Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Luna Simona Pane"'
Autor:
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J. Porritt, Sandra Wimberger, Anders Lundin, Carl Möller, Mike Firth, Euan Gordon, Bojana Lazovic, Aleksandra Sieńska, Luna Simona Pane, Matthew A. Coelho, Giovanni Ciotta, Giovanni Pellegrini, Marcella Sini, Xiufeng Xu, Suman Mitra, Mohammad Bohlooly-Y, Benjamin J. M. Taylor, Grzegorz Sienski, Marcello Maresca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in
Externí odkaz:
https://doaj.org/article/5902061ff2c8407598c33e5d4d157a46
Autor:
Alba Carreras, Luna Simona Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz M. Mayr, Rosie Perkins, Daniel Lindén, Jan Borén, Mohammad Bohlooly-Y, Marcello Maresca
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeo
Externí odkaz:
https://doaj.org/article/c78e539e95c14e998f30f49acc7e488d
Autor:
Matthew A. Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta, Jonathan D. Wrigley, Maria Emanuela Cuomo, Marcello Maresca, Benjamin J. M. Taylor
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the efficient enrichment of
Externí odkaz:
https://doaj.org/article/0ab60b8c66d0494f86e886029d99eee7
Autor:
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J. Porritt, Sandra Wimberger, Anders Lundin, Carl Möller, Mike Firth, Euan Gordon, Bojana Lazovic, Aleksandra Sieńska, Luna Simona Pane, Matthew A. Coelho, Giovanni Ciotta, Giovanni Pellegrini, Marcella Sini, Xiufeng Xu, Suman Mitra, Mohammad Bohlooly-Y, Benjamin J. M. Taylor, Grzegorz Sienski, Marcello Maresca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/751b936669984511ba04755a2e74efd0
Autor:
Luna Simona Pane, Filomena Gabriella Fulcoli, Andrea Cirino, Alessandra Altomonte, Rosa Ferrentino, Marchesa Bilio, Antonio Baldini
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome. Tbx1 can activate and repress transcripti
Externí odkaz:
https://doaj.org/article/e27f6255fce94fab87deb35d721f3b0a
Autor:
Revital Schick, Lucy N Mekies, Yuval Shemer, Binyamin Eisen, Tova Hallas, Ronen Ben Jehuda, Meital Ben-Ari, Agnes Szantai, Lubna Willi, Rita Shulman, Michael Gramlich, Luna Simona Pane, Ilaria My, Dov Freimark, Marta Murgia, Gianluca Santamaria, Mihaela Gherghiceanu, Michael Arad, Alessandra Moretti, Ofer Binah
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205719 (2018)
AIMS:Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathologica
Externí odkaz:
https://doaj.org/article/e1a99e6238e543028fefdc138f726611
Autor:
Michael Gramlich, Luna Simona Pane, Qifeng Zhou, Zhifen Chen, Marta Murgia, Sonja Schötterl, Alexander Goedel, Katja Metzger, Thomas Brade, Elvira Parrotta, Martin Schaller, Brenda Gerull, Ludwig Thierfelder, Annemieke Aartsma‐Rus, Siegfried Labeit, John J Atherton, Julie McGaughran, Richard P Harvey, Daniel Sinnecker, Matthias Mann, Karl‐Ludwig Laugwitz, Meinrad Paul Gawaz, Alessandra Moretti
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 5, Pp 562-576 (2015)
Abstract Frameshift mutations in the TTN gene encoding titin are a major cause for inherited forms of dilated cardiomyopathy (DCM), a heart disease characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure. To date,
Externí odkaz:
https://doaj.org/article/7c654a80f21048ac9a078d405a3d0a79
Autor:
Magnus Althage, Luna Simona Pane, Frank Seeliger, Mikael Bjursell, Ralph Knöll, Daniel Lindén, Katja Madeyski-Bengtson, Marta Perez-Alcazar, Roberto Nitsch, Mohammad Bohlooly-Y, Ryan Hicks, Alba Carreras, Marcello Maresca, Rosie Perkins, Jan Borén, Amir Taheri-Ghahfarokhi, Lorenz M. Mayr, Elke Ericson, Michelle J. Porritt, Pinar Akcakaya
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Biology
BMC Biology
Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, h
Autor:
Mohammad Bohlooly-Y, Nina Akrap, Benjamin J. M. Taylor, Euan Gordon, Grzegorz Sienski, Mike Firth, Giovanni Ciotta, Anders Lundin, Matthew A. Coelho, Silvia Cerboni, Aleksandra Sieńska, Marcella Sini, Marcello Maresca, Luna Simona Pane, Giovanni Pellegrini, Xiufeng Xu, Songyuan Li, Suman Mitra, Bojana Lazovic, Sandra Wimberger, Carl Möller, Michelle J. Porritt
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the efficiency of genome editing remains low, impeding the development of gene- and cell-based
Autor:
Songyuan Li, Mike Firth, Benjamin J. M. Taylor, Marcello Maresca, Maria Emanuela Cuomo, Jonathan D. Wrigley, Luna Simona Pane, Giovanni Ciotta, Matthew A. Coelho
Publikováno v:
BMC Biology
BMC Biology, Vol 16, Iss 1, Pp 1-11 (2018)
BMC Biology, Vol 16, Iss 1, Pp 1-11 (2018)
Background Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the efficient enrichment of genetical