Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Lutz Jermutus"'
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture
Autor:
Philipp Knyphausen, Mariana Rangel Pereira, Paul Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Custom proteases find applications as therapeutics, in research and in biotechnological applications. Here, the authors establish a protease selection system based on bacterial alpha-2-macroglobulin protease inhibitors and evolve staphylococcal prote
Externí odkaz:
https://doaj.org/article/4a5f0a823f2043db90aef3f41550275c
Publikováno v:
Physiological Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract The inotropic effects of glucagon have been recognized for many years, but it has remained unclear whether glucagon signaling is beneficial to cardiac function. We evaluated the effects of glucagon alone and in combination with the glucagon
Externí odkaz:
https://doaj.org/article/87b884012d2c4f36ac251561f7c20681
Autor:
Craig J Currie, Ellen R Berni, Thomas R Berni, Sara Jenkins-Jones, Marvin Sinsakul, Lutz Jermutus, Philip Ambery, Meena Jain
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221044 (2019)
Diabetes plays an important role in the complex relationship between chronic kidney disease (CKD) and cardiovascular disease. This retrospective observational study compared the influence of estimated glomerular filtration rate (eGFR) and proteinuria
Externí odkaz:
https://doaj.org/article/a2fb478743054edb9bd118fb4ba83174
Autor:
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://doaj.org/article/c7112dc536a744a789e3b298aa48181d
Autor:
Carl I Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna Grudzinska, Lutz Jermutus, Christin Andersson
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104001 (2014)
Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer's disease due to its ability to degrade the peptide amyloid beta. However, its broad
Externí odkaz:
https://doaj.org/article/d1ffb03507e3488eaa6fde76864289c9
Autor:
Sacha Zinn, Rodrigo Vazquez-Lombardi, Carsten Zimmermann, Puja Sapra, Lutz Jermutus, Daniel Christ
Publikováno v:
Nature Cancer. 4:165-180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb044d6a9981746f409135e4df8a33a
https://doi.org/10.1038/s43018-023-00516-z
https://doi.org/10.1038/s43018-023-00516-z
Publikováno v:
Biochemical Society Transactions
Many growth factors and cytokines are produced as larger precursors, containing pro-domains, that require proteolytic processing to release the bioactive ligand. These pro-domains can be significantly larger than the mature domains and can play an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0d30dd4cca0d3bc28ab3b8eb46cdce
https://doi.org/10.1042/bst20200663
https://doi.org/10.1042/bst20200663
Autor:
Hyosung Kim, Lutz Jermutus, Philip Ambery, Robert A. Gasser, Akiko Sekikawa, Michiko Asano, Marcella Petrone, Darren Robertson
Publikováno v:
Diabetes, Obesity and Metabolism. 23:1859-1867
Aim To evaluate the safety and pharmacokinetics of cotadutide, a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist, in overweight Asian participants with or without type 2 diabetes (T2D). Materials and methods In the phase 1, randomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fbad626f8a1c1450dea54293ced26d
https://doi.org/10.1111/dom.14412
https://doi.org/10.1111/dom.14412
Autor:
Victoria E. R. Parker, Thuong Hoang, Heike Schlichthaar, Fraser W. Gibb, Barbara Wenzel, Maximillian G. Posch, Ludger Rose, Yi‐Ting Chang, Marcella Petrone, Lars Hansen, Philip Ambery, Lutz Jermutus, Hiddo J. L. Heerspink, Rory J. McCrimmon
Publikováno v:
Diabetes, Obesity and Metabolism, 24(7), 1360-1369. Wiley
Aim: To assess the efficacy, safety and tolerability of cotadutide in patients with type 2 diabetes mellitus and chronic kidney disease.Materials and Methods: In this phase 2a study (NCT03550378), patients with body mass index 25-45 kg/m2, estimated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cce20fe3bbb9eb269a394e95e3ca3dc
https://pubmed.ncbi.nlm.nih.gov/35403793
https://pubmed.ncbi.nlm.nih.gov/35403793
Autor:
Lina Petersone, Chun Jing Wang, Ellen M. Ross, Martin Eichmann, Elisavet Ntavli, Alexandros Kogimtzis, Frank Heuts, Rupert Kenefeck, Natalie M. Edner, Niclas Thomas, Mark Peakman, Roman Baptista, Miranda Rosenthal, Yassin Elfaki, Lutz Jermutus, Lucy S. K. Walker, Vitalijs Ovcinnikovs, Philip Ambery
Publikováno v:
Nature Immunology. 21:1244-1255
Follicular helper T (TFH) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether TFH cells were decreased by costimulation blockade using the CTLA-4–immunoglobulin (Ig) fusion p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54bedb5eca58d2d9c16a6a91691e585d
https://doi.org/10.1038/s41590-020-0744-z
https://doi.org/10.1038/s41590-020-0744-z