Protective effect of genistein pre-treatment on paraquat hepatotoxicity in rats

Autor: Semeniuk, Mariana, Ceré, Lucila Inés, Ciriaci, Nadia, Bucci-Muñoz, María, Quiroga, Ariel Dario, Luquita, Marcelo Gabriel, Roma, Stella, Catania, Viviana Alicia, Mottino, Aldo Domingo, Rigalli, Juan Pablo, Ruiz, María Laura

Publikováno v: In Toxicology and Applied Pharmacology 1 September 2021 426

Acetaminophen Inhibits Intestinal P-Glycoprotein Transport Activity

Autor: Novak, Analia, Delli Carpini, Griselda, Ruiz, Maria Laura, Luquita, Marcelo Gabriel, Rubio, Modesto Carlos, Mottino, Aldo Domingo, Ghanem, Carolina Inés

Repeated acetaminophen (AP) administration modulates intestinal P-glycoprotein (P-gp) expression. Whether AP can modulate P-gp activity in a short-term fashion is unknown. We investigated the acute effect of AP on rat intestinal P-gp activity in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::2f6b3417116989cdb9b0f1d8820405d2
Wiley Online Library

Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance

Autor: Guillermo Nicolás Tocchetti, Maite Rocío Arana, Juan Pablo Rigalli, Pablo Domizi, Silvina Stella Maris Villanueva, Marcelo G. Luquita, María Laura Ruiz, Aldo D. Mottino, Claudia Banchio, Agostina Arias

Publikováno v: Toxicology and Applied Pharmacology. 287:178-190

The cAMP pathway is a universal signaling pathway regulating many cellular processes including metabolic routes, growth and differentiation. However, its effects on xenobiotic biotransformation and transport systems are poorly characterized. The effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e373f154f66ee9ce594ab0dd2fd45ad
https://doi.org/10.1016/j.taap.2015.06.003

Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Autor: Carolina Inés Ghanem, Marcelo G. Luquita, Aldo D. Mottino, María Paula Ceballos, María Laura Ruiz, Silvina Stella Maris Villanueva, Viviana A. Catania, Juan Pablo Rigalli, Agostina Arias, Nadia Ciriaci

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 10, Iss 3, p e0119502 (2015)
PLoS ONE

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e16c4343f246714938d4ec2539a9097
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119502

Hormonal Modulation of Hepatic cAMP Prevents Estradiol 17β-d-Glucuronide-Induced Cholestasis in Perfused Rat Liver

Autor: Marcelo G. Luquita, Enrique J. Sánchez Pozzi, Ismael Ricardo Barosso, Andrea Carolina Boaglio, Marcelo G. Roma, A.E. Zucchetti, Fernando A. Crocenzi

BACKGROUND: Estradiol-17β-D-glucuronide (E17G) induces cholestasis in vivo, endocytic internalization of the canalicular transporters multidrug resistance-associated protein 2 (Abcc2) and bile salt export pump (Abcb11) being a key pathomechanism. Cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14be89ff6ab91d36e43b884aefd6a450
http://link.springer.com/article/10.1007/s10620-013-2558-4