Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets

Autor: Vester, Birte, Hansen, Lykke Haastrup, Lundberg, Lars Bo, Babu, Bolle Ravindra, Sørensen, Mads D., Wengel, Jesper, Douthwaite, Stephen Roger

Publikováno v: Vester, B, Hansen, L H, Lundberg, L B, Babu, B R, Sørensen, M D, Wengel, J & Douthwaite, S R 2006, ' Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets ', BMC Molecular Biology, vol. 7, no. 19, 19 . https://doi.org/10.1186/1471-2199-7-19, https://doi.org/10.1186/1471-2199-7-19

BackgroundDNAzymes cleave at predetermined sequences within RNA. A prerequisite for cleavage is that the DNAzyme can gain access to its target, and thus the DNAzyme must be capable of unfolding higher-order structures that are present in the RNA subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::86953614c8e8e1d503a8395156561e18
https://findresearcher.sdu.dk:8443/ws/files/144185105/Locked_nucleoside_analogues_expand_the_potential_of_DNAzymes_to_cleave_structured_RNA_targets.pdf

LNAzymes: Incorporation of LNA-Type Monomers into DNAzymes Markedly Increases RNA Cleavage.

Autor: Vester, Birte, Lundberg, Lars Bo, Sørensen, Mads D., Babu, B. Ravindra, Douthwaite, Stephen, Wengel, Jesper

Publikováno v: Journal of the American Chemical Society. 11/20/2002, Vol. 124 Issue 46, p13682. 2p. 3 Diagrams, 2 Graphs.

LNA and alpha-L-LNA: towards therapeutic applications.

Autor: Wengel J; Department of Chemistry, Nucleic Acid Center, University of Southern Denmark, Odense M, Denmark. jwe@chem.sdu.dk, Vester B, Lundberg LB, Douthwaite S, Sørensen MD, Babu BR, Gait MJ, Arzumanov A, Petersen M, Nielsen JT

Publikováno v: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 May-Aug; Vol. 22 (5-8), pp. 601-4.