Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Luke W, Bonham"'
Autor:
Daniel W. Sirkis, Alexis P. Oddi, Caroline Jonson, Luke W. Bonham, Phuong T. Hoang, Jennifer S. Yokoyama
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Recent advances in transcriptomics research have uncovered heightened interferon (IFN) responses in neurodegenerative diseases including Alzheimer’s disease, primary tauopathy, Parkinson’s disease, TDP-43 proteinopathy, and related mouse models.
Externí odkaz:
https://doaj.org/article/341f8054296f419f8c7366289f3e0a39
Autor:
Daniel W. Sirkis, Caroline Warly Solsberg, Taylor P. Johnson, Luke W. Bonham, Virginia E. Sturm, Suzee E. Lee, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, Bruce L. Miller, Ethan G. Geier, Jennifer S. Yokoyama
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-22 (2023)
Abstract Background Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau path
Externí odkaz:
https://doaj.org/article/593d8cbdd12d4eee9bf2368860ac1c9f
Autor:
Iris J. Broce, Daniel W. Sirkis, Ryan M. Nillo, Luke W. Bonham, Suzee E. Lee, Bruce L. Miller, Patricia A. Castruita, Virginia E. Sturm, Leo S. Sugrue, Rahul S. Desikan, Jennifer S. Yokoyama
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionA hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (C9orf72) is recognized as the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and ALS-FTD. Identifyin
Externí odkaz:
https://doaj.org/article/b13a9c462df547a2b3c345568ced924f
Autor:
William G. Mantyh, J. Nicholas Cochran, Jared W. Taylor, Iris J. Broce, Ethan G. Geier, Luke W. Bonham, Ashlyn G. Anderson, Daniel W. Sirkis, Renaud La Joie, Leonardo Iaccarino, Kiran Chaudhary, Lauren Edwards, Amelia Strom, Harli Grant, Isabel E. Allen, Zachary A. Miller, Marilu L. Gorno‐Tempini, Joel H. Kramer, Bruce L. Miller, Rahul S. Desikan, Gil D. Rabinovici, Jennifer S. Yokoyama
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Early‐onset Alzheimer's disease (AD) is highly heritable, yet only 10% of cases are associated with known pathogenic mutations. For early‐onset AD patients without an identified autosomal dominant cause, we hypothesized that their early
Externí odkaz:
https://doaj.org/article/4906107fb48d48b98f50a0cb0d77e800
Autor:
Adit Friedberg, Eliana Marisa Ramos, Zhongan Yang, Luke W. Bonham, Jennifer S. Yokoyama, Peter A. Ljubenkov, Kyan Younes, Daniel H. Geschwind, Bruce L. Miller
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
CSF1R-related leukoencephalopathy is an autosomal dominant neurodegenerative disease caused by mutations in the tyrosine kinase domain of the colony stimulating factor 1 receptor (CSF1R). Several studies have found that hematogenic stem cell transpla
Externí odkaz:
https://doaj.org/article/c4c1c5e21fe44a7d8ed2f5fb6c8541bc
Autor:
Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel H. Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama
Publikováno v:
The Journal of Neuroscience. 43:333-345
Hexanucleotide repeat expansion (HRE) withinC9orf72is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfdbe4480f987d12b252f86e4c33446
https://doi.org/10.1523/jneurosci.1448-22.2022
https://doi.org/10.1523/jneurosci.1448-22.2022
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease (AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the course of n
Externí odkaz:
https://doaj.org/article/1c3f3f38af9b4c4184221a6bbf2c45e0
Publikováno v:
Molecular Psychiatry. 27:2674-2688
Early-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d38e5343b56e5bc3f3509babe93af47
https://doi.org/10.1038/s41380-022-01531-9
https://doi.org/10.1038/s41380-022-01531-9
Autor:
Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 43, iss 2
Hexanucleotide repeat expansion (HRE) within C9orf72 is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26db290663368430e8978af72589564d
https://escholarship.org/uc/item/7jr289cm
https://escholarship.org/uc/item/7jr289cm
Autor:
Jessie S. Carr, Luke W. Bonham, Alicia K. Morgans, Charles J. Ryan, Jennifer S. Yokoyama, Ethan G. Geier, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) prevalence varies by sex, suggesting that sex chromosomes, sex hormones and/or their signaling could potentially modulate AD risk and progression. Low testosterone levels are reported in men with AD. Further, variation in t
Externí odkaz:
https://doaj.org/article/10c7240fec8f43dda344e11851c523b0