Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Luqia Hou"'
Autor:
Peter Lee, Luqia Hou, Faisal J. Alibhai, Rasha Al-attar, Ana Simón-Chica, Andrés Redondo-Rodríguez, Yilin Nie, Maria Mirotsou, Michael A. Laflamme, Gayathri Swaminath, David Filgueiras-Rama
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Scalable and high-throughput electrophysiological measurement systems are necessary to accelerate the elucidation of cardiac diseases in drug development. Optical mapping is the primary method of simultaneously measuring several key electrophysiologi
Externí odkaz:
https://doaj.org/article/e5d5130d469c4b4893bbfb543e3a095b
Autor:
Luqia Hou, Mohit Kumar, Priti Anand, Yinhong Chen, Nesrine El-Bizri, Chad J. Pickens, W. Michael Seganish, Sakthivel Sadayappan, Gayathri Swaminath
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously published cMyBP-
Externí odkaz:
https://doaj.org/article/b15ebb87cdaf439295dcec183101f5d9
Autor:
Luqia Hou, Joseph J. Kim, Maureen Wanjare, Bhagat Patlolla, John Coller, Vanita Natu, Trevor J. Hastie, Ngan F. Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Endothelial cells derived from human pluripotent stem cells are a promising cell type for enhancing angiogenesis in ischemic cardiovascular tissues. However, our understanding of microenvironmental factors that modulate the process of endoth
Externí odkaz:
https://doaj.org/article/b834ecd2de884f21b8fd182ebae0603e
Autor:
Luqia Hou, Guang Yang, Shibing Tang, Cynthia Alcazar, Prajakta Joshi, Zachary Strassberg, Michael Kim, Masashi Kawamura, Y. Joseph Woo, Joseph Shrager, Sheng Ding, Ngan F. Huang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 18 (2018)
Background CEP (ω‐[2‐carboxyethyl]pyrrole) protein adducts are the end products of lipid oxidation associated with inflammation and have been implicated in the induction of angiogenesis in pathological conditions such as tissue ischemia. We synt
Externí odkaz:
https://doaj.org/article/d9376b0256134fdc882c48b06417cfdd
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55400 (2013)
The use of genetic engineering of unexcitable cells to enable expression of gap junctions and inward rectifier potassium channels has suggested that cell therapies aimed at establishing electrical coupling of unexcitable donor cells to host cardiomyo
Externí odkaz:
https://doaj.org/article/2cf8885cbb75476a91c2bfddb8a4e836
Autor:
Kuljeet Kaur, Manuel Zarzoso, Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Luqia Hou, Hassan Musa, José Jalife
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55391 (2013)
Cardiac injury promotes fibroblasts activation and differentiation into myofibroblasts, which are hypersecretory of multiple cytokines. It is unknown whether any of such cytokines are involved in the electrophysiological remodeling of adult cardiomyo
Externí odkaz:
https://doaj.org/article/b1f951ccac53468783038c11c3a93b0b
Autor:
Michael Seganish, Luqia Hou, Sakthivel Sadayappan, Mohit Kumar, Yinhong Chen, Chad J Pickens, Priti Anand, Gayathri Swaminath, Nesrine El-Bizri
Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Although reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients, direct modulation of cMyBP-C to myosin us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226ef3701f3b627a49f4b41b4d5428c6
https://doi.org/10.21203/rs.3.rs-955920/v1
https://doi.org/10.21203/rs.3.rs-955920/v1
Autor:
Joseph J. Kim, Lydia M. Joubert, Maureen Wanjare, Ngan F. Huang, Nicholas P. Mezak, Luqia Hou, Guang Yang
Publikováno v:
Cellular and Molecular Bioengineering. 10:417-432
Human induced pluripotent stem cells (iPSCs) are a promising source of endothelial cells (iPSC-ECs) for engineering three-dimensional (3D) vascularized cardiac tissues. To mimic cardiac microvasculature, in which capillaries are oriented in parallel,
Autor:
Joseph J. Kim, Joseph C. Wu, Ngan F. Huang, Nicholas P. Mezak, Karina H. Nakayama, Evangeline Tzatzalos, Maureen Wanjare, Oscar J. Abilez, Luqia Hou
Publikováno v:
Biomaterials Science. 5:1567-1578
Engineering of myocardial tissue constructs is a promising approach for treatment of coronary heart disease. To engineer myocardial tissues that better mimic the highly ordered physiological arrangement and function of native cardiomyocytes, we gener
Publikováno v:
Acta Biomaterialia. 41:17-26
Engineering of three-dimensional (3D) tissues is a promising approach for restoring diseased or dysfunctional myocardium with a functional replacement. However, a major bottleneck in this field is the lack of efficient vascularization strategies, bec