Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase II LOTIS-2 study

Autor: Paolo F. Caimi, Weiyun Z. Ai, Juan Pablo Alderuccio, Kirit M. Ardeshna, Mehdi Hamadani, Brian Hess, Brad S. Kahl, John Radford, Melhem Solh, Anastasios Stathis, Pier Luigi Zinzani, Ying Wang, Yajuan Qin, Luqiang Wang, Zhiying Cindy Xu, Carmelo Carlo-Stella

Publikováno v: Haematologica, Vol 109, Iss 4 (2023)

Therapies that demonstrate durable, long-term responses with manageable safety and tolerability are needed for patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Loncastuximab tesirine (loncastuximab tesirine-lpyl [Lonca]),

Externí odkaz: https://doaj.org/article/bd44e81cc44e4e969307a93b7e55be0c

Risk factors for pulmonary cement embolism after percutaneous vertebroplasty and radiofrequency ablation for spinal metastases

Autor: Luqiang Wang, Ming Lu, Xinxin Zhang, Zhenguo Zhao, Xiaoyang Li, Ting Liu, Libin Xu, Shengji Yu

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

ObjectivePulmonary cement embolism is a rare but underestimated complication of vertebroplasty due to the relative lack of study and examination. This study aims to investigate the incidence of pulmonary cement embolism in patients with spinal metast

Externí odkaz: https://doaj.org/article/6627018dcb2b444fb9d88016c58c0897

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

Autor: Leilei Zhong, Lutian Yao, Robert J Tower, Yulong Wei, Zhen Miao, Jihwan Park, Rojesh Shrestha, Luqiang Wang, Wei Yu, Nicholas Holdreith, Xiaobin Huang, Yejia Zhang, Wei Tong, Yanqing Gong, Jaimo Ahn, Katalin Susztak, Nathanial Dyment, Mingyao Li, Fanxin Long, Chider Chen, Patrick Seale, Ling Qin

Publikováno v: eLife, Vol 9 (2020)

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors an

Externí odkaz: https://doaj.org/article/e1bde3bf4480496eb8cd45466e510294

Short Cyclic Regimen With Parathyroid Hormone ( PTH ) Results in Prolonged Anabolic Effect Relative to Continuous Treatment Followed by Discontinuation in Ovariectomized Rats

Autor: Wei‐Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Wenzheng Wang, Chantal MJ Bakker, Yihan Li, Carlos Osuna, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X Sherry Liu

Publikováno v: J Bone Miner Res

Despite the potent effect of intermittent parathyroid hormone (PTH) treatment on promoting new bone formation, bone mineral density (BMD) rapidly decreases upon discontinuation of PTH administration. To uncover the mechanisms behind this adverse phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124b1afc3e8278827a1e29e21d3c0de6
https://doi.org/10.1002/jbmr.4495

Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma

Autor: Melhem Solh, Karin Havenith, Jay Feingold, Brad S. Kahl, Erin Reid, Luqiang Wang, Carmelo Carlo-Stella, Leonard T. Heffner, John Radford, Owen A. O'Connor, Paolo Caimi, William Townsend, Joseph Boni, Kirit M. Ardeshna, David Ungar, Yajuan Gu Qin, Mehdi Hamadani

Publikováno v: Blood
Hamadani, M, Radford, J, Carlo-Stella, C, Caimi, P F, Reid, E G, O'Connor, O A, Feingold, J, Ardeshna, K M, Townsend, W M, Solh, M, Heffner, L T, Ungar, D, Wang, L, Boni, J P, Havenith, K, Qin, Y G & Kahl, B 2021, ' Final Results of a Phase 1 Study of Loncastuximab Tesirine in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma ', Blood, vol. 137, no. 19, pp. 2634-2645 . https://doi.org/10.1182/blood.2020007512

The prognosis for patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL) remains poor, with a need for alternatives to current salvage therapies. Loncastuximab tesirine (ADCT-402) is an antibody-drug conjugate comprising a hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b478dd36863d89191135470f4ddaa
https://doi.org/10.1182/blood.2020007512