Guenther, Andreas Brink, Nicole A. Kratochwil, Dietrich Tuerck, Christophe Husser, Mark Savage, Mohammed Ullah, Lutz Mueller, Yumi Cleary, Katja Heinig
Publikováno v:
Drug Metabolism and Disposition. 50:65-75
Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as potential therapeutics. Acquiring data through standard methods can yield results that are insufficient
Publikováno v:
Reproductive Toxicology. 118:108360
Autor:
Stephen, Fowler, Andreas, Brink, Yumi, Cleary, Andreas, Günther, Katja, Heinig, Christophe, Husser, Heidemarie, Kletzl, Nicole, Kratochwil, Lutz, Mueller, Mark, Savage, Cordula, Stillhart, Dietrich, Tuerck, Mohammed, Ullah, Kenichi, Umehara, Agnès, Poirier
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(1)
Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as potential therapeutics. Acquiring data through standard methods can yield results that are insufficient
Autor:
Frederico Sala, Cesare Cosentino, Olha Holubovska, Miguel Muzzio, Jindrich Cinatl, Victor Margitich, David Boltz, Aartjan J. W. te Velthuis, Lutz Mueller, Yuriy Lebed, Denisa Bojkova, Stefano Elli, Xinjian Peng, Holger Stammer, Alla Mironenko, Marco Guerrini, Jens Milde, Andrew Goy, Marco Bechtel
Publikováno v:
Biomedicines
medRxiv
article-version (status) pre
article-version (number) 1
medRxiv
article-version (status) pre
article-version (number) 1
Pandemic SARS-CoV-2 causes a mild to severe respiratory disease called Coronavirus Disease 2019 (COVID-19). Control of SARS-CoV-2 spread will depend on vaccine-induced or naturally acquired protective herd immunity. Until then, antiviral strategies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed77d3f92e3dc8c3d484bdad7a97e0e
https://doi.org/10.1101/2021.01.05.21249237
https://doi.org/10.1101/2021.01.05.21249237
Autor:
Gemma Tremolada, Lutz Mueller, Nora Denk, Birgit Jaber, Sabine Fürst-Recktenwald, Ksenija Gorni, Shannon Beres, Emmanuel Barreau, Melissa SantaMaria, Renata S. Scalco, Agnieszka Waskowska, Lorenzo Orazi, Steven Kane, Bjoern Jacobsen, Giulia Maria Amorelli, Stefania Bianchi Marzoli, Stephane Nave, Giovanni Baranello, Diletta Santarsiero, Shigeko Yashiro, Robert C. Sergott, Eugenio Mercuri, Marianne Gerber
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, 2021, 8 (1), pp.54-65. ⟨10.1002/acn3.51239⟩
Annals of Clinical and Translational Neurology, 2021, 8 (1), pp.54-65. ⟨10.1002/acn3.51239⟩
International audience; Objective: Evaluation of ophthalmologic safety with focus on retinal safety in patients with spinal muscular atrophy (SMA) treated with risdiplam (EVRYSDI®), a survival of motor neuron 2 splicing modifier associated with reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef0d410b8eb7a635f42594899d6af7e
https://ut3-toulouseinp.hal.science/hal-03639067
https://ut3-toulouseinp.hal.science/hal-03639067