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Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.

Autor: Wurtz NR; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Johnson JA; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Viet A; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Shirude PS; Biocon Bristol Myers Squibb R&D Center, Bangalore-560099, India., Baligar V; Biocon Bristol Myers Squibb R&D Center, Bangalore-560099, India., Madduri S; Biocon Bristol Myers Squibb R&D Center, Bangalore-560099, India., Cheney DL; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Park H; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Lupisella JA; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Hsu MY; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Abousleiman M; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Galella MA; Bristol Myers Squibb Research and Development, New Brunswick, New Jersey 08901, United States., Aulakh D; Bristol Myers Squibb Research and Development, New Brunswick, New Jersey 08901, United States., Dierks EA; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Garcia RA; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Ostrowski J; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Kick EK; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States., Wexler RR; Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 May 25; Vol. 13 (6), pp. 943-948. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022).

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.

Autor: García RA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA.; Department of Medicine, University of California-San Diego, San Diego, California, USA., Lupisella JA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ito BR; Department of Medicine, University of California-San Diego, San Diego, California, USA., Hsu MY; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Fernando G; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Carson NL; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Allocco JJ; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ryan CS; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Zhang R; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wang Z; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Heroux M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Carrier M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., St-Onge S; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Bouvier M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada., Dudhgaonkar S; Biocon Bristol Myers Squibb Research Center, Bangalore, India., Nagar J; Biocon Bristol Myers Squibb Research Center, Bangalore, India., Bustamante-Pozo MM; Department of Medicine, University of California-San Diego, San Diego, California, USA., Garate-Carrillo A; Department of Medicine, University of California-San Diego, San Diego, California, USA., Chen J; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ma X; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Search DJ; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Dierks EA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Kick EK; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wexler RR; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Gordon DA; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Ostrowski J; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Wurtz NR; Department of Cardiovascular and Fibrosis Drug Discovery, Bristol Myers Squibb, Princeton, New Jersey, USA., Villarreal F; Department of Medicine, University of California-San Diego, San Diego, California, USA.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2021 Aug 23; Vol. 6 (8), pp. 676-689. Date of Electronic Publication: 2021 Aug 23 (Print Publication: 2021).

11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.

Autor: García RA; Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America., Search DJ, Lupisella JA, Ostrowski J, Guan B, Chen J, Yang WP, Truong A, He A, Zhang R, Yan M, Hellings SE, Gargalovic PS, Ryan CS, Watson LM, Langish RA, Shipkova PA, Carson NL, Taylor JR, Yang R, Psaltis GC, Harrity TW, Robl JA, Gordon DA

Publikováno v: PloS one [PLoS One] 2013; Vol. 8 (2), pp. e53192. Date of Electronic Publication: 2013 Feb 01.