Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Lunfeng Zhang"'
Autor:
Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle wit
Externí odkaz:
https://doaj.org/article/af78efbb43a14df4a0071f5cb6653928
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010630 (2023)
FLNC, encoding filamin C, is one of the most mutated genes in dilated and hypertrophic cardiomyopathy. However, the precise role of filamin C in mammalian heart remains unclear. In this study, we demonstrated Flnc global (FlncgKO) and cardiomyocyte-s
Externí odkaz:
https://doaj.org/article/c362bcd92fc24f61b0c795bb79617956
Autor:
Changming Tan, Siting Zhu, Zee Chen, Canzhao Liu, Yang E Li, Mason Zhu, Zhiyuan Zhang, Zhiwei Zhang, Lunfeng Zhang, Yusu Gu, Zhengyu Liang, Thomas G Boyer, Kunfu Ouyang, Sylvia M Evans, Xi Fang
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009785 (2021)
Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects. Mediator is a multi-subunit complex that plays a ce
Externí odkaz:
https://doaj.org/article/18fca6d6e79348038660f42598de6a01
Autor:
Canzhao Liu, Simone Spinozzi, Wei Feng, Ze’e Chen, Lunfeng Zhang, Siting Zhu, Tongbin Wu, Xi Fang, Kunfu Ouyang, Sylvia M. Evans, Ju Chen
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Nexilin (NEXN) was recently identified as a component of the junctional membrane complex required for development and maintenance of cardiac T-tubules. Loss of Nexn in mice leads to a rapidly progressive dilated cardiomyopathy (DCM) and premature dea
Externí odkaz:
https://doaj.org/article/a6fb1c606d9645daa3a6c9efdfbb0ac2
Autor:
Paola Cattaneo, Debanjan Mukherjee, Simone Spinozzi, Lunfeng Zhang, Veronica Larcher, William B. Stallcup, Hiroshi Kataoka, Ju Chen, Stefanie Dimmeler, Sylvia M. Evans, Nuno Guimarães-Camboa
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 571-582.e2 (2020)
Summary: Despite decades of studies suggesting that the in vivo adipocyte progenitor resides within the vascular niche, the exact nature of this progenitor remains controversial because distinct studies have attributed adipogenic properties to multip
Externí odkaz:
https://doaj.org/article/b01cbefa729148bdae97c8d9bac1d469
Publikováno v:
International Journal of Web Information Systems, 2020, Vol. 16, Issue 5, pp. 529-544.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/IJWIS-08-2020-0055
Autor:
Chang Chen, Cheng Luo, Hualiang Jiang, Jia Liu, Junyan Lu, Panpan Zhang, Hong Ding, Yingying Zhao, Xinhua Qiao, Lunfeng Zhang, Dan Zhao, Zhen Gao, Jiangmei Li
Suppl. Fig. 1 First-round screening of PI4KIIα inhibitors;Suppl. Fig. 2 Second-round screening of PI4KIIα inhibitors;Suppl. Fig.3. Direct interaction between PI-273 analogs and PI4KIIα;Suppl. Fig. 4. PI-273 resistance screens using CRISPR-Cas9;Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e961c7a9626a643249f5547bb1faeb9
https://doi.org/10.1158/0008-5472.22416896.v1
https://doi.org/10.1158/0008-5472.22416896.v1
Autor:
Chang Chen, Cheng Luo, Hualiang Jiang, Jia Liu, Junyan Lu, Panpan Zhang, Hong Ding, Yingying Zhao, Xinhua Qiao, Lunfeng Zhang, Dan Zhao, Zhen Gao, Jiangmei Li
While phosphatidylinositol 4-kinase (PI4KIIα) has been identified as a potential target for antitumor therapy, the clinical applications of PI4KIIα are limited by a lack of specific inhibitors. Here we report the first small-molecule inhibitor (SMI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef7403602b12e6059f5ad01bbb19c2
https://doi.org/10.1158/0008-5472.c.6509681.v1
https://doi.org/10.1158/0008-5472.c.6509681.v1
Autor:
Chang Chen, Cheng Luo, Hualiang Jiang, Jia Liu, Junyan Lu, Panpan Zhang, Hong Ding, Yingying Zhao, Xinhua Qiao, Lunfeng Zhang, Dan Zhao, Zhen Gao, Jiangmei Li
suppl. table 1chemical structures and activity of representative PI-93 analogues;suppl.table 2. activity and Tm of the PI4KIIα inhibitors;Suppl. Fig.3. Direct interaction between PI-273 analogs and PI4KIIα;Suppl. Fig. 4. PI-273 resistance screens u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e05c95d32dab66127e6160f0ba49ca4
https://doi.org/10.1158/0008-5472.22416890
https://doi.org/10.1158/0008-5472.22416890
Autor:
Chang Chen, Cheng Luo, Hualiang Jiang, Jia Liu, Junyan Lu, Panpan Zhang, Hong Ding, Yingying Zhao, Xinhua Qiao, Lunfeng Zhang, Dan Zhao, Zhen Gao, Jiangmei Li
informations for experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c57f081adc8431a97b8358bf66e63b1
https://doi.org/10.1158/0008-5472.22416893.v1
https://doi.org/10.1158/0008-5472.22416893.v1