Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Lurtotecan"'
Autor:
Mieke Ptaszynski, Elizabeth Abbott, Frank C. Richardson, Larry Dihel, Eric N. Brown, Jeremy D. Leray, John Desjardins, David L. Emerson, Raymond A. Bendele, Marta Hamilton, Blake Tomkinson
Publikováno v:
Anti-Cancer Drugs. 12:235-245
Prolonging tumor exposure to topoisomerase I inhibitors has been correlated to enhance the efficacy of those agents. Lurtotecan, a water-soluble camptothecin analog, was formulated as a liposomal drug, NX211, to enhance the delivery of drug to tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca091d9700dcb2a924e0a2f80950d332
https://doi.org/10.1097/00001813-200103000-00009
https://doi.org/10.1097/00001813-200103000-00009
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Evita van de Steeg, Cornelia M.M. van der Kruijssen, Kathryn E. Kenworthy, Jan H.M. Schellens, Roos L. Oostendorp
Publikováno v:
Drug Metabolism and Disposition. 37:917-923
Organic anion-transporting polypeptides (OATPs) are important uptake transporters that can have a profound impact on the systemic pharmacokinetics, tissue distribution, and elimination of several drugs. Previous in vivo studies of the pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff597441fe22687ccffb59ec6be1ccd
https://doi.org/10.1124/dmd.108.024901
https://doi.org/10.1124/dmd.108.024901
Publikováno v:
Update on Cancer Therapeutics. 1:117-145
Topoisomerase-1 is a key sub-cellular target for anti-cancer therapy. This intranuclear enzyme, responsible for DNA replication and repair, undergoes interaction with camptothecin and several semi-synthetic camptothecin analogs to produce cell-death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c94981e9613776ae172b24256cdf803
https://doi.org/10.1016/j.uct.2006.05.010
https://doi.org/10.1016/j.uct.2006.05.010
Autor:
Paul Vasey, Wendy Walsh, A. Hilary Calvert, Emma Barrett, Stan B. Kaye, R. Grimshaw, L. McIntosh, Gordon C Jayson, Graham Dark, Robert E. Coleman, Marc Trudeau, Tien Le, Christopher J. Poole, M. Hamilton, Susan Ellard, Terri Cameron, Elizabeth Eisenhauer, Ken D. Swenerton
Publikováno v:
Journal of Clinical Oncology. 23:1859-1866
Purpose Liposomal lurtotecan (OSI-211) is a liposomal formulation of the water-soluble topoisomerase I inhibitor lurtotecan (GI147211), which demonstrated superior levels of activity compared with topotecan in preclinical models. We studied two sched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e69cc5201fbb84fdde71c969c75b981
https://doi.org/10.1200/jco.2005.02.028
https://doi.org/10.1200/jco.2005.02.028
Publikováno v:
Expert Opinion on Drug Delivery. 2:323-333
In order to improve the therapeutic index of camptothecin (CPT) analogues, alternative administration of CPT analogues is being evaluated. Topotecan, irinotecan, rubitecan, lurtotecan and 9-aminocamptothecin have been administered orally with respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dcdb4c23407757803d8e9e97b1ba1f
https://doi.org/10.1517/17425247.2.2.323
https://doi.org/10.1517/17425247.2.2.323
Autor:
Benoit Baron, Pierre Fumoleau, C. Dittrich, Denis Lacombe, Markus Borner, M. Degardin, Jan B. Vermorken, Florence Duffaud, Ph. Chollet, J. Bloch, Frederic Rolland
Publikováno v:
European Journal of Cancer. 40:2748-2752
The purpose of this study was to evaluate the activity and safety of OSI-211, the liposomal form of lurtotecan, in patients ineligible for curative surgery or radiotherapy and with metastatic/locoregional recurrent squamous cell carcinoma of the head
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd1256c629a8ff93487ef641e43bf5a
https://doi.org/10.1016/j.ejca.2004.08.024
https://doi.org/10.1016/j.ejca.2004.08.024
Publikováno v:
Clinical Colorectal Cancer. 4:163-180
This article reviews the current status of the topoisomerase I (top I) inhibitors in the treatment of gastrointestinal (GI) malignancies. We focus on oral drug administration, the mode of administration that is generally preferred by patients with ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6374ff5a12e767412678d8857d7fd699
https://doi.org/10.3816/ccc.2004.n.017
https://doi.org/10.3816/ccc.2004.n.017
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 764:121-140
Camptothecin and congeners represent a clinically very useful class of anticancer agents. Proper identification and quantitation of the original compounds and their metabolites in biological fluids is fundamental to assess drug metabolism and distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519499259ce5d1ad6dd625859a3b9a4f
https://doi.org/10.1016/s0378-4347(01)00345-0
https://doi.org/10.1016/s0378-4347(01)00345-0
Publikováno v:
Anti-Cancer Drugs, 11, 315-324. Lippincott Williams & Wilkins
Several analogs of the topoisomerase I inhibitor camptothecin (CPT) have been introduced in clinical practice in the last decade. All CPT analogs are sensitive to a pH-dependent reversible conversion between a pharmacologically active lactone form an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1285f08e0afed8a1b0fb8687b3378d77
https://doi.org/10.1097/00001813-200006000-00001
https://doi.org/10.1097/00001813-200006000-00001
Autor:
Jaap Verweij, Walter J. Loos, Stan Gill, Peter de Bruijn, Marta Hamilton, Kees Nooter, Alex Sparreboom, Eric Brouwer, Diederik F. S. Kehrer, Gerrit Stoter
Publikováno v:
Journal of Chromatography B-Biomedical Applications, 738, 155-163. Elsevier
Lurtotecan (GI147211; LRT) is a semisynthetic and water-soluble analogue of the topoisomerase I inhibitor camptothecin. To determine whether the therapeutic efficacy of LRT in patients could be improved, the drug was encapsulated in liposomes (NX211;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be93f1ca8cd12a9434ff2140ade9031
https://doi.org/10.1016/s0378-4347(99)00513-7
https://doi.org/10.1016/s0378-4347(99)00513-7