Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

Autor: Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike

Publikováno v: Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)

Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad

Externí odkaz: https://doaj.org/article/38eeb434d83440d7b7cd474042626a72

A Versatile Platform to Analyze Low-Affinity and Transient Protein-Protein Interactions in Living Cells in Real Time

Autor: Luo Wei Rodewald, Pavel Safar, Christian Hoppmann, Kenneth F. Wertman, Marcel Patek, Lei Wang, Sylvain Lebreton, Ee Tsin Wong, Geoffrey M. Wahl, Yao-Cheng Li

Publikováno v: Cell Reports, Vol 9, Iss 5, Pp 1946-1958 (2014)
Cell reports, vol 9, iss 5

Summary: Protein-protein interactions (PPIs) play central roles in orchestrating biological processes. While some PPIs are stable, many important ones are transient and hard to detect with conventional approaches. We developed ReBiL, a recombinase en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a0cab3adb4513a20058c44648d3ed
http://www.sciencedirect.com/science/article/pii/S2211124714009279

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

Autor: Geoffrey M. Wahl, Payal Desai, Roeland Nusse, Michael T. Lewis, Jennifer L. Green, Mathias Leblanc, Justin La, Luo-Wei Rodewald, Xiaomei Zhang, Kyu Won Yum

Publikováno v: Proceedings of the National Academy of Sciences. 110:6991-6996

Wnt signaling in mouse mammary development and tumorigenesis has been heavily studied and characterized, but its role in human breast cancer remains elusive. Although Wnt inhibitors are in early clinical development, it is unclear whether they will b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec2cf562c3b3ff0fae103c0e3d3f9a5
https://doi.org/10.1073/pnas.1303671110

Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation

Autor: Mark Wade, Yunyuan V. Wang, Yao-Cheng Li, Luo Wei Rodewald, EeTsin Wong, Geoffrey M. Wahl

Publikováno v: Proceedings of the National Academy of Sciences. 104:12365-12370

P53 regulates numerous downstream targets to induce cell cycle arrest, senescence, apoptosis, and DNA repair in response to diverse stresses. Hdm2 and Hdmx are critical negative regulators of P53 because Hdm2 regulates P53 abundance, and both can ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db245fd3762ab15d9199ad00a3e2b0ce
https://doi.org/10.1073/pnas.0701497104

Mouse Mutants Reveal that Putative Protein Interaction Sites in the p53 Proline-Rich Domain Are Dispensable for Tumor Suppression

Autor: Luo-Wei Rodewald, Crystal J. Lee, Chung-Wen Liu, Franck Toledo, Geoffrey M. Wahl, Kurt A. Krummel

Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, 2007, 27 (4), pp.1425-1432. ⟨10.1128/mcb.00999-06⟩
Molecular and Cellular Biology, American Society for Microbiology, 2007, 27 (4), pp.1425-1432. ⟨10.1128/mcb.00999-06⟩

International audience; The stability and activity of tumor suppressor p53 are tightly regulated and partially depend on the p53 proline-rich domain (PRD). We recently analyzed mice expressing p53 with a deletion of the PRD (p53(DeltaP)). p53(DeltaP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469d38b6458ea1f01362ab2b6766f153
https://www.hal.inserm.fr/inserm-03198993/document