Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Luke W. Garratt"'
Autor:
Lisa J. M. Slimmen, Vincent D. Giacalone, Craig Schofield, Hamed Horati, Badies H. A. N. Manaï, Silvia C. Estevão, Luke W. Garratt, Limin Peng, Rabindra Tirouvanziam, Hettie M. Janssens, Wendy W. J. Unger
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can promote both inflammation and resolution, and are thus critical to maintaining and restorin
Externí odkaz:
https://doaj.org/article/eae098652c744ae8b87cdc096ccd1b5e
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Persistent respiratory bacterial infections are a clinical burden in several chronic inflammatory airway diseases and are often associated with neutrophil infiltration into the lungs. Following recruitment, dysregulated neutrophil effector functions
Externí odkaz:
https://doaj.org/article/b0bd04a241684230a5fd2b5f89421254
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Differential cell counts is a challenging task when applying computer vision algorithms to pathology. Existing approaches to train cell recognition require high availability of multi-class segmentation and/or bounding box annotations and suf
Externí odkaz:
https://doaj.org/article/bc5ecf7f2ac74511b28084801ee0ef06
Autor:
Jessica Hillas, Denby J. Evans, Sherlynn Ang, Thomas Iosifidis, Luke W. Garratt, Naomi Hemy, Elizabeth Kicic-Starcevich, Shannon J. Simpson, Anthony Kicic
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/3b7de06559594504b78eadf03bc9669b
Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis
Autor:
Kak-Ming Ling, Luke W. Garratt, Erin E. Gill, Amy H. Y. Lee, Patricia Agudelo-Romero, Erika N. Sutanto, Thomas Iosifidis, Tim Rosenow, Stuart E. Turvey, Timo Lassmann, Robert E. W. Hancock, Anthony Kicic, Stephen M. Stick
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Early-life viral infections are responsible for pulmonary exacerbations that can contribute to disease progression in young children with cystic fibrosis (CF). The most common respiratory viruses detected in the CF airway are human rhinoviruses (RV),
Externí odkaz:
https://doaj.org/article/03987db3d864450e9a006f83bbab0eb4
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In response to recurrent infection in cystic fibrosis (CF), powerful innate immune signals trigger polymorphonuclear neutrophil recruitment into the airway lumen. Exaggerated neutrophil proteolytic activity results in sustained inflammation and scarr
Externí odkaz:
https://doaj.org/article/8c5a2442cbb04216a9e6d2b91013c385
Autor:
Camilla Margaroli, Hamed Horati, Luke W. Garratt, Vincent D. Giacalone, Craig Schofield, A. Susanne Dittrich, Tim Rosenow, Brian S. Dobosh, Hong S. Lim, Dario L. Frey, Mieke Veltman, George L. Silva, Milton R. Brown, Carsten Schultz, Harm A.W.M. Tiddens, Sarath Ranganathan, Joshua D. Chandler, Peng Qiu, Limin Peng, Bob J. Scholte, Marcus A. Mall, Anthony Kicic, Lokesh Guglani, Stephen M. Stick, Hettie M. Janssens, Rabindra Tirouvanziam
Publikováno v:
Journal of Cystic Fibrosis, 21(6), 967-976. Elsevier
Background: Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b2b602b00848b1117a91cdd6b14a4f
https://doi.org/10.1016/j.jcf.2022.06.001
https://doi.org/10.1016/j.jcf.2022.06.001
Autor:
Luke W. Garratt
Publikováno v:
Cells, Vol 10, Iss 9, p 2406 (2021)
Neutrophils are key cells of the innate immune system. It is now understood that this leukocyte population is diverse in both the basal composition and functional plasticity. Underlying this plasticity is a post-translational framework for rapidly ac
Externí odkaz:
https://doaj.org/article/07672a7b85cb4e66ae2c06cd06c9b840
Autor:
Joshua J. Iszatt, Alexander N. Larcombe, Hak-Kim Chan, Stephen M. Stick, Luke W. Garratt, Anthony Kicic
Publikováno v:
Viruses, Vol 13, Iss 9, p 1809 (2021)
The emergence of multi-drug resistant (MDR) bacteria is recognised today as one of the greatest challenges to public health. As traditional antimicrobials are becoming ineffective and research into new antibiotics is diminishing, a number of alternat
Externí odkaz:
https://doaj.org/article/1f61c9516fd4496c9e458b898a8d4042
Autor:
Samantha A. McLean, Leilani Cullen, Dianne J. Gardam, Craig J. Schofield, Daniel R. Laucirica, Erika N. Sutanto, Kak-Ming Ling, Stephen M. Stick, Christopher S. Peacock, Anthony Kicic, Luke W. Garratt, on behalf of AREST CF, WAERP
Publikováno v:
Pathogens, Vol 10, Iss 8, p 1020 (2021)
Aspergillus is increasingly associated with lung inflammation and mucus plugging in early cystic fibrosis (CF) disease during which conidia burden is low and strains appear to be highly diverse. It is unknown whether clinical Aspergillus strains vary
Externí odkaz:
https://doaj.org/article/beb9b38244c3493299748392230595b3