Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Lumir, Krejci"'
Autor:
Anna C. Papageorgiou, Michaela Pospisilova, Jakub Cibulka, Raghib Ashraf, Christopher A. Waudby, Pavel Kadeřávek, Volha Maroz, Karel Kubicek, Zbynek Prokop, Lumir Krejci, Konstantinos Tripsianes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomolecular polyelectrolyte complexes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly charged IDRs are abundant in the nucleus, yet few have been functio
Externí odkaz:
https://doaj.org/article/1fa7527070bb42e5a31e97f0127ee73d
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Autor:
Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109524- (2024)
Summary: Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (E
Externí odkaz:
https://doaj.org/article/9292610b2dda480b8b8912a6757729c2
Autor:
Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen, Lumir Krejci
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA metabolic processes suc
Externí odkaz:
https://doaj.org/article/f27960dd49134ebbb90288484d64163e
Autor:
Veronika Altmannova, Mario Spirek, Lucija Orlic, Atis Jēkabsons, Tereza Clarence, Adrian Henggeler, Jarmila Mlcouskova, Raphaël A.G. Chaleil, Joao Matos, Lumir Krejci
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105439- (2022)
Summary: During meiosis, programmed DNA double-strand breaks (DSBs) are repaired by homologous recombination. DMC1, a conserved recombinase, plays a central role in this process. DMC1 promotes DNA strand exchange between homologous chromosomes, thus
Externí odkaz:
https://doaj.org/article/b1ba76f4797844b890a9b02c8b817ef3
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-5
Externí odkaz:
https://doaj.org/article/d49c4a80c40642788272abc5c212eb04
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-17 (2017)
Abstract Background Proper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell, leading to stalling or collapse of replication forks, and has been determine
Externí odkaz:
https://doaj.org/article/121410ae72b546699f2b61ab772eec5f
Autor:
Prabha Sarangi, Veronika Altmannova, Cory Holland, Zdenka Bartosova, Fanfan Hao, Dorothea Anrather, Gustav Ammerer, Sang Eun Lee, Lumir Krejci, Xiaolan Zhao
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 143-152 (2014)
Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show
Externí odkaz:
https://doaj.org/article/f56841cc41524ee68b7396b83e363d1e
Autor:
Weixing Zhao, Lucia Molnarova, Chaoyou Xue, Mário Špírek, Ondrej Beláň, Kyle Kaniecki, Katerina Krejci, Lumir Krejci, Patrick Sung, Eric C. Greene, Simon J. Boulton, Justin B. Steinfeld, Chujian Ma, Youngho Kwon
Publikováno v:
Nucleic Acids Research
RECQ5 is one of five RecQ helicases found in humans and is thought to participate in homologous DNA recombination by acting as a negative regulator of the recombinase protein RAD51. Here, we use kinetic and single molecule imaging methods to monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29609d81735dd3420c5827517c65902d
https://doi.org/10.1093/nar/gkaa1184
https://doi.org/10.1093/nar/gkaa1184
Autor:
Prabha Sarangi, Roland Steinacher, Veronika Altmannova, Qiong Fu, Tanya T Paull, Lumir Krejci, Matthew C Whitby, Xiaolan Zhao
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004899 (2015)
Protein modifications regulate both DNA repair levels and pathway choice. How each modification achieves regulatory effects and how different modifications collaborate with each other are important questions to be answered. Here, we show that sumoyla
Externí odkaz:
https://doaj.org/article/2a0d4b114b714d5795ce8234dcb3dc53
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127739 (2015)
The possibility of replacing the originally discovered and widely used DNA reprogramming transcription factors is stimulating enormous effort to identify more effective compounds that would not alter the genetic information. Here, we describe the gen
Externí odkaz:
https://doaj.org/article/710c3eab7a05477e843eea3325b8402c