Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lung cell differentiation"'
Autor:
Shirley Lehnert, Ahmed M. Maria, Monica Serban, Issam El Naqa, Sangkyu Lee, N. Ybarra, Ola M. Maria, Sergio Faria, Mostafa Y. Shalaby, K. Jeyaseelan, Jessica R. Perez, Jan Seuntjens
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 24:283-295
Lung tissue exposure to ionizing irradiation can invariably occur during the treatment of a variety of cancers leading to increased risk of radiation-induced lung disease (RILD). Mesenchymal stem cells (MSCs) possess the potential to differentiate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c07aac8eb2ba50f32d6ebb77cc298a
https://doi.org/10.1097/pai.0000000000000180
https://doi.org/10.1097/pai.0000000000000180
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833:2690-2702
TTF-1 is an important transcription factor in lung development and lung disease and is essential for lung cell differentiation, specifically surfactant protein (Sftp) expression. The molecular mechanisms that drive the expression and transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cab46a13f180236c9f57c8a57e428d8
https://doi.org/10.1016/j.bbamcr.2013.06.030
https://doi.org/10.1016/j.bbamcr.2013.06.030
Autor:
Marion Huth, Manolis Pasparakis, Stephan Tenbaum, Angel R. Nebreda, Juan-Jose Ventura, Eusebio Perdiguero, Carmen Guerra, Mariano Barbacid
Publikováno v:
Nature Genetics. 39:750-758
Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation of lung stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b416c6fe837932a5c22eb6714debe3d
https://doi.org/10.1038/ng2037
https://doi.org/10.1038/ng2037
Autor:
Carol J. Blaisdell, Jeffrey A. Whitsett, William Checkley, Parviz Minoo, Qing S. Lin, Steven H. Abman, Marlene Rabinovitch, Lawrence S. Prince, Maya E. Kumar, Chris Kintner, Jeff Reese, Robert H. Lane, Zena Werb, Wellington V. Cardoso, Richard D. Bland, Jonathan A. Epstein, Thomas J. Mariani, Harold A. Chapman, Xin Sun, Kurt H. Albertine, Wei Shi, Donald M. McDonald, Dorothy B. Gail, Yoh Suke Mukouyama, Xingbin Ai, Edward E. Morrisey, Janet Rossant
Publikováno v:
Annals of the American Thoracic Society, vol 10, iss 2
Development of the pulmonary system is essential for terrestrial life. The molecular pathways that regulate this complex process are beginning to be defined, and such knowledge is critical to our understanding of congenital and acquired lung diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd435867a4243c4715438f14d4c948e
https://escholarship.org/uc/item/3hc1c69p
https://escholarship.org/uc/item/3hc1c69p
Autor:
Jung Woo Kang, Bum Joon Park, Han Woong Lee, Min Jung Kim, Jung Min Han, Sunghoon Kim, Lee Sang-Won, Jae Hyun Park, Hyoung June Kim, Young-Sun Kang
Publikováno v:
Nature Genetics. 34:330-336
p38 is associated with a macromolecular tRNA synthetase complex. It has an essential role as a scaffold for the complex, and genetic disruption of p38 in mice causes neonatal lethality. Here we investigated the molecular mechanisms underlying lethali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a19d61612501e8aecad9dca7c858a
https://doi.org/10.1038/ng1182
https://doi.org/10.1038/ng1182
Autor:
Paula Meleady, Martin Clynes
Publikováno v:
Cell Communication & Adhesion. 8:45-59
Integrins are a family of transmembrane glycoproteins that participate in a wide range of cellular events including proliferation, apoptosis and differentiation. Little is known about the mechanisms that control integrin subunit expression in epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdae99f650ad988ca8dd6ddc35a26fec
https://doi.org/10.3109/15419060109080706
https://doi.org/10.3109/15419060109080706
Autor:
Sash T. Cavin, Eric N. Olson, Frank W. Booth, Timothy J. McDonnell, Maria C. Marin, Brian S. Tseng, Ian J. Butler
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 22:304-315
Although fetal breathing movements are required for normal lung development, there is uncertainty concerning the specific effect of absent fetal breathing movements on pulmonary cell maturation. We set out to evaluate pulmonary development in a genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300da2fc3adc70c22513cbd272740b02
https://doi.org/10.1165/ajrcmb.22.3.3708
https://doi.org/10.1165/ajrcmb.22.3.3708
Autor:
Alvin M. Malkinson, Andrius Kazlauskas, Stephanie E. Porter, Pamela L. Rice, Kelli M. Koski, David S. Schrump, Aaron Chen, Gayatri Ramakrishna
Publikováno v:
Molecular Carcinogenesis. 25:285-294
The roles of growth factors in mouse lung neoplasia were investigated by examining receptors for platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) in epithelial cell lines. Whereas nontumorigenic lung cells expressed mRNA and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f83ecb777a852caf67cef47ced6ef12
https://doi.org/10.1002/(sici)1098-2744(199908)25:4<285::aid-mc7>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199908)25:4<285::aid-mc7>3.0.co
Autor:
Andrew Berglund, Emily A. Travanty, Yoko Ito, Kathryn V. Holmes, Robert J. Mason, Zhaohui Qian, Karen E. Edeen, Lauren M. Oko, Jieru Wang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Severe acute respiratory syndrome (SARS)-coronavirus (CoV) produces a devastating primary viral pneumonia with diffuse alveolar damage and a marked increase in circulating cytokines. One of the major cell types to be infected is the alveolar type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1ceb3b4d4792998d8129c5df0702f9
https://europepmc.org/articles/PMC3727876/
https://europepmc.org/articles/PMC3727876/
Stretch-induced differentiation of lung fetal type II epithelial cells is mediated through EGFR (ErbB1) via release of HB-EGF and TGF-α ligands. Employing an EGFR knock-out mice model, we further investigated the role of the ErbB family of receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c1ef1e182727d2dfca042ebf2a690e
https://europepmc.org/articles/PMC3365737/
https://europepmc.org/articles/PMC3365737/