N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

Autor: Li, Qike, Schissler, A. Grant, Gardeux, Vincent, Achour, Ikbel, Kenost, Colleen, Berghout, Joanne, Li, Haiquan, Zhang, Hao Helen, Lussier, Yves A.

Background: Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions, these methods are not desig

Externí odkaz: http://hdl.handle.net/10150/625841
http://arizona.openrepository.com/arizona/handle/10150/625841

A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis

Autor: Huang, Yong, Ma, Shwu-Fan, Vij, Rekha, Oldham, Justin M., Herazo-Maya, Jose, Broderick, Steven M., Strek, Mary E., White, Steven R., Hogarth, D. Kyle, Sandbo, Nathan K., Lussier, Yves A., Gibson, Kevin F., Kaminski, Naftali, Garcia, Joe G.N., Noth, Imre

BACKGROUND: The course of disease for patients with idiopathic pulmonary fibrosis (IPF) is highly heterogeneous. Prognostic models rely on demographic and clinical characteristics and are not reproducible. Integrating data from genomic analyses may i

Externí odkaz: http://hdl.handle.net/10150/610303
http://arizona.openrepository.com/arizona/handle/10150/610303

Epithelial cell responses to rhinovirus identify an early-life–onset asthma phenotype in adults

Autor: Chang, Eugene H., Pouladi, Nima, Guerra, Stefano, Jandova, Jana, Kim, Alexander, Li, Haiquan, Li, Jianrong, Morgan, Wayne, Stern, Debra A., Willis, Amanda L., Lussier, Yves A., Martinez, Fernando D.

Publikováno v: In The Journal of Allergy and Clinical Immunology September 2022 150(3):604-611

ExprTarget: An Integrative Approach to Predicting Human MicroRNA Targets

Autor: Gamazon, Eric R., Im, Hae-Kyung, Duan, Shiwei, Lussier, Yves A., Cox, Nancy J., Dolan, M. Eileen, Zhang, Wei

Publikováno v: Gamazon ER, Im H-K, Duan S, Lussier YA, Cox NJ, Dolan ME, Zhang W. ExprTarget: An integrative approach to predicting human microRNA targets. PLoS ONE. 2010; 5(10): e13534

We developed an online database, ExprTargetDB, of human miRNA targets predicted by an approach that integrates gene expression profiling into a broader framework involving important features of miRNA target site predictions.

Externí odkaz: http://arxiv.org/abs/1308.1865

Physician nurse care: A new use of UMLS to measure professional contribution: Are we talking about the same patient a new graph matching algorithm?

Autor: Boyd, Andrew D., Dunn Lopez, Karen, Lugaresi, Camillo, Macieira, Tamara, Sousa, Vanessa, Acharya, Sabita, Balasubramanian, Abhinaya, Roussi, Khawllah, Keenan, Gail M., Lussier, Yves A., Li, Jianrong ‘John’, Burton, Michel, Di Eugenio, Barbara

Publikováno v: In International Journal of Medical Informatics May 2018 113:63-71