Výsledky vyhledávání - "Lukkana Suksanpaisan"

Akademický článek

Neoadjuvant systemic oncolytic vesicular stomatitis virus is safe and may enhance long-term survivorship in dogs with naturally occurring osteosarcoma

Publikováno v: Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100736- (2023)

Osteosarcoma is a devastating bone cancer that disproportionally afflicts children, adolescents, and young adults. Standard therapy includes surgical tumor resection combined with multiagent chemotherapy, but many patients still suffer from metastati

Externí odkaz: https://doaj.org/article/f4f7cab98bbe4ae5a0cfe31df10cc42c

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Akademický článek

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)

The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-

Externí odkaz: https://doaj.org/article/8ffcb39c8aed4257acfa76228d16a408

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Akademický článek

Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection

Autor: Lianwen Zhang, Lukkana Suksanpaisan, Huailei Jiang, Timothy R. DeGrado, Stephen J. Russell, Ming Zhao, Kah-Whye Peng

Publikováno v: Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 178-185 (2019)

Noninvasive dual-imaging methods that provide an early readout on tumor permissiveness to virus infection and tumor cell death could be valuable in optimizing development of oncolytic virotherapies. Here, we have used the sodium iodide symporter (NIS

Externí odkaz: https://doaj.org/article/06b2d49822da43eba0a11a88afc2524f

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Akademický článek

IMMUNO-COV v2.0: Development and Validation of a High-Throughput Clinical Assay for Measuring SARS-CoV-2-Neutralizing Antibody Titers

Publikováno v: mSphere, Vol 6, Iss 3 (2021)

Since its emergence at the end of 2019, SARS-CoV-2, the causative agent of COVID-19, has caused over 100 million infections and 2.4 million deaths worldwide. Recently, countries have begun administering approved COVID-19 vaccines, which elicit strong

Externí odkaz: https://doaj.org/article/fd6c7795e5dc4c6292e6a1ae0c6f3949

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Akademický článek

Preclinical Development of Oncolytic Immunovirotherapy for Treatment of HPVPOS Cancers

Autor: Lukkana Suksanpaisan, Rong Xu, Mulu Z. Tesfay, Carolyn Bomidi, Stefan Hamm, Rianna Vandergaast, Nathan Jenks, Michael B. Steele, Ayuko Ota-Setlik, Hinna Akhtar, Amara Luckay, Rebecca Nowak, Kah Whye Peng, John H. Eldridge, David K. Clarke, Stephen J. Russell, Rosa Maria Diaz

Publikováno v: Molecular Therapy: Oncolytics, Vol 10, Iss , Pp 1-13 (2018)

Immunotherapy for HPVPOS malignancies is attractive because well-defined, viral, non-self tumor antigens exist as targets. Several approaches to vaccinate therapeutically against HPV E6 and E7 antigens have been adopted, including viral platforms suc

Externí odkaz: https://doaj.org/article/3396dace4a2548be8e2c17cb86f01e32

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Akademický článek

Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy

Autor: Amber Miller, Lukkana Suksanpaisan, Shruthi Naik, Rebecca Nace, Mark Federspiel, Kah Whye Peng, Stephen J Russell

Publikováno v: Molecular Therapy: Oncolytics, Vol 1, Iss C (2014)

Systemically administered oncolytic viruses have the ability to cause tumor destruction through the expansion and coalescence of intratumoral infectious centers. Efficacy is therefore dependent upon both the density and intratumoral distribution of v

Externí odkaz: https://doaj.org/article/b056060eb1de4a149784c7300086e369

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Akademický článek

Mathematical model for radial expansion and conflation of intratumoral infectious centers predicts curative oncolytic virotherapy parameters.

Autor: Kent Bailey, Amber Kirk, Shruthi Naik, Rebecca Nace, Michael B Steele, Lukkana Suksanpaisan, Xing Li, Mark J Federspiel, Kah-Whye Peng, David Kirk, Stephen J Russell

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73759 (2013)

Simple, inductive mathematical models of oncolytic virotherapy are needed to guide protocol design and improve treatment outcomes. Analysis of plasmacytomas regressing after a single intravenous dose of oncolytic vesicular stomatitis virus in myeloma

Externí odkaz: https://doaj.org/article/8c76d8540814499081db66081136914d

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