Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Luna Prieto Garcia"'
Autor:
Luna Prieto Garcia, Anna Vildhede, Pär Nordell, Christine Ahlström, Ahmed B. Montaser, Tetsuya Terasaki, Hans Lennernäs, Erik Sjögren
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 1029-1043 (2024)
Abstract Statins are used to reduce liver cholesterol levels but also carry a dose‐related risk of skeletal muscle toxicity. Concentrations of statins in plasma are often used to assess efficacy and safety, but because statins are substrates of mem
Externí odkaz:
https://doaj.org/article/cf95a5cd79d34978ba320a6db584d147
Autor:
Luna Prieto Garcia, Anna Lundahl, Christine Ahlström, Anna Vildhede, Hans Lennernäs, Erik Sjögren
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1194-1209 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions. This is facilitated by predefined PBPK platforms with user‐friendly graphical interfa
Externí odkaz:
https://doaj.org/article/66e79a67344e401e9f1827b177eb4ec9
Autor:
Christian Löfberg, Marianne Swanson, ZhongQing Yuan, Johan Broddefalk, Annika Westin Eriksson, Susanne Winiwarter, Martin A. Hayes, Gabrielle Saarinen, Johan Meuller, Carl Whatling, Johan Ulander, Hans Emtenäs, Johan Cassel, Monica Sundqvist, Malin Lemurell, Luna Prieto Garcia, Staffan Karlsson
Publikováno v:
Journal of medicinal chemistry. 62(9)
5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials. However, previous clinical candidates have been discontinued and the link between FLAP inhi
Autor:
Kajsa P. Kanebratt, Anna Lundahl, Hans Ericsson, David Janzén, Luna Prieto Garcia, Hans Lennernäs
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(10)
Physiologically based pharmacokinetic (PBPK) modeling for itraconazole using a bottom-up approach is challenging, not only due to complex saturable pharmacokinetics (PK) and the presence of three metabolites exhibiting CYP3A4 inhibition, but also bec
Autor:
David Janzén, Anna Lundahl, Luna Prieto Garcia, Hans Ericsson, Kajsa P. Kanebratt, Hans Lennernäs
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S70-S71
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(4)
The fraction of unbound drug (fuinc) in in vitro intrinsic clearance (CLint) incubation is an important parameter in the pursuit of accurate clearance predictions and is often predicted using algorithms based on drug lipophilicity measures. However,
Publikováno v:
Addiction biology. 21(2)
Ghrelin, a gut-brain signal, is well known to regulate energy homeostasis, food intake and appetite foremost via hypothalamic ghrelin receptors (GHS-R1A). In addition, ghrelin activates the reward systems in the brain, namely the mesolimbic dopamine
Publikováno v:
Psychoneuroendocrinology. :392-402
In addition to food intake and energy balance regulation, ghrelin mediate the rewarding and motivational properties of palatable food as well as addictive drugs. The ability of ghrelin to regulate reinforcement involves the cholinergic-dopaminergic r