Isotoxic Intensity Modulated Radiation Therapy in Stage III Non-Small Cell Lung Cancer: A Feasibility Study

Autor: W David J Ryder, Catherine Harris, Stephen Harrow, Kate Haslett, Corinne Faivre-Finn, P. McCloskey, Matthew Hatton, Fiona McDonald, N. Bayman, Gerard G Hanna, N. Groom, Kevin Franks, Susan Harden

Publikováno v: International Journal of Radiation Oncology, Biology, Physics
Haslett, K, Bayman, N, Franks, K, Groom, N, Harden, S V, Harris, C, Hanna, G, Harrow, S, Hatton, M, McCloskey, P, McDonald, F, Ryder, W D & Faivre-Finn, C 2021, ' Isotoxic Intensity Modulated Radiation Therapy in Stage III Non-Small Cell Lung Cancer: A Feasibility Study ', International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1341-1348 . https://doi.org/10.1016/j.ijrobp.2020.11.040

Purpose: Not all patients with stage III non-small cell lung cancer (NSCLC) are suitable for concurrent chemoradiation therapy (CRT). Local failure rate is high for sequential concurrent CRT. As such, there is a rationale for treatment intensificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f83fe444374fe5bf2850e3159812db
https://doi.org/10.1016/j.ijrobp.2020.11.040

Assessment of Treatment Effects and Long-term Benefits in Immune Checkpoint Inhibitor Trials Using the Flexible Parametric Cure Model

Autor: Filleron, Thomas, Bachelier, Marine, Mazieres, Julien, Pérol, Maurice, Meyer, Nicolas, Martin, Elodie, Mathevet, Fanny, Dauxois, Jean-Yves, Porcher, Raphaël, Delord, Jean-Pierre

Publikováno v: JAMA Network Open
JAMA Network Open, 2021, 4 (12), pp.e2139573. ⟨10.1001/jamanetworkopen.2021.39573⟩

International audience; ImportanceCompared with standard cytotoxic therapies, randomized immune checkpoint inhibitor (ICI) phase 3 trials reveal delayed benefits in terms of patient survival and/or long-term response. Such outcomes generally violate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::2cba5cacb81de819c5077ec65e762a0b
https://hal.science/hal-03842894/document

Comparison of cohort smoking intensities in Denmark and the Netherlands

Autor: Barendregt Jan J., Looman Caspar W.N., Brønnum-Hansen Henrik

Publikováno v: Bulletin of the World Health Organization, Vol 80, Iss 1, Pp 26-32 (2002)

OBJECTIVE: To assess the usefulness of the general framework of the smoking epidemic. METHODS: We use lung cancer mortality as an indicator for smoking intensity and employ an age-cohort model to accommodate the long-lasting and cumulative effects. R

Externí odkaz: https://doaj.org/article/3813966727524702933e7c592870ecf6

Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung

Autor: Mario P. Tschan, Anna M. Schläfli, Sabina Berezowska, Ralph A. Schmid, Tereza Losmanová, Magali Humbert, Félice A. Janser, Rupert Langer, Christina Neppl, Igor Tokarchuk

Publikováno v: Oxidative Medicine and Cellular Longevity
Losmanová, Tereza; Janser, Félice A.; Humbert, Magali; Tokarchuk, Igor; Schläfli, Anna M.; Neppl, Christina; Schmid, Ralph; Tschan, Mario P.; Langer, Rupert; Berezowska, Sabina (2020). Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung. Oxidative medicine and cellular longevity, 2020, p. 8506572. Hindawi 10.1155/2020/8506572
Oxidative medicine and cellular longevity, vol. 2020, pp. 8506572
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)

LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f7c444a62405c2d5a9f291e5553505
http://europepmc.org/articles/PMC7527932

Directions for robotic surgery in the treatment of thoracic diseases in Brazil

Autor: Jefferson Luiz Gross

Publikováno v: Jornal Brasileiro de Pneumologia
Jornal Brasileiro de Pneumologia, Vol 46, Iss 1 (2020)
Jornal Brasileiro de Pneumologia, Volume: 46, Issue: 1, Article number: e20190427, Published: 02 MAR 2020

Objective: To describe the morbidity, mortality, and rate of complete resection associated with robotic surgery for the treatment of non-small cell lung cancer in Brazil, as well as to report the rates of overall survival and disease-free survival in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688a2d8d35f53d5066b50e8d3a2d6c8e
https://doi.org/10.1590/1806-3713/e20190427