Average outpouring velocity and flow rate of grains discharged from a tilted quasi-2D silo

Autor: Kozlowski, Ryan, Luketich, J. Carter, Oshatz, Elijah, Durian, Douglas J., Pugnaloni, Luis A.

The flow of granular materials through constricted openings is important in many natural and industrial processes. These complex flows - featuring dense, dissipative flow in the bulk but low-dissipation, low density outpouring in the vicinity of the

Externí odkaz: http://arxiv.org/abs/2210.05732

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Oncogenic signaling pathways in the Cancer Genome Atlas

Autor: Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., Chakravarty, D., Daian, F., Gao, Q., Bailey, M. H., Liang, W. -W., Foltz, S. M., Shmulevich, I., Ding, L., Heins, Z., Ochoa, A., Gross, B., Gao, J., Zhang, H., Kundra, R., Kandoth, C., Bahceci, I., Dervishi, L., Doğrusöz, Uğur, Zhou, W., Shen, H., Laird, P. W., Way, G. P., Greene, C. S., Liang, H., Xiao, Y., Wang, C., Iavarone, A., Berger, A. H., Bivona, T. G., Lazar, A. J., Hammer, G. D., Giordano, T., Kwong, L. N., McArthur, G., Huang, C., Tward, A. D., Frederick, M. J., McCormick, F., Meyerson, M., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. 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Publikováno v: Cell
Cell, vol. 173, no. 2, pp. 321-337.e10
Sanchez-Vega, Francisco; Mina, Marco; Armenia, Joshua; Chatila, Walid K; Luna, Augustin; La, Konnor C; Dimitriadoy, Sofia; Liu, David L; Kantheti, Havish S; Saghafinia, Sadegh; Chakravarty, Debyani; Daian, Foysal; Gao, Qingsong; Bailey, Matthew H; Liang, Wen-Wei; Foltz, Steven M; Shmulevich, Ilya; Ding, Li; Heins, Zachary; Ochoa, Angelica; ... (2018). Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell, 173(2), 321-337.e10. Cell Press 10.1016/j.cell.2018.03.035
Cell, 173(2), 321. Cell Press
337.e10
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell, vol 173, iss 2

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7bd5babae899051cba8e4370f28d5e
https://hdl.handle.net/11693/49844

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Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.

Autor: Chuckran CA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Cillo AR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Moskovitz J; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Overacre-Delgoffe A; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Somasundaram AS; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Shan F; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Integrative Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Magnon GC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Kunning SR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Abecassis I; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Zureikat AH; Department of Surgery, Division of Surgical Oncology, UPMC Hillman Cancer Center and UPMC Pancreatic Cancer Program, Pittsburgh, PA 15213, USA., Luketich J; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Pennathur A; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Sembrat J; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Rojas M; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Merrick DT; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Taylor SE; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Orr B; Department Obstetrics and Gynecology, Gynecologic Oncology Division, Medical University of South Carolina, Charleston, SC 29425, USA., Modugno F; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Women's Cancer Research Center, Magee-Women's Research Institute and Foundation and Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Buckanovich R; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Schoen RE; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Kim S; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Duvvuri U; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Zeh H; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, TX 75390, USA., Edwards R; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Kirkwood JM; Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Coffman L; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Ferris RL; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Vignali DAA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Dec 08; Vol. 13 (623), pp. eabf8495. Date of Electronic Publication: 2021 Dec 08.