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Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study

Autor: Chouliaras, L, Pishva, E, Haapakoski, R, Zsoldos, E, Mahmood, A, Filippini, N, Burrage, J, Mill, J, Kivimäki, M, Lunnon, K, Ebmeier, K

Publikováno v: Epigenomics, 10(5), 585-595. Future Medicine Ltd.

Background DNA methylation (DNAm) has been linked with the pathophysiology of brain aging, cognitive impairment and dementia. Methods The present study investigated the association between blood genome-wide DNAm profiles, cognitive dysfunction and br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a8d2939aa59053ba802bd07bc06145f6
https://www.repository.cam.ac.uk/handle/1810/275755

Invited Review – A 5‐year update on epigenome‐wide association studies of DNA modifications in Alzheimer's disease: progress, practicalities and promise.

Autor: Smith, A. R., Wheildon, G., Lunnon, K.

Publikováno v: Neuropathology & Applied Neurobiology; Dec2020, Vol. 46 Issue 7, p641-653, 13p

Influence of coding variability in APP-Aß metabolism genes in sporadic Alzheimer's disease

Autor: Sassi, C., Ridge, P., Nalls, M.A., Gibbs, R., Ding, J., Lupton, M.K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K.S., Medway, C., Lord, J., Morgan, Kevin, Turton, James, Powell, J.F., Kauwe, J.S., Cruchaga, C., Bras, J., Goate, A.M., Singleton, A., Guerreiro, Rita, Hardy, J.

The cerebral deposition of Aß42, a neurotoxic proteolitic derivate of amyloid precursor protein (APP), is a central event in Alzheimer’s disease (AD)(Amyloid hypothesis). Given the key role of APP-Aß metabolism in AD pathogenesis, we selected 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2cbd7d2f5f7fa7fc86c49b01c5bf44a5
http://eprints.nottingham.ac.uk/33347/

Tissue-specific patterns of allelically-skewed DNA methylation

Autor: Marzi, S., Meaburn, Emma L., Dempster, E.L., Lunnon, K., Paya-Cano, J., Smith, R., Volta, M., Troakes, C., Schalkwyk, L.C., Mill, J.

Publikováno v: Marzi, S, Meaburn, E L, Dempster, E L, Lunnon, K S, Paya Cano, J L, Smith, R G, Volta, M, Troakes, C, Schalkwyk, L C & Mill, J 2016, ' Tissue-specific patterns of allelically-skewed DNA methylation ', Epigenetics : official journal of the DNA Methylation Society, vol. 11, no. 1, pp. 24-35 . https://doi.org/10.1080/15592294.2015.1127479

While DNA methylation is usually thought to be symmetrical across both alleles, there are some notable exceptions. Genomic imprinting and X chromosome inactivation are two well-studied sources of allele-specific methylation (ASM), but recent research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0789e8ec77bc15dbc3bebac1d4c7e343
https://kclpure.kcl.ac.uk/en/publications/d6679d47-e6ff-4faf-9af8-c4d0e84ebefe