Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo

Autor: He, Yu ^{a, 1}, Luo, Yinheng ^{a, 1}, Huang, Lan ^{a, 1}, Zhang, Dan ^a, Hou, Huijin ^a, Liang, Yue ^a, Deng, Shi ^b, Zhang, Peng ^b, Liang, Shufang ^{a, ∗}

Publikováno v: In European Journal of Medicinal Chemistry 5 March 2024 267

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

RREB1-mediated SUMOylation enhancement promotes chemoresistance partially by transcriptionally upregulating UBC9 in colorectal cancer.

Autor: Deng YN; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Chen Y; Department of Medical Oncology, Suining First People's Hospital, Suining, Sichuan, China., Gao S; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Zhang N; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China., Luo Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Luo S; Department of Medical Oncology, Suining First People's Hospital, Suining, Sichuan, China., Li Q; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China., Fu X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Liang S; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jul 23; Vol. 15, pp. 1381860. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).