Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Luna C. Schmacke"'
Autor:
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C. Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J. Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive to Gq- and Gi-sensitive G protein-coupled receptors (G
Externí odkaz:
https://doaj.org/article/be62b1c248c547b084b1b6712cdf03af
Autor:
Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór, Erzsébet Pászti-Gere
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115761- (2023)
The outbreak of coronavirus disease 2019 (COVID-19) pandemic strongly stimulated the development of small molecule antivirals selectively targeting type II transmembrane serine proteases (TTSP), required for the host-cell entry of numerous viruses. A
Externí odkaz:
https://doaj.org/article/2cba99daeb6c428d8c10277c3f18aaa3
Publikováno v:
ChemMedChem. 18
The Zika virus (ZIKV) remains a potential threat to the public health due to the lack of both an approved vaccination or a specific treatment. In this work, a series of peptidic inhibitors of the ZIKV protease with boroleucine as P1 residue was synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3666a27cf2d1d5cd94e787a50d883865
https://doi.org/10.1002/cmdc.202200336
https://doi.org/10.1002/cmdc.202200336
Autor:
Simon Huber, Niklas J. Braun, Luna C. Schmacke, Jun Ping Quek, Robin Murra, Daniela Bender, Eberhard Hildt, Dahai Luo, Andreas Heine, Torsten Steinmetzer
Publikováno v:
Journal of medicinal chemistry. 65(9)
Zika virus (ZIKV) is a human pathogenic arbovirus. So far, neither a specific treatment nor a vaccination against ZIKV infections has been approved. Starting from our previously described lead structure, a series of 29 new macrocyclic inhibitors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761c3e5c8fa12f03e7dce43208c96d23
https://pubmed.ncbi.nlm.nih.gov/35475620
https://pubmed.ncbi.nlm.nih.gov/35475620