Výsledky vyhledávání - "Luma G. Magalhães"

Akademický článek

A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

Autor: Béla Ózsvári, Luma G. Magalhães, Joe Latimer, Jussi Kangasmetsa, Federica Sotgia, Michael P. Lisanti

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analog, a myristic acid (14 carbon) moiety is covalently attached to

Externí odkaz: https://doaj.org/article/8c80ce471acf425ca74005bae7311c97

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Akademický článek

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Autor: Rafael A. A. Ferreira, Ivani Pauli, Thiago S. Sampaio, Mariana L. de Souza, Leonardo L. G. Ferreira, Luma G. Magalhães, Celso de O. Rezende, Rafaela S. Ferreira, Renata Krogh, Luiz C. Dias, Adriano D. Andricopulo

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas di

Externí odkaz: https://doaj.org/article/5b6ce0ac4eb343cfa71241d2fba24483

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Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach

Autor: Renata Krogh, Rocio Marisol Espinoza Chávez, Leonardo L. G. Ferreira, Celso O. R. Junior, B. W. Slafer, Luma G. Magalhães, Luiz C. Dias, Mariana L. de Souza, Glaucius Oliva, Rafaela Salgado Ferreira, Fabio C. Cruz, Adriano D. Andricopulo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f862e19fac706904f246f688be7c3e0a
https://doi.org/10.1021/acs.jcim.9b00802

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Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines

Autor: Ricardo José Nunes, Natália Marceli Stefanes, Stephanie Milis Syracuse, Adriano D. Andricopulo, Laura Otto Walter, Fernanda da Luz Efe, Amanda Virtuoso Jacques, Maria Cláudia Santos-Silva, Ana Carolina Rabello de Moraes, Daiane Mari Perondi, Carolina Teixeira Martins, Luiz Felipe de Souza, Luma G. Magalhães, Larissa Sens, Lisandra de Oliveira Silva, Aldo Sena de Oliveira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Chalcones and their derivatives have been described as promising compounds with antiproliferative activity against leukemic cells. This study aimed to investigate the cytotoxic effect of three synthetic chalcones derived from 1-naphthylacetophenone (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6f513d021b4c1f35eee22d97f449c1
https://pubmed.ncbi.nlm.nih.gov/34496319

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Recent Advances and Perspectives in Cancer Drug Design

Autor: Luma G. Magalhães, Adriano D. Andricopulo, Leonardo L. G. Ferreira

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 90, Iss 1 suppl 2, Pp 1233-1250 (2018)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC
Anais da Academia Brasileira de Ciências, Issue: ahead, Published: 14 MAY 2018
Anais da Academia Brasileira de Ciências, Volume: 90, Issue: 1 Supplement 2, Pages: 1233-1250, Published: 14 MAY 2018

Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6232dd530e379b27ae2be7d755d363
https://doi.org/10.1590/0001-3765201820170823

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Structure-based and molecular modeling studies for the discovery of cyclic imides as reversible cruzain inhibitors with potent anti-Trypanosoma cruzi activity

Autor: Celso de O. Rezende, Renata Krogh, Luma G. Magalhães, Luiz C. Dias, Adriano D. Andricopulo, Rafaela Salgado Ferreira, Leonardo L. G. Ferreira, Mariana L. de Souza, Ivani Pauli, Thiago S. Sampaio, Rafael Augusto Alves Ferreira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Chemistry, Vol 7 (2019)

Chagas disease causes approximately 10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e1cc7cec349e46525eda3f9a23019d

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Carbamoyl Imidazoles As Potent, Reversible and Competitive Cruzain Inhibitors with in vitro and in vivo Trypanocidal Activity: A Structure-Based Drug Design Approach

Autor: Adriano D. Andricopulo, Celso O. R. Junior, Brian W. Slafer, Luma G. Magalhães, Rocio Marisol Espinoza Chávez, Glaucius Oliva, Fabio C. Cruz, Luiz C. Dias, Leonardo L. G. Ferreira, Renata Krogh, Rafaela Salgado Ferreira, Mariana L. de Souza

Publikováno v: SSRN Electronic Journal.

A virtual screening conducted with nearly 4,000,000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::827a1f7d61ccc3cee45fd5c4d0f81ed2
https://doi.org/10.2139/ssrn.3387684

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Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi

Autor: Adriano D. Andricopulo, Flavio da Silva Emery, Gabriela B. Santos, Luma G. Magalhães, Mônica Tallarico Pupo, Renata Krogh

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Chagas disease continues to be a difficult disease to eradicate, largely because of the widespread populations it affects as well as the highly toxic effects of current therapies. Thus, the exploration of innovative scaffolds, ideally with distinct m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8134f82bd7bf77d25056bdf65f421d
https://doi.org/10.1016/j.bmcl.2016.01.033

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