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Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

Autor: Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Leal Rodríguez, Cristina, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, Jochen M, Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, Søren, IMI DIRECT Consortium

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::a73f47f1a96111266f2e5ecdc4c829af
https://www.repository.cam.ac.uk/handle/1810/349428

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Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.

Autor: Kjerulff B; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. berkje@rm.dk.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. berkje@rm.dk.; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark. berkje@rm.dk., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Jacobsen RL; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Gladov J; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark., Larsen MH; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Lundgaard AT; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Banasik K; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Westergaard D; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mikkelsen S; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Dinh KM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Hindhede L; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Kaspersen KA; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark., Schwinn M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Juul A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Poulsen B; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Lindegaard B; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital-North Zealand, Hillerød, Denmark., Pedersen CB; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.; National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark., Sabel CE; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.; Department of Public Health, Aarhus University, DK-8000, Aarhus, Denmark.; School of Geography, Earth and Environmental Sciences, University of Plymouth, Plymouth, PL4 8AA, UK., Bundgaard H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen HS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Recurrent Pregnancy Loss Unit, Capital Region, Copenhagen University Hospitals, Hvidovre and Rigshospitalet, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark., Møller JA; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Boldsen JK; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark., Burgdorf KS; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kessing LV; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Copenhagen, Denmark., Handgaard LJ; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Thørner LW; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Didriksen M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Nyegaard M; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ødum N; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Johansson PI; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark., Jennum P; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark., Frikke-Schmidt R; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Berger SS; Centre for Diagnostics, DTU Health Technology, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark., Brunak S; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jacobsen S; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark., Hansen TF; Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Danish Headache Center and Danish Multiple Sclerosis Center, Copenhagen University Hospital, Rigshospitalet Glostrup, Glostrup, Denmark., Lundquist TK; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen TL; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Clinical Eye Research Division, Department of Ophthalmology, Zealand University, Hospital, Roskilde, Denmark., Sigsgaard T; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.; Department of Public Health, Aarhus University, DK-8000, Aarhus, Denmark., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Hjalgrim H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.; Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Rostgaard K; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; BERTHA Big Data Centre for Environment and Health, Aarhus University, Aarhus, Denmark.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Mar 16; Vol. 4 (1), pp. 50. Date of Electronic Publication: 2024 Mar 16.