Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lunbin, Deng"'
Autor:
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Publikováno v:
eLife, Vol 12 (2023)
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV chan
Externí odkaz:
https://doaj.org/article/1b1793fee7d349608601029e46d0c8cd
Autor:
Christine C Jao, Marc Kschonsak, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd282fdd94d6f54f454fbf1d90a6ee32
https://doi.org/10.7554/elife.84151.sa2
https://doi.org/10.7554/elife.84151.sa2
Autor:
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis L. Rohou, Philippe Bergeron, Daniel Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Peter S. Dragovich, Matthew Volgraf, Matthew R. Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel pain target due to its striking human genetics. However, clinically available drugs (e.g. lidocaine, carbamazepine, etc.) are not selective among the nine NaV chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb81783c5e491a22f8ca88176067e13
https://doi.org/10.1101/2022.11.10.515983
https://doi.org/10.1101/2022.11.10.515983
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 254-262 (2015)
GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP). However, in transgenic Alzheimer's disease (AD) mouse models which feature gra
Externí odkaz:
https://doaj.org/article/e2d55adc4687495981e5ce9ada8619a3
Autor:
Kschonsak, Marc, Jao, Christine C., Arthur, Christopher P., Rohou, Alexis L., Bergeron, Philippe, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Lunbin Deng, Jun Chen, Tianbo Li, Dragovich, Peter S., Volgraf, Matthew, Wright, Matthew R., Payandeh, Jian, Ciferri, Claudio, Tellis, John C.
Publikováno v:
eLife; 4/18/2023, p1-18, 18p
Autor:
Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 62:4091-4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation
Autor:
Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova
Publikováno v:
Journal of Medicinal Chemistry. 62:908-927
Herein, we report the discovery and optimization of a series of orally bioavailable acyl sulfonamide NaV1.7 inhibitors that are selective for NaV1.7 over NaV1.5 and highly efficacious in in vivo models of pain and hNaV1.7 target engagement. An analys
Autor:
Steven J, McKerrall, Teresa, Nguyen, Kwong Wah, Lai, Philippe, Bergeron, Lunbin, Deng, Antonio, DiPasquale, Jae H, Chang, Jun, Chen, Tania, Chernov-Rogan, David H, Hackos, Jonathan, Maher, Daniel F, Ortwine, Jodie, Pang, Jian, Payandeh, William R, Proctor, Shannon D, Shields, Jennifer, Vogt, Pengfei, Ji, Wenfeng, Liu, Elisa, Ballini, Lilia, Schumann, Glauco, Tarozzo, Girish, Bankar, Sultan, Chowdhury, Abid, Hasan, J P, Johnson, Kuldip, Khakh, Sophia, Lin, Charles J, Cohen, Christoph M, Dehnhardt, Brian S, Safina, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 62(8)
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na
Autor:
Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Michael S, Wilson, Sultan, Chowdhury, Thilo, Focken, Jun, Li, Shannon, Decker, Michael E, Grimwood, Jean-Christophe, Andrez, Ivan, Hemeon, Tao, Sheng, Chien-An, Chen, Andy, White, David H, Hackos, Lunbin, Deng, Girish, Bankar, Kuldip, Khakh, Elaine, Chang, Rainbow, Kwan, Sophia, Lin, Karen, Nelkenbrecher, Benjamin D, Sellers, Antonio G, DiPasquale, Jae, Chang, Jodie, Pang, Luis, Sojo, Andrea, Lindgren, Matthew, Waldbrook, Zhiwei, Xie, Clint, Young, James P, Johnson, C Lee, Robinette, Charles J, Cohen, Brian S, Safina, Daniel P, Sutherlin, Daniel F, Ortwine, Christoph M, Dehnhardt
Publikováno v:
Journal of medicinal chemistry. 62(2)
Herein, we report the discovery and optimization of a series of orally bioavailable acyl sulfonamide Na
Autor:
Rebecca M. Reese, Michelle Dourado, Lunbin Deng, Jae H. Chang, Oded Foreman, David H. Hackos, Janet Tao, Shannon D. Shields
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(47)
Strong human genetic evidence points to an essential contribution of the voltage-gated sodium channel Nav1.7 to pain sensation: loss of Nav1.7 function leads to congenital insensitivity to pain, whereas gain-of-function mutations in theSCN9Agene that