Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lutz Franzen"'
Publikováno v:
Molecular Pharmaceutics. 19:1505-1514
Administration of highly concentrated monoclonal antibodies (mAbs) through injection is often not possible as the viscosity can be readily above 50 mPa·s when the concentration exceeds 150 mg/mL. Besides, highly concentrated mAb solutions always exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a4d503ca309c8ec3a8b090769dde23
https://doi.org/10.1021/acs.molpharmaceut.2c00039
https://doi.org/10.1021/acs.molpharmaceut.2c00039
Autor:
Christian Bender, Sabine Eichling, Lutz Franzen, Viktoria Herzog, Ludger M. Ickenstein, Dhananjay Jere, Lara Nonis, Gregoire Schwach, Philipp Stoll, Marta Venczel, Shalin Zenk
Publikováno v:
Journal of pharmaceutical sciences. 111(9)
For injectable biopharmaceuticals, the subcutaneous route of administration is increasingly preferred over intravenous administration. However, one of the challenges in the development of subcutaneously administered biopharmaceuticals is a reduced bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ff2bfcfee623bf850928f5e6ce7481
https://pubmed.ncbi.nlm.nih.gov/35429492
https://pubmed.ncbi.nlm.nih.gov/35429492
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 95:110-116
For rational development and evaluation of dermal drug delivery, the knowledge of rate and extent of substance penetration into the human skin is essential. However, current analytical procedures are destructive, labor intense and lack a defined spat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3250655e836ac58c99d81c43740e15a6
https://doi.org/10.1016/j.ejpb.2015.03.026
https://doi.org/10.1016/j.ejpb.2015.03.026
Autor:
Maike Windbergs, Lutz Franzen
Publikováno v:
Advanced Drug Delivery Reviews. 89:91-104
In the field of skin research, confocal Raman microscopy is an upcoming analytical technique. Substantial technical progress in design and performance of the individual setup components like detectors and lasers as well as the combination with confoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee055cd4e42f2c7aeec146ea600f8f7
https://doi.org/10.1016/j.addr.2015.04.002
https://doi.org/10.1016/j.addr.2015.04.002
Autor:
Lutz Franzen, Maike Windbergs
Publikováno v:
Journal of Raman Spectroscopy. 45:82-88
The opportunity of label-free and non-destructive detection of substances inside human skin by confocal Raman microscopy represents a novel approach for investigating drug penetration and permeation. Several studies already introduced confocal Raman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a92f007fe7ff22952df0bf6f39f1669c
https://doi.org/10.1002/jrs.4428
https://doi.org/10.1002/jrs.4428
Publikováno v:
Skin Pharmacology and Physiology. 25:249-256
To perform accurate tape-stripping measurements and to control for site-specific and interindividual differences the amount of stratum corneum (SC) removed by each tape and the total SC thickness must be known. The purpose of this study was to evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578cf5ee5c27a8434d6856953aed52ce
https://doi.org/10.1159/000339905
https://doi.org/10.1159/000339905
Publikováno v:
Experimental dermatology. 23(12)
In the area of dermatological research, the knowledge of rate and extent of substance penetration into the human skin is essential not only for evaluation of therapeutics, but also for risk assessment of chemicals and cosmetic ingredients. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b218ade606f82f3131cc28df5f84459
https://pubmed.ncbi.nlm.nih.gov/25219950
https://pubmed.ncbi.nlm.nih.gov/25219950
Publikováno v:
Skin pharmacology and physiology. 28(2)
Considering the increasing incidence of chronic wounds and severe wound infections, effective drug delivery to wounded skin is of high importance. The rational development of novel therapeutic systems requires appropriate in vitro testing methodologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86398a1f3f64ffdcb7a343beaa5105dc
https://pubmed.ncbi.nlm.nih.gov/25341368
https://pubmed.ncbi.nlm.nih.gov/25341368
Publikováno v:
Experimental dermatology. 22(1)
In vitro testing of drugs with excised human skin is a valuable prerequisite for clinical studies. However, the analysis of excised human skin presents several obstacles. Ongoing drug diffusion, microbial growth and changes in hydration state influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90e051aec98523ab53c7f13f7856648
https://pubmed.ncbi.nlm.nih.gov/23278895
https://pubmed.ncbi.nlm.nih.gov/23278895
Publikováno v:
Journal of Biomedical Optics. 18:061210
Hair follicles have recently gained a lot of interest for dermal drug delivery. They provide facilitated penetration into the skin and a high potential to serve as a drug depot. In this area of research, excised pig ear is a widely accepted in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3509a4a9207a199d1a4b8ea3012d44
https://doi.org/10.1117/1.jbo.18.6.061210
https://doi.org/10.1117/1.jbo.18.6.061210