Oncogene-like addiction to aneuploidy in human cancers.

Autor: Girish V; Yale University School of Medicine, New Haven, CT 06511, USA.; Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Lakhani AA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Thompson SL; Yale University School of Medicine, New Haven, CT 06511, USA., Scaduto CM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Brown LM; Yale University School of Medicine, New Haven, CT 06511, USA., Hagenson RA; Yale University School of Medicine, New Haven, CT 06511, USA., Sausville EL; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Mendelson BE; Yale University School of Medicine, New Haven, CT 06511, USA., Kandikuppa PK; Yale University School of Medicine, New Haven, CT 06511, USA., Lukow DA; Yale University School of Medicine, New Haven, CT 06511, USA., Yuan ML; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Stevens EC; Yale University School of Medicine, New Haven, CT 06511, USA., Lee SN; Yale University School of Medicine, New Haven, CT 06511, USA., Schukken KM; Yale University School of Medicine, New Haven, CT 06511, USA., Akalu SM; Yale University School of Medicine, New Haven, CT 06511, USA., Vasudevan A; Yale University School of Medicine, New Haven, CT 06511, USA., Zou C; Yale University School of Medicine, New Haven, CT 06511, USA., Salovska B; Yale University School of Medicine, New Haven, CT 06511, USA., Li W; Yale University School of Medicine, New Haven, CT 06511, USA., Smith JC; Yale University School of Medicine, New Haven, CT 06511, USA., Taylor AM; Columbia University School of Medicine, New York, NY 10032, USA., Martienssen RA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Liu Y; Yale University School of Medicine, New Haven, CT 06511, USA., Sun R; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Sheltzer JM; Yale University School of Medicine, New Haven, CT 06511, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Aug 25; Vol. 381 (6660), pp. eadg4521. Date of Electronic Publication: 2023 Aug 25.

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies.

Autor: Lukow DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Stony Brook University, Stony Brook, NY 11794, USA., Sausville EL; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Suri P; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Chunduri NK; European Research Institute for the Biology of Aging, 9713 AV Groningen, the Netherlands; Department of Molecular Genetics, TU Kaiserslautern, Paul-Ehrlich Str. 24, 67663 Kaiserslautern, Germany., Wieland A; Department of Molecular Genetics, TU Kaiserslautern, Paul-Ehrlich Str. 24, 67663 Kaiserslautern, Germany., Leu J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Smith JC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Google, Inc., New York, NY 10011, USA., Girish V; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Kumar AA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Georgia Institute of Technology, Atlanta, GA 30332, USA., Kendall J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Wang Z; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Storchova Z; Department of Molecular Genetics, TU Kaiserslautern, Paul-Ehrlich Str. 24, 67663 Kaiserslautern, Germany., Sheltzer JM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: sheltzer@cshl.edu.

Publikováno v: Developmental cell [Dev Cell] 2021 Sep 13; Vol. 56 (17), pp. 2427-2439.e4. Date of Electronic Publication: 2021 Aug 04.

Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy.

Autor: Hintzen DC; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Schubert M; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Soto M; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Medema RH; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. r.h.medema-2@prinsesmaximacentrum.nl.; Oncode Institute, Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands. r.h.medema-2@prinsesmaximacentrum.nl., Raaijmakers JA; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. j.raaijmakers@nki.nl.

Publikováno v: EMBO reports [EMBO Rep] 2024 Nov; Vol. 25 (11), pp. 5169-5193. Date of Electronic Publication: 2024 Sep 18.

An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors.

Autor: Gualdrini, Francesco¹ (AUTHOR) francesco.gualdrini@ieo.it, Rizzieri, Stefano¹ (AUTHOR), Polletti, Sara¹ (AUTHOR), Pileri, Francesco¹ (AUTHOR), Zhan, Yinxiu¹ (AUTHOR), Cuomo, Alessandro¹ (AUTHOR), Natoli, Gioacchino¹ (AUTHOR) gioacchino.natoli@ieo.it

Publikováno v: Molecular Systems Biology. Jun2024, Vol. 20 Issue 6, p626-650. 25p.

A Bayesian method to infer copy number clones from single-cell RNA and ATAC sequencing.

Autor: Patruno, Lucrezia^1,2 (AUTHOR), Milite, Salvatore^2,3 (AUTHOR), Bergamin, Riccardo² (AUTHOR), Calonaci, Nicola² (AUTHOR), D'Onofrio, Alberto² (AUTHOR), Anselmi, Fabio² (AUTHOR), Antoniotti, Marco^1,4 (AUTHOR), Graudenzi, Alex^1,4 (AUTHOR), Caravagna, Giulio² (AUTHOR) gcaravagna@units.it

Publikováno v: PLoS Computational Biology. 11/2/2023, Vol. 19 Issue 11, p1-19. 19p.