Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lushen Li"'
Autor:
Lushen Li, Pankaj K. Mandal
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
β-hemoglobinopathies, including sickle cell disease (SCD) and β-thalassemia, are prevalent monogenic disorders causing abnormal hemoglobin structure or production that affect millions globally. Current available therapies for SCD and β-thalassemia
Externí odkaz:
https://doaj.org/article/d272331273064696b0f9a99d819f3a5b
Autor:
Bing Ma, Samuel J. Gavzy, Michael France, Yang Song, Hnin Wai Lwin, Allison Kensiski, Vikas Saxena, Wenji Piao, Ram Lakhan, Jegan Iyyathurai, Lushen Li, Christina Paluskievicz, Long Wu, Marina WillsonShirkey, Emmanuel F. Mongodin, Valeria R. Mas, Jonathan S. Bromberg
Publikováno v:
BMC Microbiology, Vol 23, Iss 1, Pp 1-21 (2023)
Abstract Intrinsic metabolism shapes the immune environment associated with immune suppression and tolerance in settings such as organ transplantation and cancer. However, little is known about the metabolic activities in an immunosuppressive environ
Externí odkaz:
https://doaj.org/article/c0e5f5a5daec4f3e9d4399354d544da1
Autor:
Joshua M. Gammon, Sean T. Carey, Vikas Saxena, Haleigh B. Eppler, Shannon J. Tsai, Christina Paluskievicz, Yanbao Xiong, Lushen Li, Marian Ackun-Farmmer, Lisa H. Tostanoski, Emily A. Gosselin, Alexis A. Yanes, Xiangbin Zeng, Robert S. Oakes, Jonathan S. Bromberg, Christopher M. Jewell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Antigen-specific tolerance represents a promising strategy to treat type 1 diabetes and islet allograft rejection. Here, the authors deliver immune signals to lymph nodes to promote antigen-specific regulatory T cells and prevent disease in models of
Externí odkaz:
https://doaj.org/article/2fe54bb72010401d8d7a7af2a350784f
Autor:
Bing Ma, Samuel J. Gavzy, Vikas Saxena, Yang Song, Wenji Piao, Hnin Wai Lwin, Ram Lakhan, Jegan Iyyathurai, Lushen Li, Michael France, Christina Paluskievicz, Marina W. Shirkey, Lauren Hittle, Arshi Munawwar, Emmanuel F. Mongodin, Jonathan S. Bromberg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract The beneficial effects attributed to Bifidobacterium are largely attributed to their immunomodulatory capabilities, which are likely to be species- and even strain-specific. However, their strain-specificity in direct and indirect immune mod
Externí odkaz:
https://doaj.org/article/f9fced7d73f84dbda470cc9023254a83
Autor:
Lushen Li, Long Wu, Allison Kensiski, Jing Zhao, Marina W. Shirkey, Yang Song, Wenji Piao, Tianshu Zhang, Zhongcheng Mei, Samuel J. Gavzy, Bing Ma, Vikas Saxena, Young S. Lee, Yanbao Xiong, Xiaofei Li, Xiaoxuan Fan, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Fibroblastic reticular cells (FRCs) play important roles in tolerance by producing laminin α4 (Lama4) and altering lymph node (LN) structure and function. The present study revealed the specific roles of extracellular matrix Lama4 in regulating LN c
Externí odkaz:
https://doaj.org/article/7dc3ca9c1b604d50926310b2f242e3f7
Autor:
Wenji Piao, Lushen Li, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Yigang Zhang, Isadora Tadeval Lape, Christina Paluskievicz, Keli L. Hippen, Young Lee, Emma Silverman, Marina W. Shirkey, Leonardo V. Riella, Bruce R. Blazar, Jonathan S. Bromberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The Programmed death-1 (PD-1) and its ligand PD-L1 are critical checkpoints in the regulation of immune responses. Here the authors implicate PD-L1 signalling at lymphatic endothelium in the regulation of transendothelial migration of T cells.
Externí odkaz:
https://doaj.org/article/95f1ec3c1b3240e0a0c30c1a91d6a299
Autor:
Jing Zhao, Sungwook Jung, Xiaofei Li, Lushen Li, Vivek Kasinath, Hengcheng Zhang, Said N. Movahedi, Ahmad Mardini, Gianmarco Sabiu, Yoonha Hwang, Vikas Saxena, Yang Song, Bing Ma, Sophie E. Acton, Pilhan Kim, Joren C. Madsen, Peter T. Sage, Stefan G. Tullius, George C. Tsokos, Jonathan S. Bromberg, Reza Abdi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transpla
Externí odkaz:
https://doaj.org/article/bc8427fba19b4be3b7fbe037cc02ca92
Autor:
Lushen Li, Marina W. Shirkey, Tianshu Zhang, Wenji Piao, Xiaofei Li, Jing Zhao, Zhongcheng Mei, Yizhan Guo, Vikas Saxena, Allison Kensiski, Samuel J. Gavzy, Yang Song, Bing Ma, Jing Wu, Yanbao Xiong, Long Wu, Xiaoxuan Fan, Holly Roussey, Meng Li, Alexæander S. Krupnick, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Lymph node (LN) fibroblastic reticular cells (FRCs) define LN niches and regulate lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components. We examined the role of ECM laminin α4 (Lama4) using FRC-Lama4 conditional KO P
Externí odkaz:
https://doaj.org/article/5d83d9a7e25f41368b6d68caa9682d5e
Autor:
Bing Ma, Samuel J. Gavzy, Vikas Saxena, Yang Song, Wenji Piao, Hnin Wai Lwin, Ram Lakhan, Jegan Iyyathurai, Lushen Li, Michael France, Christina Paluskievicz, Marina W. Shirkey, Lauren Hittle, Arshi Munawwar, Emmanuel F. Mongodin, Jonathan S. Bromberg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/00c7b31813ef492b96cdb8838282af9f
Autor:
Wenji Piao, Yanbao Xiong, Lushen Li, Vikas Saxena, Kile D. Smith, Keli L. Hippen, Christina Paluskievicz, Marina Willsonshirkey, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1052-1062.e5 (2020)
Summary: Regulatory T cells (Tregs) express high levels of cell surface lymphotoxin alpha beta (LTα1β2) to activate the LT beta receptor (LTβR) on the lymphatic endothelial cells (LECs), modulating LEC adhesion molecules, intercellular junctions,
Externí odkaz:
https://doaj.org/article/6876c6fb87d24c7797a8145af9f10501