Zobrazeno 1 - 10
of 26
pro vyhledávání: '"LuoQuan Ao"'
Autor:
Min He, Xiang Ao, Yu Yang, Yanmin Xu, Tao Liu, Luoquan Ao, Wei Guo, Wei Xing, Jing Xu, Cheng Qian, Jianhua Yu, Xiang Xu, Ping Yi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 58, Iss , Pp 101065- (2024)
Introduction: Ovarian cancer is the most malignant gynecological tumor. Previous studies have demonstrated that chimeric antigen receptor (CAR)-engineered NK-92 cells targeting folate receptor α (αFR) (NK-92-αFR-CAR) can specifically kill αFR-pos
Externí odkaz:
https://doaj.org/article/a2f599d0b05b4011a921980b779a4d27
Autor:
Weijun Wan, Xiang Ao, Quan Chen, Yang Yu, Luoquan Ao, Wei Xing, Wei Guo, Xiaofeng Wu, Chengxiu Pu, Xueting Hu, Zhan Li, Mengwei Yao, Donglin Luo, Xiang Xu
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Continual expression of PD-L1 in tumor cells is critical for tumor immune escape and host T cell exhaustion, however, knowledge on its clinical benefits through inhibition is limited in breast cancer. N6-methyladenosine (m6A) play
Externí odkaz:
https://doaj.org/article/2240f804a2f14c4daf36201b4c10a65f
Autor:
Hang Ruan, Xiangyun Li, Xiang Xu, Brian J Leibowitz, Jingshan Tong, Lujia Chen, Luoquan Ao, Wei Xing, Jianhua Luo, Yanping Yu, Robert E Schoen, Nahum Sonenberg, Xinghua Lu, Lin Zhang, Jian Yu
Publikováno v:
eLife, Vol 9 (2020)
To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, bu
Externí odkaz:
https://doaj.org/article/8097d9190a1f4efdac858b6f81908cd6
Autor:
Zhan Li, Mu Yuan, Xueting Hu, Wei Xing, XiaoFeng Wu, ChengXiu Pu, Wei Guo, XiYan Zhu, MengWei Yao, LuoQuan Ao, Xiang Xu
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 26
Background: High altitude pulmonary edema (HAPE) is a serious mountain sickness with certain mortality. Its early diagnosis is very important. However, the mechanism of its onset and progression is still controversial. Purpose: This study aimed to an
Autor:
Zhilin Shen, Zhengcheng Wang, Min He, Luoquan Ao, Xiang Xu, Xiang Ao, Ling Li, Hongfeng Yuan, Wei Guo, Chengxiu Pu, Xiaofeng Wu, Wei Xing, Jianhua Yu
Publikováno v:
International Journal of Biological Sciences
Chronic inflammation-induced metastases have long been regarded as one of the significant obstacles in treating cancer. Tumor necrosis factor-α (TNF-α), a main inflammation mediator within tumor microenvironment, affects tumor development by induci
Autor:
Mengwei Yao, Zhuo Chen, Xiao He, Jiaoyue Long, Xuewei Xia, Zhan Li, Yu Yang, Luoquan Ao, Wei Xing, Qizhou Lian, Huaping Liang, Xiang Xu
Publikováno v:
Life science alliance. 5(12)
The immunosuppressive function “licensed” by IFN-γ is a vital attribute of mesenchymal stem cells (MSCs) widely used in the treatment of inflammatory diseases. However, the mechanism and impact of metabolic reprogramming on MSC immunomodulatory
Autor:
Yan Tan, Mengwei Yao, Song Guo Zheng, Yi Yang, Wei Guo, Xiang Xu, Xiaofeng Wu, Joseph A. Bellanti, Lei Yang, Wei Xing, Zhan Li, Xueting Hu, Luoquan Ao, Xiao He
Publikováno v:
Annals of the Rheumatic Diseases. 79:1298-1304
ObjectivesTo clarify the key role of circulating interferon-γ (IFN-γ) and to improve the clinical efficacy of mesenchymal stem cell (MSC) transplantation (MSCT) in patients with rheumatoid arthritis (RA).MethodsStudy of wild-type or IFN-γR-/- MSCT
Autor:
Weijun, Wan, Xiang, Ao, Quan, Chen, Yang, Yu, Luoquan, Ao, Wei, Xing, Wei, Guo, Xiaofeng, Wu, Chengxiu, Pu, Xueting, Hu, Zhan, Li, Mengwei, Yao, Donglin, Luo, Xiang, Xu
Publikováno v:
Molecular cancer. 21(1)
Continual expression of PD-L1 in tumor cells is critical for tumor immune escape and host T cell exhaustion, however, knowledge on its clinical benefits through inhibition is limited in breast cancer. NMeRIP-seq and epitranscriptomic microarray ident
Autor:
Xiaofeng Wu, Xiao He, Luoquan Ao, Jianxin Guo, Weiqiang Li, Yan Tan, Yu Yang, Xiang Xu, Jianchuan Xia, Wei Guo, Xiang Ao
Publikováno v:
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Folate receptor alpha (αFR) is overexpressed in 90% of ovarian cancers, one of the most lethal gynecologic cancers. Recent studies have suggested that natural killer (NK) cells may be better chimeric antigen receptor (CAR) drivers because of their f
Autor:
Wei Guo, Shang-ze Li, Yan Tan, Rong-sen Zhao, Xiang Ao, Mengwei Yao, Zhan Li, Xiaofeng Wu, Mu Yuan, Jian Yu, Xueting Hu, Luoquan Ao, Wei Xing, Xiang Xu
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Background Emerging evidence suggests that epithelial mesenchymal transition (EMT) and epigenetic mechanisms promote metastasis. Histone deacetylases (HDACs) and noncoding RNAs (ncRNAs) are important epigenetic regulators. Here, we elucidated a novel