Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Autor: Wang, Z, Aguilar, EG, Luna, JI, Dunai, C, Khuat, LT, Le, CT, Mirsoian, A, Minnar, CM, Stoffel, KM, Sturgill, IR, Grossenbacher, SK, Withers, SS, Rebhun, RB, Hartigan-O’Connor, DJ, Méndez-Lagares, G, Tarantal, AF, Isseroff, RR, Griffith, TS, Schalper, KA, Merleev, A, Saha, A, Maverakis, E, Kelly, K, Aljumaily, R, Ibrahimi, S, Mukherjee, S, Machiorlatti, M, Vesely, SK, Longo, DL, Blazar, BR, Canter, RJ, Murphy, WJ, Monjazeb, AM

Publikováno v: Nature medicine, vol 25, iss 1
Hepatobiliary Surg Nutr
Wang, Z; Aguilar, EG; Luna, JI; Dunai, C; Khuat, LT; Le, CT; et al.(2018). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature Medicine. doi: 10.1038/s41591-018-0221-5. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/14v385n0

© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6c29817d4fa55c123dc8a25111d8a1f
https://escholarship.org/uc/item/14v385n0

Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing.

Autor: Marusina AI; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Merleev AA; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Luna JI; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Olney L; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Haigh NE; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Yoon D; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Guo C; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware., Ovadia EM; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware., Shimoda M; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Luxardi G; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Boddu S; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Lal NN; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Takada Y; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Lam KS; Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, Sacramento, California., Liu R; Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, Sacramento, California., Isseroff RR; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Le S; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California., Nolta JA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis, Sacramento, California., Kloxin AM; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware.; Department of Materials Science and Engineering, University of Delaware, Newark, Delaware., Maverakis E; Department of Dermatology, University of California Davis School of Medicine, Sacramento, California.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2020 Feb; Vol. 38 (2), pp. 231-245. Date of Electronic Publication: 2019 Nov 23.

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.

Autor: Wang Z; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Aguilar EG; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Luna JI; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Dunai C; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Khuat LT; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Le CT; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Mirsoian A; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Minnar CM; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Stoffel KM; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Sturgill IR; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Grossenbacher SK; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA., Withers SS; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA., Rebhun RB; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA., Hartigan-O'Connor DJ; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, USA.; California National Primate Research Center, University of California Davis, Davis, CA, USA., Méndez-Lagares G; Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, USA.; California National Primate Research Center, University of California Davis, Davis, CA, USA., Tarantal AF; California National Primate Research Center, University of California Davis, Davis, CA, USA.; Department of Pediatrics, University of California Davis School of Medicine, Davis, CA, USA.; Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA, USA., Isseroff RR; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA.; Dermatology Service, Sacramento VA Medical Center, Mather, CA, USA., Griffith TS; Department of Urology, Center for Immunology, Masonic Cancer Center, Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN, USA., Schalper KA; Department of Pathology & Translational Immuno-oncology Laboratory, Yale University School of Medicine, New Haven, CT, USA., Merleev A; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA.; Immune Monitoring Core, University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA., Saha A; Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Maverakis E; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA.; Immune Monitoring Core, University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA., Kelly K; Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis Schoolof Medicine, Sacramento, CA, USA., Aljumaily R; Department of Internal Medicine, Section of Hematology and Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Ibrahimi S; Department of Internal Medicine, Section of Hematology and Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Mukherjee S; Department of Internal Medicine, Section of Hematology and Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Machiorlatti M; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Vesely SK; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Longo DL; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA., Blazar BR; Masonic Cancer Center and Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Canter RJ; Division of Surgical Oncology, Department of Surgery, University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA., Murphy WJ; Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA. wmjmurphy@ucdavis.edu.; Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis Schoolof Medicine, Sacramento, CA, USA. wmjmurphy@ucdavis.edu., Monjazeb AM; Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Universityof California School of Medicine, Sacramento, CA, USA.

Publikováno v: Nature medicine [Nat Med] 2019 Jan; Vol. 25 (1), pp. 141-151. Date of Electronic Publication: 2018 Nov 12.

ITK inhibition for the targeted treatment of CTCL.

Autor: Bustos-Villalobos I; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Bergstrom JW; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Haigh NE; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Luna JI; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Mitra A; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Marusina AI; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Merleev AA; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Wang EA; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Sukhov A; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Sultani H; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Liu R; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, USA., Bhardwaj G; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, USA., Guo W; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, USA., Kung HJ; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, USA., Lam KS; Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA, USA., Maverakis E; Department of Dermatology, University of California, Davis, Sacramento, CA, USA. Electronic address: emaverakis@ucdavis.edu.

Publikováno v: Journal of dermatological science [J Dermatol Sci] 2017 Jul; Vol. 87 (1), pp. 88-91. Date of Electronic Publication: 2017 Apr 03.

Canine cancer immunotherapy studies: linking mouse and human.

Autor: Park JS; Department of Surgery, University of California Davis Medical Center, Sacramento, CA 95817 USA., Withers SS; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616 USA., Modiano JF; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Animal Cancer Care and Research Center, Center for Immunology, Masonic Cancer Center, and Stem Cell Institute, University of Minnesota, St. Paul, MN 55108 USA., Kent MS; The Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA., Chen M; Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817 USA., Luna JI; Laboratory of Cancer Immunology, Department of Dermatology, University of California Davis Medical Center, Sacramento, CA 95817 USA., Culp WTN; The Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA., Sparger EE; Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 USA., Rebhun RB; The Center for Companion Animal Health, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA., Monjazeb AM; Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, CA 95817 USA., Murphy WJ; Dermatology and Internal Medicine, University of California Davis Medical Center, Sacramento, CA 95817 USA.; Department of Dermatology, Department of Internal Medicine, Division of Hematology/Oncology, School of Medicine, University of California, Davis, USA., Canter RJ; Department of Surgery, Division of Surgical Oncology, University of California Davis Medical Center, Sacramento, CA 95817 USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2016 Dec 20; Vol. 4, pp. 97. Date of Electronic Publication: 2016 Dec 20 (Print Publication: 2016).