Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lutete Peguy, Khonde"'
Autor:
Vinayak Singh, Anna E. Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R. Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E. Lee, James C. Sacchettini, Inna V. Krieger, Mary Jackson, Kelly Chibale, Sandeep R. Ghorpade
Publikováno v:
ACS Infectious Diseases. 8:2315-2326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e365db73e0d90921758427a3c1ed96
https://doi.org/10.1021/acsinfecdis.2c00392
https://doi.org/10.1021/acsinfecdis.2c00392
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd5171702dfa2d1b82d5b9180cddebb
https://doi.org/10.1021/acs.jmedchem.1c00837
https://doi.org/10.1021/acs.jmedchem.1c00837
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
https://doi.org/10.1021/acs.jmedchem.1c00034
https://doi.org/10.1021/acs.jmedchem.1c00034
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9d052174dfa5e731d4d84ef57053ad6
https://pubmed.ncbi.nlm.nih.gov/34414766
https://pubmed.ncbi.nlm.nih.gov/34414766
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Autor:
André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa, John Okombo, Keletso Maepa, Timothy J. Egan, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 64:1762-1762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c147e8c41592066d856807fb5a89437
https://doi.org/10.1021/acs.jmedchem.1c00064
https://doi.org/10.1021/acs.jmedchem.1c00064
Autor:
Joanne J. Bronson, Mark A. Murcko, Erin L. Cole, Lindsey R. Drake, Sanju Narayanan, Rajendra Uprety, Rangan Maitra, Scott Runyon, Wu Yang, James R. Corte, Joseph M. Luettgen, Zhi-Liang Wei, Danielle L. Aubele, Kelly A. Pike, Ramsay Beveridge, Patrick Cyr, Alex Skeldon, Li Wang, Jason D. Burch, Karin Worm, Jill Henault, Mark David Andrews, Marcel John de Groot, Kevin Neil Dack, Min Lu, Rachel L. Palte, Scott N. Mlynarski, Jason D. Shields, Oliver Schadt, Guangxiu Dai, Weiguo Xiang, Xin Han, Lijie Zhao, Shaomeng Wang, Thomas P. Stratton, Alexandre Mercier, Emma Abernathy, Jason Hudlicky, Lutete Peguy Khonde, Paul Jackson, Peter R. Hewitt, Oliver Barker, Matthew D. Helm, Xavier Jacq, Colin R. O'Dowd, Natalie Page, J. S. Shane Rountree, Timothy Harrison, Anmol Gulati, Xin Guo, Anton Delwig, Noriko Ishisoko, Robert A. Blake, Jose Raul Montero Bastidas, Abdellatif El Marrouni, Maria Irina Chiriac, Thomas Struble, Dipannita Kalyani, Jeffrey A. Dodge, Michael J. Chalmers, Howard Broughton, Alfonso Espada, Joshua A. Lees, Seungil Han, Gene M. Dubowchik, Robe