Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Luke W. Thomas"'
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf
Autor:
Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell via
Externí odkaz:
https://doaj.org/article/bf0028ba8d264de48beb6836642740d8
Autor:
Luke W. Thomas, Margaret Ashcroft
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondria are key organelles in eukaryotic evolution that perform crucial roles as metabolic and cellular signaling hubs. Mitochondrial function and dysfunction are associated with a range of diseases, including cancer. Mitochondria support cancer
Externí odkaz:
https://doaj.org/article/ddd07f792f56401cbcd81b69bfb8ad7f
Autor:
Thomas Briston, Jenna M. Stephen, Luke W. Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E. Syafruddin, Mark Turmaine, Lucas A. Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H. Maxwell, Sakari Vanharanta, Margaret Ashcroft
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/b7f2645f5c1d4560acb8806d154ef118
Autor:
Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechan
Externí odkaz:
https://doaj.org/article/32815a8ddeae44589ff3985f781b2f2a
Autor:
Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib, Margaret Ashcroft
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria a
Externí odkaz:
https://doaj.org/article/fac9df98abc84eae9973b5eca6ebd6d6
Autor:
Alican J. Erdogan, Muna Ali, Markus Habich, Silja L. Salscheider, Laura Schu, Carmelina Petrungaro, Luke W. Thomas, Margaret Ashcroft, Lars I. Leichert, Leticia Prates Roma, Jan Riemer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 200-206 (2018)
Disulfide formation in the mitochondrial intermembrane space is an essential process catalyzed by a disulfide relay machinery. In mammalian cells, the key enzyme in this machinery is the oxidoreductase CHCHD4/Mia40. Here, we determined the in vivo CH
Externí odkaz:
https://doaj.org/article/f2e43501c2324dcab863d4394c5c4fdf
Corrigendum: CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/1e4682c6c530434da318857be2b51e17
Autor:
Thomas Briston, Jenna M. Stephen, Luke W. Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E. Syafruddin, Mark Turmaine, Lucas A. Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H. Maxwell, Sakari Vanharanta, Margaret Ashcroft
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Dysregulated mitochondrial function is associated with the pathology of a wide range of diseases including renal disease and cancer. Thus, investigating regulators of mitochondrial function is of particular interest. Previous work has shown that the
Externí odkaz:
https://doaj.org/article/e72df2ce0a76477190094194414fb2d1
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Hypoxia is a characteristic of the tumor microenvironment and is known to contribute to tumor progression and treatment resistance. Hypoxia-inducible factor (HIF) dimeric transcription factors control the cellular response to reduced oxygenation by r
Externí odkaz:
https://doaj.org/article/7b58d9a24a504b3e9db54775441d8a2e