Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring

Autor: Sofie Vestergaard Fonager, Gudrun Winther, Thomas Rea Wittenborn, Lisbeth Jensen, Cecilia Fahlquist-Hagert, Lisbeth Ahm Hansen, Ernst-Martin Füchtbauer, Marina Romero-Ramos, Søren Egedal Degn

Publikováno v: Fonager, S V, Winther, G, Wittenborn, T R, Jensen, L, Fahlquist-Hagert, C, Hansen, L A, Füchtbauer, E-M, Romero-Ramos, M & Degn, S E 2022, ' Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring ', Journal of Neuroimmunology, vol. 370, 577927 . https://doi.org/10.1016/j.jneuroim.2022.577927

Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba039347c7a63e48b99862576184d6f7
https://pure.au.dk/portal/da/publications/increased-maternofoetal-transfer-of-antibodies-in-a-murine-model-of-systemic-lupus-erythematosus-but-no-immune-activation-and-neuroimmune-sequelae-in-offspring(5e13c1cc-0e1d-4d3c-9a81-c7c6d064d5ae).html

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Autor: Charlotte Möller, Gregory J. Buchan, Francisco J. Schopfer, Rachel E. Rigby, Hiroyuki Arai, Jonathan J. Miner, Wei Qian, Anne L. Thielke, Camilla Gunderstofte, Martin R. Jakobsen, Jan Rehwinkel, Jessica Roos, Mona Motwani, Sonia R. Salvatore, Katherine A. Fitzgerald, Marie B. Iversen, Rongtuan Lin, Raphaela Goldbach-Mansky, Christian K. Holm, Michael Rühl, Kojiro Mukai, Thorsten J. Maier, Tomohiko Taguchi, Cathrine A. Miner, Andreas S. Jakobsen, Anne-Louise S. Hansen, Emari Ogawa, David Olagnier, Sidsel D. Andersen

Publikováno v: Hansen, A L, Buchan, G J, Rühl, M, Mukai, K, Salvatore, S R, Ogawa, E, Andersen, S D, Iversen, M B, Thielke, A L, Gunderstofte, C, Motwani, M, Møller, C T, Jakobsen, A S, Fitzgerald, K A, Roos, J, Lin, R, Maier, T J, Goldbach-Mansky, R, Miner, C A, Qian, W, Miner, J J, Rigby, R E, Rehwinkel, J, Jakobsen, M R, Arai, H, Taguchi, T, Schopfer, F J, Olagnier, D & Holm, C K 2018, ' Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 33, pp. E7768-E7775 . https://doi.org/10.1073/pnas.1806239115
Proceedings of the National Academy of Sciences of the United States of America

Significance Several chronic inflammatory conditions have recently been shown to depend on abnormally high activity of the signaling protein stimulator of IFN genes (STING). These conditions include examples from systemic lupus erythematosus, Aicardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7de5e98d88f9543f4ef4e8fec446d2
https://doi.org/10.1073/pnas.1806239115

Genetic susceptibility to PolyI:C-induced IFNα/β-dependent accelerated disease in lupus-prone mice

Autor: B. L. Kotzin, Michael T. Falta, Trine N. Jørgensen, Johne Kappler, Pilippa Marrack, S. A. Flannery, Troy E. Metzger, Shozo Izui, Joshua M. Thurman

Publikováno v: Genes and Immunity, Vol. 7, No 7 (2006) pp. 555-567

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology. Associations between viral infections and the onset of SLE have been suggested, and recent studies have provided evidence that type I interferons (IFNalpha/beta) might p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861c38bc875c34fa163cebeda313413c
https://doi.org/10.1038/sj.gene.6364329

A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

Autor: Chenghui Huang, Susan Yung, Gongping Liang, Qianjin Lu, Rong Xiao, Tak Mao Chan, Ming Zhao, Yaping Li

Publikováno v: Clinical and Developmental Immunology, Vol 2013 (2013)
Clinical and Developmental Immunology

The aberrant activity of CD4(+) T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes. Our previous studies demonstrated that Gadd45a contributes to the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6eaff4ae16a1eb0f04d31df934380a
https://doaj.org/article/b31b71eb425743c796350ff07b7cb2d1

The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice

Autor: Masahiro Iwamoto, M. E. Gershwin, Ramón Merino, Shozo Izui

Publikováno v: Journal of Clinical Investigation, Vol. 94, No 2 (1994) pp. 521-525

To investigate the specific contribution of select MHC class II genes on the development of murine lupus, H-2 congenic (NZB x BXSB)F1 hybrid mice bearing either H-2b/b, H-2d/b, or H-2d/d haplotypes were generated. We compared the clinical development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a071b352e4ec61c51607a1f8c766f21
https://doi.org/10.1172/jci117364