Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Lutian Yao"'
Autor:
Zuozhen Tian, Frances S. Shofer, Mingyue Fan, Alec Z. Sandroni, Lutian Yao, Lin Han, Ling Qin, Motomi Enomoto-Iwamoto, Yejia Zhang
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101059- (2024)
Externí odkaz:
https://doaj.org/article/8e54348c408f41e080b362813cc2c8dc
Autor:
Jie Yang, Shanshan Li, Zhenyan Li, Lutian Yao, Meijing Liu, Kui‐Leung Tong, Qiutong Xu, Bo Yu, Rui Peng, Tao Gui, Wang Tang, Yidi Xu, Jiaxu Chen, Jun He, Kewei Zhao, Xiaogang Wang, Xiaoying Wang, Zhengang Zha, Huan‐Tian Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement in metabolic disorders, including diabetic osteoarthritis (DOA), is largely unk
Externí odkaz:
https://doaj.org/article/85f7e83775394f3ab501f3f6afdb21e1
Autor:
Lutian Yao, Jiawei Lu, Leilei Zhong, Yulong Wei, Tao Gui, Luqiang Wang, Jaimo Ahn, Joel D Boerckel, Danielle Rux, Christina Mundy, Ling Qin, Maurizio Pacifici
Publikováno v:
eLife, Vol 12 (2023)
Insufficient bone fracture repair represents a major clinical and societal burden and novel strategies are needed to address it. Our data reveal that the transforming growth factor-β superfamily member Activin A became very abundant during mouse and
Externí odkaz:
https://doaj.org/article/e2afbc82a06e4e92a58094be629da842
Autor:
Christina Mundy, Lutian Yao, Kelly A. Shaughnessy, Cheri Saunders, Eileen M. Shore, Eiki Koyama, Maurizio Pacifici
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Heterotopic ossification (HO) consists of extraskeletal bone formation. One form of HO is acquired and instigated by traumas or surgery, and another form is genetic and characterizes fibrodysplasia ossificans progressiva (FOP). Recently, we
Externí odkaz:
https://doaj.org/article/f17c27e7c498471f95ec93e2a5fac5b4
Autor:
Fangfang Song, Won Dong Lee, Tyler Marmo, Xing Ji, Chao Song, Xueyang Liao, Rebecca Seeley, Lutian Yao, Haoran Liu, Fanxin Long
Publikováno v:
eLife, Vol 12 (2023)
Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism is not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass is reduced due to diminished os
Externí odkaz:
https://doaj.org/article/2cba91af612b47da8b68cd4afe790ed5
Autor:
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Tao Gui, Michael Duffy, Nicholas Holdreith, Catherine A Bautista, Xiaobin Huang, Shovik Bandyopadhyay, Kai Tan, Chider Chen, Yongwon Choi, Jean X Jiang, Shuying Yang, Wei Tong, Nathanial Dyment, Ling Qin
Publikováno v:
eLife, Vol 12 (2023)
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We recently identi
Externí odkaz:
https://doaj.org/article/bb1b12b6a7ed4afd8c68a366c9066d9a
Autor:
Yejia Zhang, Zuozhen Tian, David Gerard, Lutian Yao, Frances S. Shofer, Gabriella Cs-Szabo, Ling Qin, Maurizio Pacifici, Motomi Enomoto-Iwamoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene ex
Externí odkaz:
https://doaj.org/article/29482a7dd36f42fc82304c841792897b
Autor:
Leilei Zhong, Lutian Yao, Nicholas Holdreith, Wei Yu, Tao Gui, Zhen Miao, Yehuda Elkaim, Mingyao Li, Yanqing Gong, Maurizio Pacifici, Amit Maity, Theresa M. Busch, Kyu Sang Joeng, Keith Cengel, Patrick Seale, Wei Tong, Ling Qin
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Radiation causes a collapse of bone marrow cells and elimination of microvasculature. To understand how bone marrow recovers after radiation, we focused on mesenchymal lineage cells that provide a supportive microenvironment for hematopoiesis and ang
Externí odkaz:
https://doaj.org/article/3e4aca805ba8470286d4476776986427
Autor:
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H Zgonis, Robert L Mauck, Jaimo Ahn, Ling Qin
Publikováno v:
eLife, Vol 10 (2021)
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mi
Externí odkaz:
https://doaj.org/article/f623562d2d094d8fa2bb24d452a21fa8
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
ObjectiveOsteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activator (RANKL) an
Externí odkaz:
https://doaj.org/article/ab2e720389f64a5eba4c5904c9e35f99