Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Lunzhi, Dai"'
Autor:
Wenkang Fu, Yanyan Lin, Mingzhen Bai, Jia Yao, Chongfei Huang, Long Gao, Ningning Mi, Haidong Ma, Liang Tian, Ping Yue, Yong Zhang, Jinduo zhang, Yanxian Ren, Liyun Ding, Lunzhi Dai, Joseph W. Leung, Jinqiu Yuan, Wenhua Zhang, Wenbo Meng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3931-3948 (2024)
Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of the ribosomal protein S6 (RPS6) gene, which is dependent in CCA. We found that RPS6 upregulation in CCA tissues was correla
Externí odkaz:
https://doaj.org/article/14fb145ecfbb4eaf95fc86109a774fc8
Autor:
Bin Xia, Qiangsheng He, Fang Gao Smith, V. Georgios Gkoutos, Krishnarajah Nirantharakumar, Zi Chong Kuo, Danni Wang, Qi Feng, Eddie C. Cheung, Lunzhi Dai, Junjie Huang, Yuanyuan Yu, Wenbo Meng, Xiwen Qin, Jinqiu Yuan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Proton pump inhibitors (PPIs) are commonly used for gastric acid-related disorders, but their safety profile and risk stratification for high-burden diseases need further investigation. Analyzing over 2 million participants from five prospec
Externí odkaz:
https://doaj.org/article/d7b4a54fc4af40e8ba59087f6ff20e42
Autor:
Yingfeng Tu, Qin Yang, Min Tang, Li Gao, Yuanhao Wang, Jiuqiang Wang, Zhe Liu, Xiaoyu Li, Lejiao Mao, Rui zhen Jia, Yuan Wang, Tie-shan Tang, Pinglong Xu, Yan Liu, Lunzhi Dai, Da Jia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Liver kinase B1 (LKB1), an evolutionarily conserved serine/threonine kinase, is a master regulator of the AMPK subfamily and controls cellular events such as polarity, proliferation, and energy homeostasis. Functions and mechanisms of the LK
Externí odkaz:
https://doaj.org/article/1003e6c99c3f49bfa3199ad69e3c8016
Autor:
Qing Hao, Ruicen Li, Hancong Li, Shu Rui, Liting You, Lingyun Zhang, Yue Zhao, Peiheng Li, Yuanmin Li, Xinagyu Kong, Haining Chen, Xiuhe Zou, Feng Liu, Xiaofei Wang, Juan Zhou, Weihan Zhang, Libing Huang, Yang Shu, JiaYe Liu, Ronghao Sun, Chao Li, Jingqiang Zhu, Yong Jiang, Tao Wei, Kun Qian, Bing Bai, Yiguo Hu, Yong Peng, Lunzhi Dai, Carlos Caulin, Heng Xu, Zhihui Li, Jihwan Park, Han Luo, Binwu Ying
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract γδ T cells are evolutionarily conserved T lymphocytes that manifest unique antitumor efficacy independent of tumor mutation burden (TMB) and conventional human leukocyte antigen (HLA) recognition. However, the dynamic changes in their T ce
Externí odkaz:
https://doaj.org/article/eba6f12e4c9f44d3829f21ff3ee0623f
Autor:
Kewei Qin, Shuhan Yu, Yang Liu, Rongtian Guo, Shiya Guo, Junjie Fei, Yuemeng Wang, Kaiyuan Jia, Zhiqiang Xu, Hu Chen, Fengtian Li, Mengmeng Niu, Mu-Shui Dai, Lunzhi Dai, Yang Cao, Yujun Zhang, Zhi-Xiong Jim Xiao, Yong Yi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for t
Externí odkaz:
https://doaj.org/article/e870a2212b0b4d6ab060b6b47dd7a212
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to skeletal ageing. The process of skeletal ageing can be accelerated by reduced proliferation and osteogenesis of bone marrow mesenchymal stem cells (BM-MS
Externí odkaz:
https://doaj.org/article/8ce6a5ff051946bab4b58815829987a3
Autor:
Qian Zhong, Kun Zheng, Wanmeng Li, Kang An, Yu Liu, Xina Xiao, Shan Hai, Biao Dong, Shuangqing Li, Zhenmei An, Lunzhi Dai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1212-1227 (2023)
Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising, protecting joints and many other aspects. Moreover, muscle is also an
Externí odkaz:
https://doaj.org/article/8e3ed225be1f4028bd07261d3fcdd43d
Autor:
Kang Chen, Fei Tang, Bin Du, Zhe‐Zhou Yue, Ling‐Ling Jiao, Xu‐Long Ding, Qing‐Zhang Tuo, Jie Meng, Si‐Yu He, Lunzhi Dai, Peng Lei, Xia‐Wei Wei
Publikováno v:
MedComm, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase activity was observed in sporadic PD. Therefore, inhibition of LRRK
Externí odkaz:
https://doaj.org/article/32e62c3f8e794c19a0b5ef7bb8bcde66
Autor:
Tao Chen, Zhen Zhou, Minge Peng, Huifang Hu, Rui Sun, Jiayi Xu, Chenxi Zhu, Yanhong Li, Qiuping Zhang, Yubin Luo, Bin Yang, Lunzhi Dai, Yi Liu, Luis E. Muñoz, Liesu Meng, Martin Herrmann, Yi Zhao
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Neutrophils have a critical role in the pathogenesis of rheumatoid arthritis (RA) with immune system dysfunction. However, the molecular mechanisms of this process mediated by neutrophils still remain elusive. The purpose of the p
Externí odkaz:
https://doaj.org/article/01640364dbb94ddf94bd1b9e72e96e8d
Autor:
Kui Wang, Li Luo, Shuyue Fu, Mao Wang, Zihao Wang, Lixia Dong, Xingyun Wu, Lunzhi Dai, Yong Peng, Guobo Shen, Hai-Ning Chen, Edouard Collins Nice, Xiawei Wei, Canhua Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation
Externí odkaz:
https://doaj.org/article/a8cf977e10a64602a434646123cf3d01