Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

Autor: Voss, Felizia K., Ullrich, Florian, Münch, Jonas, Lazarow, Katina, Lutter, Darius, Mah, Nancy, Andrade-Navarro, Miguel A., von Kries, Jens P., Stauber, Tobias, Jentsch, Thomas J.

Publikováno v: Science, 2014 May 01. 344(6184), 634-638.

Externí odkaz: http://www.jstor.org/stable/24743881

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt‐based anti‐cancer drugs

Autor: Planells‐Cases, Rosa, Lutter, Darius, Guyader, Charlotte, Gerhards, Nora M., Ullrich, Florian, Reincke, S. Momsen, Stauber, Tobias, Blomen, Vincent A, Vis, Daniel J., Wessels, Lodewyk F., Brummelkamp, Thijn R., Borst, Piet, Rottenberg, Sven, Jentsch, Thomas J.

Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment, the determinants of tumor cell responsiveness remain poorly understood. We show that the loss of subunits LRRC8A and LRRC8D of the heteromeric LRRC8 volume‐regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4732::62b405ab5b05c502939be9742a5bd3e3
https://doi.org/10.17169/refubium-20775

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Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

Autor: Darius Lutter, Charlotte Guyader, S. Momsen Reincke, Deborah A Elger, Felizia K. Voss, Florian Ullrich, Vincent A. Blomen, Thomas J. Jentsch, Asli Kucukosmanoglu, Sven Rottenberg, Piet Borst, Daniel J. Vis, Guotai Xu, Lodewyk F. A. Wessels, Tobias Stauber, Thijn R. Brummelkamp, Nora M. Gerhards, Rosa Planells-Cases

Publikováno v: The EMBO journal, 34(24): 2985-3073
The EMBO Journal
EMBO Journal, 34(24), 2993-3008. Wiley-Blackwell
ResearcherID
Planells-Cases, Rosa; Lutter, Darius; Guyader, Charlotte; Gerhards, Nora Merete; Ullrich, Florian; Elger, Deborah A; Kucukosmanoglu, Asli; Xu, Guotai; Voss, Felizia K; Reincke, S Momsen; Stauber, Tobias; Blomen, Vincent A; Vis, Daniel J; Wessels, Lodewyk F; Brummelkamp, Thijn R; Borst, Piet; Rottenberg, Sven; Jentsch, Thomas J (2015). Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO Journal, 34(24), pp. 2993-3008. EMBO Press 10.15252/embj.201592409
Planells-Cases, R, Lutter, D, Guyader, C, Gerhards, N M, Ullrich, F, Elger, D A, Kucukosmanoglu, A, Xu, G, Voss, F K, Reincke, S M, Stauber, T, Blomen, V A, Vis, D J, Wessels, L F, Brummelkamp, T R, Borst, P, Rottenberg, S & Jentsch, T J 2015, ' Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs ', EMBO Journal, vol. 34, no. 24, pp. 2993-3008 . https://doi.org/10.15252/embj.201592409
EMBO JOURNAL

Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment, the determinants of tumor cell responsiveness remain poorly understood. We show that the loss of subunits LRRC8A and LRRC8D of the heteromeric LRRC8 volume‐regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a24fce2d0a948aa4340f62de1d8b6aa
http://www.scopus.com/inward/record.url?scp=84955178178&partnerID=8YFLogxK