T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Autor: Bozkus CC; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA., Brown M; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Velazquez L; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Thomas M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wilson EA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Donnell T; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ruchnewitz D; Institute for Biological Physics, University of Cologne, 50937 Cologne, Germany., Geertz D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bykov Y; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kodysh J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Oguntuyo KY; The Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roudko V; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoyos D; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Srivastava KD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleiner G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Karekar N; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McClain C; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gopal R; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nie K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Del Valle D; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Delbeau-Zagelbaum D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rodriguez D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Setal J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Carroll E; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wiesendanger M; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gulko PS; The Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Charney A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Merad M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wajnberg A; The Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Greenbaum BD; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA., Chowell D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vabret N; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luksza M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhardwaj N; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Department of Medicine, The Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Parker Institute of Cancer Immunotherapy, San Francisco, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.

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Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer.

Autor: Ravi A; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hellmann MD; AstraZeneca, Oncology R&D, New York, NY, USA., Arniella MB; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Holton M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Freeman SS; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Naranbhai V; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Center for the AIDS Programme for Research in South Africa, Durban, South Africa.; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Stewart C; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Leshchiner I; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Kim J; GlaxoSmithKline, Waltham, MA, USA., Akiyama Y; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Griffin AT; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Vokes NI; Department of Thoracic and Head and Neck Oncology, MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA., Sakhi M; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Kamesan V; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Rizvi H; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Forde PM; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Anagnostou V; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Riess JW; UC Davis Comprehensive Cancer Center, Sacramento, CA, USA., Gibbons DL; Department of Thoracic and Head and Neck Oncology, MD Anderson Cancer Center, Houston, TX, USA., Pennell NA; Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA., Velcheti V; Department of Hematology and Oncology, NYU Langone Health, New York, NY, USA., Digumarthy SR; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA., Mino-Kenudson M; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Califano A; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; J.P. Sulzberger Columbia Genome Center, New York, NY, USA., Heymach JV; Department of Thoracic and Head and Neck Oncology, MD Anderson Cancer Center, Houston, TX, USA., Herbst RS; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Brahmer JR; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Schalper KA; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Velculescu VE; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Henick BS; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Rizvi N; Synthekine, Inc., Menlo Park, CA, USA., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chow A; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Greenbaum BD; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA., Luksza M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shaw AT; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA., Wolchok J; Weill Cornell Medicine, New York, NY, USA., Hacohen N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. nhacohen@broadinstitute.org.; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA. nhacohen@broadinstitute.org.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. nhacohen@broadinstitute.org., Getz G; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. gadgetz@broadinstitute.org.; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org., Gainor JF; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA, USA. jgainor@mgh.harvard.edu.; Center for Thoracic Cancers, Massachusetts General Hospital, Boston, MA, USA. jgainor@mgh.harvard.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 May; Vol. 55 (5), pp. 807-819. Date of Electronic Publication: 2023 Apr 06.

Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site.

Autor: Stadlbauer D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McMahon M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Wan H; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Dell G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria., Khalil Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luksza M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ellebedy AH; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. andrew@scripps.edu., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Dec 21; Vol. 13 (1), pp. 7864. Date of Electronic Publication: 2022 Dec 21.

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