Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lumír Krejčí"'
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Karina Zadorozhny, Vincenzo Sannino, Ondrej Beláň, Jarmila Mlčoušková, Mário Špírek, Vincenzo Costanzo, Lumír Krejčí
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 333-340 (2017)
Summary: Fanconi anemia (FA) is a genetic disorder characterized by a defect in DNA interstrand crosslink (ICL) repair, chromosomal instability, and a predisposition to cancer. Recently, two RAD51 mutations were reported to cause an FA-like phenotype
Externí odkaz:
https://doaj.org/article/97283005af86473c93c2b628f9cbc703
Publikováno v:
Biomolecules, Vol 2, Iss 3, Pp 350-375 (2012)
DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs.
Externí odkaz:
https://doaj.org/article/a03f7bd969df4ac9a7af18142fffd611
Autor:
Karel Souček, Kamil Paruch, Lumír Krejčí, Aleš Hampl, Josef Jaroš, Milan Ešner, Radek Fedr, Peter Kollár, Petra Ovesná, Miroslava Bittová, Lucia Binó, Hana Kolářová, Kateřina Vašíčková, Petr Vaňhara, Nicol Straková, Stanislav Drápela, Fedor Nikulenkov, Prashant Khirsariya, Ondřej Hylse, Tereza Suchánková, Pounami Samadder
Detail description of synthesis and supporting data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621a022e094e2d4ba0700755c1671825
https://doi.org/10.1158/1535-7163.22508934
https://doi.org/10.1158/1535-7163.22508934
Autor:
Karel Souček, Kamil Paruch, Lumír Krejčí, Aleš Hampl, Josef Jaroš, Milan Ešner, Radek Fedr, Peter Kollár, Petra Ovesná, Miroslava Bittová, Lucia Binó, Hana Kolářová, Kateřina Vašíčková, Petr Vaňhara, Nicol Straková, Stanislav Drápela, Fedor Nikulenkov, Prashant Khirsariya, Ondřej Hylse, Tereza Suchánková, Pounami Samadder
Detail description of Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2af450a9710cf2c3505b94fce584e3
https://doi.org/10.1158/1535-7163.22508937
https://doi.org/10.1158/1535-7163.22508937
Autor:
Karel Souček, Kamil Paruch, Lumír Krejčí, Aleš Hampl, Josef Jaroš, Milan Ešner, Radek Fedr, Peter Kollár, Petra Ovesná, Miroslava Bittová, Lucia Binó, Hana Kolářová, Kateřina Vašíčková, Petr Vaňhara, Nicol Straková, Stanislav Drápela, Fedor Nikulenkov, Prashant Khirsariya, Ondřej Hylse, Tereza Suchánková, Pounami Samadder
Figure S1. In vitro profiling of SCH900776 and its selected analogs. Figure S2. Analogs of MU380 with the N-trifluoromethylpyrazol pharmacophore. Figure S3. Dot plots of flow cytometric analysis using γH2AX and Annexin V staining related to Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6e17c5a7b71ad8e67d5f9f5705156b
https://doi.org/10.1158/1535-7163.22508946
https://doi.org/10.1158/1535-7163.22508946
Autor:
Karel Souček, Kamil Paruch, Lumír Krejčí, Aleš Hampl, Josef Jaroš, Milan Ešner, Radek Fedr, Peter Kollár, Petra Ovesná, Miroslava Bittová, Lucia Binó, Hana Kolářová, Kateřina Vašíčková, Petr Vaňhara, Nicol Straková, Stanislav Drápela, Fedor Nikulenkov, Prashant Khirsariya, Ondřej Hylse, Tereza Suchánková, Pounami Samadder
Supplementary Legends for Supplemetary Figure S1 - S11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b70d35fe48e8779e16a93830d0eae56
https://doi.org/10.1158/1535-7163.22508940
https://doi.org/10.1158/1535-7163.22508940
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Autor:
Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109524- (2024)
Summary: Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (E
Externí odkaz:
https://doaj.org/article/9292610b2dda480b8b8912a6757729c2
Autor:
Anna C. Papageorgiou, Michaela Pospisilova, Jakub Cibulka, Raghib Ashraf, Christopher A. Waudby, Pavel Kadeřávek, Volha Maroz, Karel Kubicek, Zbynek Prokop, Lumir Krejci, Konstantinos Tripsianes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomolecular polyelectrolyte complexes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly charged IDRs are abundant in the nucleus, yet few have been functio
Externí odkaz:
https://doaj.org/article/1fa7527070bb42e5a31e97f0127ee73d
Autor:
Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen, Lumir Krejci
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA metabolic processes suc
Externí odkaz:
https://doaj.org/article/f27960dd49134ebbb90288484d64163e