Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lulzim Shkreta"'
Autor:
Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Benoit Chabot, Scott D. Gray-Owen, Leslie J. Parent, Alan Cochrane
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-25 (2022)
Plain Language Summary Identifying cellular factors that regulate HIV-1 RNA processing provides important insights into novel strategies to control this infection. Different members of the SR kinase family have distinct roles in regulating virus expr
Externí odkaz:
https://doaj.org/article/f6c59f5364bf49b0a2fb808840fdf7ed
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Protein phosphorylation constitutes a major post-translational modification that critically regulates the half-life, intra-cellular distribution, and activity of proteins. Among the large number of kinases that compose the human kinome tree, those ta
Externí odkaz:
https://doaj.org/article/d9d3089ca40b435abf89cc7aa9fa72c8
Autor:
Subha Dahal, Ran Cheng, Peter K. Cheung, Terek Been, Ramy Malty, Melissa Geng, Sarah Manianis, Lulzim Shkreta, Shahrazad Jahanshahi, Johanne Toutant, Rose Chan, Sean Park, Mark A. Brockman, Mohan Babu, Samira Mubareka, Karen Mossman, Arinjay Banerjee, Scott Gray-Owen, Martha Brown, Walid A. Houry, Benoit Chabot, David Grierson, Alan Cochrane
Publikováno v:
Viruses, Vol 14, Iss 1, p 60 (2021)
Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 a
Externí odkaz:
https://doaj.org/article/1c76f49ace8b4a22bb54cfbd594bd88c
Autor:
Lulzim Shkreta, Benoit Chabot
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2935-2977 (2015)
The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors. While the binding of splicing proteins and ribonucleoprotein complexes to nasc
Externí odkaz:
https://doaj.org/article/9736bb2a8a004551ac8dbf200fbf5331
Autor:
Benoit Chabot, Sherif Abou Elela, Johanne Toutant, Éric R. Paquet, Ulrike Froehlich, Lulzim Shkreta
Supplementary Table S1 from Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326fd3af143179a50fc48af09d04ef20
https://doi.org/10.1158/1535-7163.22486101
https://doi.org/10.1158/1535-7163.22486101
Autor:
Benoit Chabot, Sherif Abou Elela, Johanne Toutant, Éric R. Paquet, Ulrike Froehlich, Lulzim Shkreta
Inducing an apoptotic response is the goal of most current chemotherapeutic interventions against cancer. However, little is known about the effect of chemotherapeutic agents on the alternative splicing of apoptotic genes. Here, we have tested 20 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd0323a8a74a29fa45b0f6effd80e6
https://doi.org/10.1158/1535-7163.c.6532239.v1
https://doi.org/10.1158/1535-7163.c.6532239.v1
Publikováno v:
RNA
RNA, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩
RNA, Cold Spring Harbor Laboratory Press, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩
RNA, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩
RNA, Cold Spring Harbor Laboratory Press, In press, pp.rna.078879.121. ⟨10.1261/rna.078879.121⟩
Serine/arginine splicing factor 10 (SRSF10) is a member of the family of mammalian splicing regulators known as SR proteins. Like several of its SR siblings, the SRSF10 protein is composed of an RNA binding domain (RRM) and of arginine and serine-ric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f493d6b74aff6ccdf75b35b4700bf5f7
https://europepmc.org/articles/PMC8522700/
https://europepmc.org/articles/PMC8522700/
Autor:
Estelle R. Bennett, Yousra Khalfallah, Benoit Chabot, Alexander J. Moszczynski, Michael J. Strong, Kathryn Volkening, Lulzim Shkreta, Christine Vande Velde, Aurélien Fouillen, Hermona Soreq, Laurie Destroismaisons, Antonio Nanci, Sabrina Semmler, Quentin Delmotte, Jade-Emmanuelle Deshaies, Stéphanie Stabile, Hadjara Sidibé, Uriya Bekenstein, Anaïs Aulas, Johanne Toutant
Publikováno v:
Brain. 141:1320-1333
See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral sclerosis cases and are often misl
Autor:
Brendan Bell, P. Richard Harrigan, Johanne Toutant, Marco Blanchette, David S. Grierson, Ahalya Balachandran, Benjamin A. Story, Lulzim Shkreta, Peter K. Cheung, Alan Cochrane, Emmanuelle Wilhelm, Benoit Chabot
Publikováno v:
Nucleic Acids Research
We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains in vitro. Here we show that 1C8 decreases the expression of HIV-1 and alters splicing event
Autor:
Lulzim Shkreta, Benoit Chabot
Publikováno v:
The Journal of Cell Biology
Examples of associations between human disease and defects in pre–messenger RNA splicing/alternative splicing are accumulating. Although many alterations are caused by mutations in splicing signals or regulatory sequence elements, recent studies ha