Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Lung Neoplasms/genetics"'
Autor:
Manuel R. Teixeira, Júlio Oliveira, Paula Borralho, Maria Gabriela O. Fernandes, Teresa Almodovar, Isabel Fernandes, Daniela Macedo, Ana Ferreira, Ana Barroso, Encarnação Teixeira, José Carlos Machado
Publikováno v:
Acta Médica Portuguesa, Vol 35, Iss 9 (2022)
Next-generation sequencing (NGS) has been implemented in clinical oncology for diagnosis, prognosis, and therapeutic guidance. Among the various NGS applications in molecular oncology, we focused on the following topics: laboratory standards for targ
Externí odkaz:
https://doaj.org/article/6db7b99ec62f463f9c90b94b686aac13
Publikováno v:
Nature Medicine. 29:1563-1577
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01423::18f2a9d680e0ed9163d4be3201768751
https://doi.org/10.1038/s41591-023-02327-2
https://doi.org/10.1038/s41591-023-02327-2
Autor:
Bo Wang, Andy Law, Tim Regan, Nicholas Parkinson, Joby Cole, Clark D. Russell, David H. Dockrell, Michael U. Gutmann, J. Kenneth Baillie
Publikováno v:
Wang, B, Law, A, Regan, T, Parkinson, N, Cole, J, Russell, C D, Dockrell, D H, Gutmann, M U & Baillie, J K 2022, ' Systematic comparison of ranking aggregation methods for gene lists in experimental results ', Bioinformatics, vol. 38, no. 21, pp. 4927-4933 . https://doi.org/10.1093/bioinformatics/btac621
Motivation A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. The gene lists resulting from a group of studies answering the same, or similar, questions can be combined by rankin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73e1750452165ed9cc1fb9b8cff2957
https://doi.org/10.1093/bioinformatics/btac621
https://doi.org/10.1093/bioinformatics/btac621
Autor:
Doron Tolomeo, Debora Traversa, Santina Venuto, Karoline K. Ebbesen, Juan L. García Rodríguez, Grazia Tamma, Marianna Ranieri, Giorgia Simonetti, Martina Ghetti, Matteo Paganelli, Grazia Visci, Arcangelo Liso, Klaas Kok, Lucia Anna Muscarella, Federico Pio Fabrizio, Maria Antonia Frassanito, Aurelia Lamanuzzi, Ilaria Saltarella, Antonio Giovanni Solimando, Alessandro Fatica, Zaira Ianniello, René Massimiliano Marsano, Antonio Palazzo, Amalia Azzariti, Vito Longo, Stefania Tommasi, Domenico Galetta, Annamaria Catino, Alfredo Zito, Tommaso Mazza, Alessandro Napoli, Giovanni Martinelli, Jørgen Kjems, Lasse Sommer Kristensen, Angelo Vacca, Clelia Tiziana Storlazzi
Publikováno v:
Genes Chromosomes and Cancer. Wiley
Tolomeo, D, Traversa, D, Venuto, S, Ebbesen, K, Garcia Rodriguez, J L, Tamma, G, Ranieri, M, Simonetti, G, Ghetti, M, Paganelli, M, Visci, G, Liso, A, Kok, K, Muscarella, L A, Fabrizio, F P, Frassanito, M A, Lamanuzzi, A, Saltarella, I, Solimando, A G, Fatica, A, Ianiello, Z, Marsano, R M, Palazzo, A, Azzariti, A, Longo, V, Tommasi, S, Galetta, D, Catino, A, ZIto, A, Mazza, T, Napoli, A, Martinelli, G, Kjems, J, Kristensen, L S, Vacca, A & Storlazzi, C T 2023, ' circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer ', Genes, Chromosomes & Cancer, vol. 62, no. 7, pp. 377-391 . https://doi.org/10.1002/gcc.23121
Tolomeo, D, Traversa, D, Venuto, S, Ebbesen, K, Garcia Rodriguez, J L, Tamma, G, Ranieri, M, Simonetti, G, Ghetti, M, Paganelli, M, Visci, G, Liso, A, Kok, K, Muscarella, L A, Fabrizio, F P, Frassanito, M A, Lamanuzzi, A, Saltarella, I, Solimando, A G, Fatica, A, Ianiello, Z, Marsano, R M, Palazzo, A, Azzariti, A, Longo, V, Tommasi, S, Galetta, D, Catino, A, ZIto, A, Mazza, T, Napoli, A, Martinelli, G, Kjems, J, Kristensen, L S, Vacca, A & Storlazzi, C T 2023, ' circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer ', Genes, Chromosomes & Cancer, vol. 62, no. 7, pp. 377-391 . https://doi.org/10.1002/gcc.23121
Small Cell Lung Cancer (SCLC) is treated as a homogeneous disease, although the expression of NEUROD1, ASCL1, POU2F3, and YAP1 identifies distinct molecular subtypes. The MYC oncogene, amplified in SCLC, was recently shown to act as a lineage-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40db04445498364c91794a11b046764c
https://research.rug.nl/en/publications/fb27f467-19bc-432d-aa78-95dc980623af
https://research.rug.nl/en/publications/fb27f467-19bc-432d-aa78-95dc980623af
Autor:
Elizabeth Hedgeman, Jon P. Fryzek, Lars Pedersen, Deirdre Cronin-Fenton, Mette Nørgaard, Torben Riis Rasmussen, Naimisha Movva, Tapashi Dalvi, Stephen Hamilton-Dutoit, Hanh Hansen, Anders Mellemgaard, Norah J. Shire
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Cronin-Fenton, D, Dalvi, T, Movva, N, Pedersen, L, Hansen, H, Fryzek, J, Hedgeman, E, Mellemgaard, A, Rasmussen, T R, Shire, N, Hamilton-Dutoit, S & Nørgaard, M 2021, ' PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients : a Danish cohort study ', Scientific Reports, vol. 11, no. 1, 16892 . https://doi.org/10.1038/s41598-021-96486-2
Cronin-Fenton, D, Dalvi, T, Movva, N, Pedersen, L, Hansen, H, Fryzek, J, Hedgeman, E, Mellemgaard, A, Rasmussen, T R, Shire, N, Hamilton-Dutoit, S & Nørgaard, M 2021, ' PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients : a Danish cohort study ', Scientific Reports, vol. 11, no. 1, pp. 16892 . https://doi.org/10.1038/s41598-021-96486-2
Scientific Reports
Cronin-Fenton, D, Dalvi, T, Movva, N, Pedersen, L, Hansen, H, Fryzek, J, Hedgeman, E, Mellemgaard, A, Rasmussen, T R, Shire, N, Hamilton-Dutoit, S & Nørgaard, M 2021, ' PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients : a Danish cohort study ', Scientific Reports, vol. 11, no. 1, 16892 . https://doi.org/10.1038/s41598-021-96486-2
Cronin-Fenton, D, Dalvi, T, Movva, N, Pedersen, L, Hansen, H, Fryzek, J, Hedgeman, E, Mellemgaard, A, Rasmussen, T R, Shire, N, Hamilton-Dutoit, S & Nørgaard, M 2021, ' PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients : a Danish cohort study ', Scientific Reports, vol. 11, no. 1, pp. 16892 . https://doi.org/10.1038/s41598-021-96486-2
Scientific Reports
Programmed cell death receptor ligand-1 (PD-L1) expression, KRAS (KRASm) and EGFR (EGFRm) mutations may influence non-small cell lung cancer (NSCLC) prognosis. We aimed to evaluate PD-L1 expression, KRASm, and EGFRm and survival among stage III unres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c714e5100877d9c2cba31cc1cb53eae7
https://doaj.org/article/b4c1a9ab9ce54222a8cc1b0d41e549b9
https://doaj.org/article/b4c1a9ab9ce54222a8cc1b0d41e549b9
Autor:
Shun-Qing Liang, Haibin Deng, Ren-Wang Peng, Gregor J. Kocher, Sabina Berezowska, Qinghua Zhou, Zhang Yang, Rémy Bruggmann, Sean Hall, Yanyun Gao, Duo Xu, Thomas M. Marti, Ralph A. Schmid, Haitang Yang
Publikováno v:
Cancer research, vol. 81, no. 11, pp. 3121-3133
Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplified tumors. The dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3974a8b4da8571f690f7572bb8db80f
https://doi.org/10.1158/0008-5472.can-20-2276
https://doi.org/10.1158/0008-5472.can-20-2276
Autor:
Oluf Dimitri Røe, Jenette Creaney
Publikováno v:
Røe, O D, Creaney, J & BAP1 Study Group 2022, ' Response to "Revisiting 'BAP1ness' in Malignant Pleural Mesothelioma" ', Journal of Thoracic Oncology, vol. 17, no. 8, pp. e69-e70 . https://doi.org/10.1016/j.jtho.2022.05.013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45d68980551b5decbdd050b3ae61409
https://pubmed.ncbi.nlm.nih.gov/35931424
https://pubmed.ncbi.nlm.nih.gov/35931424
Publikováno v:
Cancer letters, vol. 484, pp. 50-64
Solid tumor growth triggers a dynamic host response, which recapitulates wound healing and defines the tumor microenvironment (TME). In addition to the action of the tumor cells themselves, the TME is maintained by a myriad of immune and stromal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d4c526f18540dbdc86599d3242ed3f
https://doi.org/10.1016/j.canlet.2020.05.005
https://doi.org/10.1016/j.canlet.2020.05.005
Publikováno v:
Cancer Genomics & Proteomics, Vol. 17, No 5 (2020) pp. 597-603
Cancer Genomics Proteomics
Cancer Genomics Proteomics
Background/Aim: Non-small cell lung cancer (NSCLC) patients with activating somatic mutations in the epidermal growth factor receptor (EGFR) have better outcomes with tyrosine kinase inhibitors (TKIs) than with chemotherapy. However, even with the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d312c1999e489861fdf5dde140077
https://doi.org/10.21873/cgp.20216
https://doi.org/10.21873/cgp.20216