Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lummis, Sarah CR"'
Funder: AstraZeneca
5-HT3 receptors are members of the family of pentameric ligand-gated ion channels. Each subunit has an extracellular, transmembrane, and intracellular domain. Only part of the intracellular domain structure has been solved, r
5-HT3 receptors are members of the family of pentameric ligand-gated ion channels. Each subunit has an extracellular, transmembrane, and intracellular domain. Only part of the intracellular domain structure has been solved, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1770e5c7a91dfc90136544bcee3037d8
https://www.repository.cam.ac.uk/handle/1810/340319
https://www.repository.cam.ac.uk/handle/1810/340319
Publikováno v:
Biomolecules; Volume 12; Issue 9; Pages: 1251
GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1-M4). The aim of this study was to identify i
5-HT3 receptors are members of the family of pentameric ligand gated ion channels (pLGICs). Each subunit has four transmembrane α-helices (M1-M4), with M4 being most distant from the central pore. Residues in this α-helix interact with adjacent lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f18bb2e3a26d14647b65c4b2fce373
Autor:
Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah CR, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris
Funder: Instruct-ERIC
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site,
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84120ea73af4ef579e74640afd5b0931
5-HT3 receptors are members of the Cys-loop family of ligand-gated ion channels, and, like most members of this family, there are multiple subunits that can contribute to functional pentameric receptors. 5-HT3A and 5-HT3AB receptors have been extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3139f7d165c2d5fefff4b5699ab18f59
https://www.repository.cam.ac.uk/handle/1810/264676
https://www.repository.cam.ac.uk/handle/1810/264676
Autor:
Price, Kerry L, Lummis, Sarah CR
Cys-loop receptors are major sites of action for many important therapeutically active compounds, but the sites of action of those that do not act at the orthosteric binding site or at the pore are mostly poorly understood. To help understand these,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a18b87d1682886793e64252867ac228
https://www.repository.cam.ac.uk/handle/1810/278983
https://www.repository.cam.ac.uk/handle/1810/278983
Autor:
Lummis Sarah CR, O'Brien John A
Publikováno v:
BMC Biotechnology, Vol 11, Iss 1, p 66 (2011)
Abstract Background Biolistic transfection is proving an increasingly popular method of incorporating DNA or RNA into cells that are difficult to transfect using traditional methods. The technique routinely uses 'microparticles', which are ~1 μm dia
Externí odkaz:
https://doaj.org/article/0e31ab0c5d664634a70c06f99788a295
Autor:
Reeves David C, Lummis Sarah CR
Publikováno v:
BMC Neuroscience, Vol 7, Iss 1, p 27 (2006)
Abstract Background The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABAA, and glycine receptors. While antibodies specific for the 5-HT3A receptor subunit are plentiful, and have
Externí odkaz:
https://doaj.org/article/2ce5e8126a0c403ab7c6b8086a52f717
Palonosetron is a potent 5-HT3 receptor antagonist and an effective therapeutic agent against emesis. Here we identify the molecular determinants of compound recognition in the receptor binding site by obtaining a high resolution structure of palonos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3c7352a81637c6245115cd43eb4103
https://www.repository.cam.ac.uk/handle/1810/274064
https://www.repository.cam.ac.uk/handle/1810/274064
Cys-loop receptors are the site of action of many therapeutic drugs. One of these is the smoking cessation agent varenicline, which has its major therapeutic effects at nicotinic acetylcholine (nACh) receptors but also acts at 5-HT3 receptors. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9ded43a1c802d85276a8c6278b479ad9
https://lirias.kuleuven.be/handle/123456789/487111
https://lirias.kuleuven.be/handle/123456789/487111