Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Lurdes, Gano"'
Autor:
Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development relies on the e
Externí odkaz:
https://doaj.org/article/ff105247e7514a8eb2dac249aa0d9bfc
Autor:
Ana S. André, Joana N. R. Dias, Sandra Aguiar, Sara Nogueira, Pedro Bule, Joana Inês Carvalho, João P. M. António, Marco Cavaco, Vera Neves, Soraia Oliveira, Gonçalo Vicente, Belmira Carrapiço, Berta São Braz, Barbara Rütgen, Lurdes Gano, João D. G. Correia, Miguel Castanho, Joao Goncalves, Pedro M. P. Gois, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop mor
Externí odkaz:
https://doaj.org/article/f9c1a085d74e4cbdaf2217e2c95385f7
Autor:
Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Ana Leonardo, Sara Nogueira, Joana D. Amaral, Célia Fernandes, Lurdes Gano, João D. G. Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionCancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparati
Externí odkaz:
https://doaj.org/article/e1ae62f371ba4be582f085b5e995f720
Autor:
Alice D’Onofrio, Francisco Silva, Lurdes Gano, Paula Raposinho, Célia Fernandes, Arkadiusz Sikora, Monika Wyczółkowska, Renata Mikołajczak, Piotr Garnuszek, António Paulo
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2569 (2022)
Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxi
Externí odkaz:
https://doaj.org/article/be3a8061859940269765896c9e48ff68
Autor:
Alice D'Onofrio, Francisco Silva, Lurdes Gano, Urszula Karczmarczyk, Renata Mikołajczak, Piotr Garnuszek, António Paulo
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Pre-targeting approaches based on the inverse-electron-demand Diels-Alder (iEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have emerged in recent years as valid alternatives to classic targeted strateg
Externí odkaz:
https://doaj.org/article/95098ce148764a879ccdc6ecda980801
Autor:
Sandra Isabel Aguiar, Joana N. R. Dias, Ana Santos André, Marta Lisete Silva, Diana Martins, Belmira Carrapiço, Miguel Castanho, João Carriço, Marco Cavaco, Maria Manuela Gaspar, Rui Jorge Nobre, Luís Pereira de Almeida, Soraia Oliveira, Lurdes Gano, João D. G. Correia, Carlos Barbas, João Gonçalves, Vera Neves, Frederico Aires-da-Silva
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1598 (2021)
A major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of molecules that can cross the blood-brain barrier (BBB). Nano-delivery strategies are a promising approach that take advantage of nat
Externí odkaz:
https://doaj.org/article/d5051f93f2de446f9499ae1e868ed9eb
Autor:
Joana N R Dias, Ana S André, Sandra I Aguiar, Joana Ministro, Joana Oliveira, Maria C Peleteiro, Barbara Rütgen, Lurdes Gano, João D G Correia, Soraia S Oliveira, Joao Goncalves, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208147 (2018)
Canine diffuse large B-cell lymphoma (DLBCL) is one of the most common cancers in dogs which shares remarkable similarities with its human counterpart, making the dog an excellent model for the investigation of novel therapeutic agents. However, the
Externí odkaz:
https://doaj.org/article/c79f1b674fd54b3b8e5b4f00439ed35e
Autor:
Francisco Silva, Carolina Mendes, Alice D'Onofrio, Maria Paula Cabral Campello, Fernanda Marques, Teresa Pinheiro, Kyle Gonçalves, Sérgio Figueiredo, Lurdes Gano, Mauro Ravera, Elisabetta Gabano, António Paulo
Publikováno v:
Nanotheranostics. 7(1)
Over the last decades, gold nanoparticles (AuNPs) have proven to be remarkable tools for drug delivery and theranostic applications in cancer treatment. On the other hand, Pt(IV) prodrugs have been employed as an interesting alternative to the more c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6f8213f21052602c09c10f30dabf24
https://pubmed.ncbi.nlm.nih.gov/36593794
https://pubmed.ncbi.nlm.nih.gov/36593794
Autor:
Jacinta O. Pinho, Mariana Matias, Vanda Marques, Carla Eleutério, Célia Fernandes, Lurdes Gano, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, João Nuno Moreira, Gert Storm, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 157
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2929ee5d4512b6043d3c56cd1697be74
https://pubmed.ncbi.nlm.nih.gov/36399831
https://pubmed.ncbi.nlm.nih.gov/36399831
Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo
Autor:
Lurdes Gano, Marco Cavaco, João D. G. Correia, Darren Wragg, Vera Neves, Vera F. C. Ferreira, Tânia S. Morais, Claudia Schmidt, Rúben D M Silva, Filipa Mendes, Angela Casini, Ben Woods
Publikováno v:
Bioconjugate Chemistry. 32:1399-1408
The biomedical application of discrete supramolecular metal-based structures, specifically self-assembled metallacages, is still an emergent field of study. Capitalizing on the knowledge gained in recent years on the development of 3-dimensional (3D)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffcc9aee0c5117cf608c2fd096783cc1
https://doi.org/10.1021/acs.bioconjchem.0c00659
https://doi.org/10.1021/acs.bioconjchem.0c00659